Award Data

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DESCRIPTION (provided by applicant): Expanding use of microarray systems for global gene expression profiling is leading biological research, providing diagnostic and prognostic value to physicians and facilitating target discovery during drug and vaccine development. There is strong interest in extending this microarray capability to more RNA-limited material to the point that a single cell can b ...

DESCRIPTION (provided by applicant): We have designed a prototype lightweight, sturdy, user adjustable ergonomically designed backrest support for ultralight weight wheelchairs that will provide necessary postural support and provide a variety of positions to ease dressing, propulsion, and seated comfort. The backrest will improve user comfort, function, and posture during multiple activities of ...

DESCRIPTION (provided by applicant): Severe sepsis is a major cause of morbidity and mortality throughout the world. It is the leading cause of death in non-coronary intensive care units (ICUs) in the United States, with more than 750,000 cases occurring e very year. This means that in the United States, more than 500 patients die from severe sepsis every day, with 28% to 50% of the patients succu ...

DESCRIPTION (provided by applicant): The goal of this phase I application is to establish feasibility for a quantitative molecular diagnostics technology based on the detection of microRNA (miRNA) using readily available clinical samples. Molecular diagnostics assays offer the potential for more sensitive, more accurate, and more objective clinical judgments. For prostate cancer (PrCa), the gold s ...

DESCRIPTION (provided by applicant): The overall objective for this project is to develop a diagnostic assay for rapid detection of major mutations in patients with acute myeloid leukemia (AML), non-BCR/ABL chronic myelogenous leukemia (CML) and myeloproliferative disorders (MPDs). We propose to develop a single tube multiplex assay which uses high fidelity PCR for amplification of target mutation ...

The Domestic Nuclear Detection Office (DNDO) requires non-intrusive radiation detection equipment to identify special nuclear materials (SNM). Preferred neutron sources for the detection of SNM should have narrow pulse width, low source neutron energy, high yield and be based on non-radioactive materials. Applied Nanotech, Inc. (ANI) proposes to develop a novel field ionization technology to produ ...

The aim of this SBIR program is to develop a CNT based gas ionization source to replace radioactive 63Ni beta emitter sources used in ion detection instruments, cost effectively and without performance offsets. In Phase I, ANI worked with development partner Sionex, Inc. to establish proof of concept for basic functionality of the CNT ion source technology, demonstrating an ionic current at atmosp ...

Not avaiable.

DESCRIPTION (provided by applicant): BCR Diagnostics, Inc. (BCR) has recently developed and patented a technology platform for engineering fluorogenic functionality into living Bacillus spores. Fluorogenic spores (F-spores) produced at BCR appear to be physiologically identical to normal spores except for performing as self-reporters of initial germination events. ...