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Award Data
The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.
Download all SBIR.gov award data either with award abstracts (290MB)
or without award abstracts (65MB).
A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.
The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.
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Targeting Myosin to Treat Polycystic Kidney Disease
SBC: PLUREXA LLC Topic: 400PROJECT SUMMARY The goal of this proposal is to advance a new therapeutic approach targeting myosin for polycystic kidney disease (PKD). PKD is a major life-threatening Mendelian disorder that affects 12,000,000 individuals, representing a market opportunity of ~$1 billion. In PKD, tiny tubules in the kidneys, liver, and other organs gradually expand into fluid-filled cysts, leading to organ failu ...
STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health -
Dialysate regeneration system based on photo-electrochemical urea oxidation and reactive adsorption to enable portable hemodialysis
SBC: KULEANA TECHNOLOGY, INC. Topic: 400PROJECT SUMMARY/ ABSTRACT Currently in the US there are over 400,000 kidney patients on dialysis. The primary therapy mode is hemodialysis and is performed in a hospital or private clinic. Current dialysis therapy requires a large device that must be continuously connected to a reverse osmosis (RO) system. A single treatment will require over 150L of AAMI dialysate making portable device unattaina ...
STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health -
Novel diagnostic biomarker reference standards for newborn screening of Mucopolysaccharidoses type I and II.
SBC: GELBCHEM, LLC Topic: NICHDProject Summary The goal of this project is to design and prepare diagnostic biomarker reference standards for the endogenous glycosaminoglycan (GAG) Mucopolysaccharidosis type I (MPS-I) and type II (MPS- II) biomarkers. MPS-I and MPS-II are lysosomal storage disorders (LSDs) which are listed on the Recommended Uniform Screening Panel (RUSP) in the United States and are included in global Newborn ...
STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health -
Multispectral Sensor for Chemical Composition Analysis of Ultrafine Aerosols in Air Quality Assessment
SBC: SPECTREE INC. Topic: RProject SummaryWe propose developing and validating a novel platform technology that combines the collection and chemical analysis of ultrafine particles using an in-situ multispectral technique. The sample, collected directly onto the analysis substrate, is analyzed via excitation-emission matrix (EEM) spectroscopy. This approach will be validated against laboratory combustion-generated aerosols, ...
STTR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health -
iKinnect Mobile Technology to Reduce Teen Substance Misuse and Health Disparities
SBC: EVIDENCE-BASED PRACTICE INSTITUTE, INC. Topic: NIDAPROJECT SUMMARY/ABSTRACTAdolescent substance abuse (SA) has been called America’s #1 public health problem, affecting as many as 16% of all youth under age 18 and often resulting in serious consequences such as criminal involvement, health problems, and suicide. Given that adolescent SA is associated with high rates of comorbidity with mental health (MH) problems and increased suicide risk, inte ...
SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health -
Multiplexed biosensor for personal wildfire exposure assessment
SBC: DL ADV-TECH, LLC Topic: RSummary/Abstract: Wildfire are becoming more frequently and severe due to climate change, resulting in growing exposures of major population to high level of benzene and polycyclic aromatic hydrocarbons from biomass-burning emissions. Wildfire exposure pose a serious threat to the health and the well-being of humans. Currently, assessment of personal exposure to wildfire is dependent on taking env ...
SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health -
Deep learning methods to accelerate discoveryof drugs targeting gene regulatory proteins
SBC: TALUS BIOSCIENCE INC Topic: 400SUMMARY To evaluate how a drug candidate affects cells, researchers often study how the abundance or behavior of a specific set of proteins is changed by treatment with each compound. However, it is not currently possible to test the effect of every possible drug compound (rt500,000) on every human protein (~20,000) in hundreds of different types of cells. Even the most advanced protein analysis s ...
SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health -
High-throughput functional analysis and clinical relevance of all possible variants of a gene
SBC: HELIGENICS, INC. Topic: NHGRIModern pharmaceuticals have greatly improved the quality of life for many patients suffering a variety of illnesses. Unfortunately, among the 17 most commonly prescribed drugs, only 6 are highly effective for most patients, 5 have a modest effect, and 6 show little clinical effect. Worse still, unwanted illness and death from treatment of patients with the incorrect drug or dosage causes over 275, ...
SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health -
Validation and Improvement of ISPRI-HCP: An Innovative Platform for Immunogenicity Risk Assessment of Process-related Protein Impurities
SBC: EPIVAX, INC. Topic: NIAIDABSTRACT The identification and removal of process-related protein impurities (PRPI) from biologic products is a critical step in drug development. Despite recent improvements in the purification and processing of biologics, the presence of immunogenic PRPI continue to raise concerns about drug safety and efficacy. We propose an innovative approach for assessing immunogenicity risk of PRPI using o ...
SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health -
Activity-based regulome profiling for the discovery of covalent transcription factor inhibitors
SBC: TALUS BIOSCIENCE INC Topic: 100RESEARCH SUMMARY The human genome encodes more than 1,600 transcription factors (TFs), along with additional cofactors, chromatin regulators, and structural proteins that collectively execute the regulatory instructions encoded within the nuclear DNA. Dysfunctions of these proteins are known to drive multiple diseases such as cancer, inflammation-related, and neurological conditions. In cancer, th ...
SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health