List

For best search results, use the search terms first and then apply the filters
Reset

The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Cost efficient optical guidance for spinal fusion using existing radiographic equipment and augmented reality display

    SBC: OnPoint Spine, Inc.            Topic: NIBIB

    ABSTRACT The technology that will be developed in this NIH SBIR Phase I and later Phase II proposal will provide novel systems for optical guidance of spinal surgery that will not use any of the expensive components currently used for surgical navigation intra operative CT or O arm imaging or robotics Instead the technology will leverage innovative new hardware such as optical head mounted d ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Biocatalytic production of precursors to lutein and zeaxanthin to address age related macular degeneration

    SBC: EscaZyme Biochemicals, LLC            Topic: N

    Project Summary Atrophic dry age related macular degeneration AMD is the leading cause of severe loss of vision for those over age Dietary supplements containing lutein and zeaxanthin are recommended by the NEI for those at risk of late AMD There has been a corresponding growth in demand for these two xanthophylls Lutein and zeaxanthin are currently sourced from marigolds grown mostl ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Noninvasive urinary monitoring of NASH by activity based nanosensors

    SBC: Glympse Bio, Inc.            Topic: 300

    Project Summary Abstract Nonalcoholic steatohepatitis NASH is dubbed the stealth epidemic and in the U S alone percent of the million people who are estimated to have NASH will progress and develop life threatening conditions including fibrosis cirrhosis hepatocellular carcinoma and liver failure By the year NASH is projected to be the leading indication for liver transplanta ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Neuro Optical Diagnostic System for Macular Degeneration

    SBC: NEUROFIELDZ INC.            Topic: NIA

    Age related macular degeneration AMD causes progressive loss of central vision and is the leading cause of blindness in the developed world A major challenge in the development of effective treatments for AMD is the lack of sensitive practical visual function endpoints People with AMD manifest delayed dark adaptation DA recovery and DA tests are a FDA approved method for diagnosing AMD Cu ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Therapeutic game based exercise during hemodialysis to improve balance and mobility

    SBC: BioSensics LLC            Topic: NIA

    Abstract Chronic kidney disease CKD disproportionately impacts older adults Balance mobility and falls are serious problems for CKD patients due to associated peripheral neuropathy and peripheral arterial disease which also contribute to foot ulcers and other foot problems in this population Among older adults these problems are often compounded by other comorbid conditions leaving older ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. My MESSAGE Improving Wayfinding and Reducing Challenging Behaviors in Persons with Dementia Through the Use of RFID Technology

    SBC: HEARTHSTONE ALZHEIMER CARE, LTD            Topic: NIA

    In the proposed study we will develop and evaluate a product called My MESSAGE Multimedia Ecopsychosocial Support System for Alzheimer s within Geriatric Environments which will circumvent the limitations of traditional visual cues and also provide unprecedented flexibility and precision for assisting with wayfinding and reducing other challenging behaviors in PWD The target consumer for MM w ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Long lasting Biomimetic Lubricants for Diseased Tissue

    SBC: Articulate Biosciences, LLC            Topic: NIA

    ABSTRACT Many disease processes cause bodily tissues to experience high friction and concomitant pain including dry eye vaginal dryness and osteoarthritis Thus there is an unmet clinical need for new biomaterial based lubricants Of these diseases osteoarthritis OA is a complex disease that afflicts approximately million Americans and of all people years OA occurs due to prog ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Development of a robust quantitative systems pharmacology model of amyloid beta and tau pathways for clinical trial design and decision making in Alzheimer's Disease and Dementia

    SBC: Applied BioMath, LLC            Topic: NIA

    Project Summary Abstract In there were an estimated million Americans living with Alzheimerandapos s Disease AD at an annual healthcare cost of $ billion Alzheimer s Association AD is characterized by accumulation of insoluble forms of amyloid A in brain interstitium and aggregation of the microtubule protein tau in neurofibrillary tangles in neurons The development of ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. New BDNF Nanoparticles for Early Treatment of Alzheimer s Disease

    SBC: ExQor Technologies Inc            Topic: NIA

    Alzheimerandapos s Disease AD represents a major chronic health problem in the US and abroad MRI studies of AD demonstrated a decrease in the size of the hippocampus and other brain structures associated with learning and memory Toxic proteins like A and tau accumulate in these brain regions and MRS and PET imaging studies consistently showed metabolic deficits and oxidative stress in brai ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. A novel immunotolerizing therapy for autoimmune vitiligo

    SBC: RADIKAL THERAPEUTICS, INC.            Topic: NIAMS

    Radikal Therapeutics RTX is developing a pioneering therapy to restore immunotolerance and arrest progressive depigmentation in vitiligo At our partnering institution Loyola University Chicago a variant to inducible Heat Shock Protein was developed with remarkable potential for the prevention and treatment of autoimmune vitiligo Carrying only a single amino acid modification to the protei ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health

Agency Micro-sites

SBA logo
Department of Agriculture logo
Department of Commerce logo
Department of Defense logo
Department of Education logo
Department of Energy logo
Department of Health and Human Services logo
Department of Homeland Security logo
Department of Transportation logo
Environmental Protection Agency logo
National Aeronautics and Space Administration logo
National Science Foundation logo
US Flag An Official Website of the United States Government