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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Vagus Nerve Stimulation Treatment for Asthmatic Bronchoconstriction

    SBC: ROSELLINI SCIENTIFIC, LLC            Topic: NHLBI

    Project Summary The Specific Aim of this proposal is to test the feasibility of using vagus nerve stimulation VNS for treating asthma related airway constriction that is refractory to current treatments There are approximately million people with asthma in the US About percent of these asthma sufferers experience early and late phase severe asthmatic bronchoconstriction that is refract ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. A Preclinical Trial of Therapeutic Angiogenesis Plus Angioplasty and Stenting for Renal Vascular Disease

    SBC: Leflore Technologies LLC            Topic: 400

    Abstract Chronic kidney disease CKD is a progressive disorder affecting almost of the general population and this disease has shown a relentless growth over the past decades Patients with CKD have higher rates of hospitalization greater mortality shorter life expectancy and their healthcare costs are up to times more expensive than non CKD patients Thus treatments to slow halt ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Development of a microperforated nanocomposite balloon for intravascular anti restenotic drug delivery

    SBC: ROSELLINI SCIENTIFIC, LLC            Topic: NHLBI

    Hemodialysis is the most common treatment for kidney failure requiring the passing of blood out of the body through a filter and back into the body Almost of hemodialysis patients undergo arteriovenous graft procedures involving the insertion of prosthetic shunts i e synthetic tubes between artery and vein particularly in the forearm With the hemodialysis patient population estimated ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  4. SA FasL engineered human islets as a novel product for the treatment of type diabetes

    SBC: FasCure Therapeutics LLC            Topic: NIDDK

    PROJECT SUMMARY Type diabetes T D is a chronic autoimmune disorder that affects of population worldwide Exogenous insulin treatment is the standard of care for T D but often negatively affects the quality of life and is ineffective in preventing recurrent hyperglycemia episodes and chronic complications Recent studies show that human islet allografts can restore long term normoglycemia ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Facilitation of vitrification in animal model systems using a cryovial insert device

    SBC: PARATECHS CORP.            Topic: 100

    SUMMARY ParaTechs Corporation aims to provide researchers with advanced technology and methods to simplify procedures for laboratory animal models While actively supporting efforts to reduce replace and refine Rs animal use ParaTechs provides safe and effective resources for assisted reproductive techniques By implementing the Cryofork a novel tool for embryo and sperm preservation and ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Biocatalytic production of precursors to lutein and zeaxanthin to address age related macular degeneration

    SBC: EscaZyme Biochemicals, LLC            Topic: N

    Project Summary Atrophic dry age related macular degeneration AMD is the leading cause of severe loss of vision for those over age Dietary supplements containing lutein and zeaxanthin are recommended by the NEI for those at risk of late AMD There has been a corresponding growth in demand for these two xanthophylls Lutein and zeaxanthin are currently sourced from marigolds grown mostl ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Developing Testing and Validating a Wearable Alcohol Biosensor

    SBC: Clinitech, LLC            Topic: 450

    PROJECT SUMMARY This application for a Phase I SBIR award represents a collaboration between Clinitech LLC and McLean Hospital Harvard Medical School to develop a wearable biosensor for detecting alcohol in the interstitial fluid of humans who have consumed alcohol Excessive use of alcohol accounts for much of the public health burden related to alcohol use disorders including fetal ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Protection against UV radiation induced skin damage by methoxylated flavonoids

    SBC: Bluegrass Advanced Materials, LLC            Topic: NIEHS

    Project Summary In eukaryotic cells ultra violet radiation UVR induces the formation of free radicals which damage cellular lipids proteins and nucleic acids In man this damage can lead to chronic inflammation and skin neoplasias so that compounds which protect cells from UVR are of therapeutic interest Flavonoids are candidates because they protect plant cells by absorbing UVR and acting ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Novel fluorescent protein expression vector that simplifies the solubilization of membrane proteins

    SBC: PARATECHS CORP.            Topic: 300

    ABSTRACT Simple protein mutations can have serious consequences by causing diseases that affect peopleandapos s lives Protein therapeutics are developed to target and replace those protein mutations and essentially to heal the disease Distinctively membrane proteins make up over of todayandapos s drug targets However cumbersome time consuming and often ineffectual purification methods ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. A Non invasive Assay for Obstructive Sleep Apnea

    SBC: PGXL TECHNOLOGIES, LLC            Topic: NHLBI

    Project Abstract PGXL Technologies is developing novel urine based tests for detecting obstructive sleep apnea OSA in children Obstructive sleep apnea OSA is a disorder giving rise to behavioral and learning problems including misdiagnoses as attention deficit hyperactivity disorder ADHD in children The CDC estimates the prevalence of pediatric OSA in the US at around million An ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health

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