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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Topic 346: Targeted Radionuclide Therapy of Neuroendocrine Tumors Using 212Pb-octreotate Analogs

    SBC: RADIOMEDIX, INC.            Topic: NCI

    A peptide receptor radionuclide therapy (PRRT) using [177Lu]/[90Y]-labeled somatostatin analogs has been proven to induce objective response in 30-45% of patients with advanced/progressive neuroendocrine tumors (NETs). The complete response to beta-emitter PRRT is rare. This is due to the fact that NETs are diagnosed at late stage of disease; the NETs patients with remissions could develop resista ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Topic 379: Extensible and Scalable Platform for Data Integration from Wearable Sensors to Generate Novel Analytics for Cancer Patients

    SBC: Litmus Health, Inc.            Topic: NCI

    The longterm objective of the Litmus Health platform is to allow researchers and clinicians to use data on cancer patients from wearables/sensors and smartphones. Collecting real-time, high-quality data from patients will transform care and clinical trials. Automating data collection, storage, analysis, and interpretation of data will result in better measurement of signs and symptoms and improved ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Topic 372: Highly multiplexed selection of aptamers to hundreds of canine immunotherapy targets

    SBC: Base Pair Biotechnologies, Inc.            Topic: NCI

    The preclinical development of cancer therapeutics, including the recent trend and focus on cancer immunotherapies, is evolving from the traditional use of mouse models to the use of other animal models including canine, rat, and minipig. Each of these non-mouse models carries its own advantages and abilities to increase the clinical relevance of the model as compared to mouse models. Yet, the wid ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  4. Developing informatics tools to make immunology research data Findable, Accessible, Interoperable and Reusable

    SBC: Melax Technologies, Inc            Topic: NIAID

    Immunological research produces complex datasets ranging from molecular level to individuals and populationsSeveral data repositories aim to serve the community by housing and making the datasets available for reuseHowevertheir usage is still limited due to lack of standardizations and accessibilityOne common issue is that the datasets in these repositories are not available to generalized search ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  5. Inhaled Delivery of Clofazimine- A High Efficiency, Flow Independent, Targeted, Low Cost DPI

    SBC: Via Therapeutics, LLC            Topic: NIAID

    Multidrug resistance tuberculosisMDR TBis a global healthcare concern compounded by poor compliance associated with lengthy drug susceptible TBDS TBtreatment regimensClofazimineCFZis highly active against MDR TBbut oral use is limited by systemic toxicityhyperpigmentationGI effectsand QT prolongationInhalation of CFZ will overcome these limitations by achieving high local concentrations of drug an ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  6. Real-Time Authentication to Counter Caller ID Spoofing

    SBC: Illuma Labs Inc.            Topic: HSB0171003

    Vulnerabilities in telecommunications channels are being exploited at alarming rates by malicious attackers to commit fraud, perpetrate scams, and organize data breaches. In addition to financial losses incurred by corporations and taxpayers, attacks against government agencies such as the DHS can severely compromise national security. A common element of these attacks is the attacker's ability to ...

    SBIR Phase II 2018 Department of Homeland Security
  7. A Layered Service Provider/Customer Approach to Call Spoofing

    SBC: SECURELOGIX CORPORATION            Topic: HSB0171003

    Our proposed solution is based upon three primary concepts. First, we define the Authentication Engine, which is a cloud-based service that is passed simple information about a call, masks the complexity of using a variety of techniques to detect spoofing or authenticate the caller, and returns a score and actionable category for a very wide variety of scenarios. Second, we are making heavy use of ...

    SBIR Phase II 2018 Department of Homeland Security
  8. Low Cost Online Real Time Metal Analysis during Pharmaceutical Manufacturing

    SBC: UHV TECHNOLOGIES, INC.            Topic: NIDA

    The purpose of this SBIR Phase II contract is to develop an inexpensive and easy to use instrument that will becapable of measuring low ppm levels at least andlt ppm of a range of metals typically used in the pharmaceuticalindustry The instrument would be co located with the reaction and purification equipment where metal removalis performed and preferably amenable to continuous monitoring ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Rapid and Low cost POC Assay for Zika Virus Diagnosis

    SBC: AI BIOSCIENCES, INC.            Topic: NIAID

    PROJECT SUMMARY The aim of this proposal is to develop a rapid low cost and easy to use POC diagnostic test for Zika virus ZIKV ZIKV is an emerging mosquito borne Flavivirus that has gained global attention due to new evidence that it is linked to birth defect microcephaly Additionally health experts are also concerned about the link between the virus and Guillain Barr syndrome GBS Pres ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Novel multifunctional oligosaccharide for treating sepsis and severe sepsis

    SBC: AyuVis Research Limited            Topic: NIAID

    Project Summary Hyper inflammation induced by bacteria or bacterial products through toll like receptor TLR leads to sepsis and hence current approaches are directed towards blockade of such receptors While many such candidate antagonists have shown promise they also result in induction of inappropriate innate immune responses thus increasing risk of development of shock leading to death W ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health

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