Award Data

DESCRIPTION (provided by applicant): HIV-associated neurocognitive disorders (HAND) remain prevalent despite effective anti-retroviral treatments. Cognitive impairments in the current treatment era are often mild and not readily detectable because currentscreening measures (e.g., the HIV Dementia Scale) lack sensitivity to detect subtle impairments in cognitive function. Although more sensitive t ...

Despite significance advances in anti retroviral treatments HIV associated neurocognitive disorder HAND remains prevalent and can affect a broad range of everyday activities An effective brief cognitive screen that could be implemented in busy HIV clinics where clinicians have limited time to provide care for patients with complex medical psychiatric and cognitive conditions has the poten ...

DESCRIPTION (provided by applicant): The proposed project is related to NIMH research topic Assessment of Emotional and Psychological States. The goal is to develop a multidimensional, modular, self-report questionnaire that evaluates the course and outcome of psychiatric treatment. The Multidimensional Assessment of Symptoms and Psychosocial Functioning (MASP) is designed to assess symptom severi ...

DESCRIPTION (provided by applicant): The proposed project is related to NIMH research topic Assessment of Emotional and Psychological States. The goal is to develop a multidimensional, modular, self-report questionnaire that evaluates the course and outcome of psychiatric treatment. The Multidimensional Assessment of Symptoms and Psychosocial Functioning (MASP) is designed to assess symptom severi ...

PROJECT SUMMARYThis project s goal is to develop an innovative cost effective robotic platform for fast on demand pharmacy production of pediatric drugs as individually tailored palatable gummy dosage formsMedication adherence is notoriously low among children due to difficulty swallowing pills and rejection of bad tasting medicationsAlthough some common pediatric drugs have flavored liquid formsp ...

DESCRIPTION (provided by applicant): Of the four million cases of trauma cases each year that will require hospitalization, 200,000 will be classified as severe trauma. During the hospital stay, malnutrition is a major complication in about 50% of the patient population. The result is muscle wasting which is a major risk factor for increased morbidity and mortality. In the study proposal presente ...

Lung cancer kills 150,000 Americans and is responsible for 150 billion dollars of economic damage annually. The largest risk factor for lung cancer is smoking. When tobacco control efforts fail, early detection and treatment of lung cancer offer the best hope for survival. The National Lung Screening Trial (NLST) enrolled 53,454 subjects who reported a cigarette history of at least 30 pack years a ...

DESCRIPTION (provided by applicant): Cell Cures' technology utilizes easily isolated and well characterized adult human skeletal muscle stem cells (satellite cells or myoblasts). These striated muscle progenitor cells provide an expandable source of proliferating cells which have already been utilized in numerous clinical trials. While the injection of the proliferating myoblasts has proven clinic ...

DESCRIPTION provided by applicant A Phase II SBIR program of preclinical development is proposed for the development of an active specific immunotherapeutic called Cellariumandquot for treatment of glial cell based cancers Successful completion of this project will confirm therapeutic effect and pre clinical safety of the vaccine in preparation for first in human studies Upon demonstration of ...

DESCRIPTION (provided by applicant): Rapid detection of biological warfare agents is one of the first lines of defense against bioterrorism. The development of multiplexed sensors capable of detecting any known biological warfare agent will be essential to rapidly implement measures to protect the population and military personnel from biological attack. The goal of this proposal is to develop an ...