Award Data

DESCRIPTION provided by applicant Therapeutics based on nucleic acids NA promise to revolutionize treatment of multiple diseases but their widespread use is currently limited by the lack of efficient delivery methods We have recently developed a new NA delivery platform based on polymeric CXCR inhibitors PCX suitable as dual function systems for simultaneous NA delivery and inhibition of ...

DESCRIPTION provided by applicant Low level tumor associated somatic DNA mutations can have profound implications for development of metastasis prognosis choice of treatment follow up or early cancer detection Unless they are effectively detected these low level mutations can misinform patient management decisions or become missed opportunities for personalized medicine Widely used tech ...

ABSTRACT Pancreatic cancer PC is an extremely aggressive malignancy with one of the worst prognoses of all cancers with a median survival of less than one year and an overall year survival of andlt With marked resistance to chemo and radiotherapies surgery is the only curative option In patients with localized disease and no lymph node or extra pancreatic metastases complete surgical ...

DESCRIPTION provided by applicant Breast cancer is the most common type of cancer in women between the ages of and and responsible for deaths annually If treated early five year survival rates for patients in the U S are between and but drop to once metastatic breast cancer has developed Thus there is a great need to develop more effective treatment strategies fo ...

DESCRIPTION provided by applicant Freezing whole zebrafish embryos in order to later recover live fish is not currently possible Researchers seeking to preserve zebrafish genetic lines are presently limited to the options of storing frozen sperm in sperm banks or maintaining the fish alive These limitations increase costs and hinder the efficient dissemination of superior wild type and mutan ...

In the Phase-I project Avomeen LLC will advance the manufacturing technology that has already developed thermally stable separators in-house. In Phase I project, Avomeen will develop thermally stable separator and related low cost manufacturing process to achieve high energy/power density lithium ion batteries with enhanced safety. Currently micro-porous material and glass material are using as a ...

Nevada Composites has developed Green-Aero(sm) toolinglightweight ceramic tooling that is stable under high pressure and long-duration cure cycles and can be washed out with water after cures to 370C (700F). Tools, whether single-sided or washout, have a composite-compatible CTE, provide tight tolerances, are reproducible, are stable to storage under ambient conditions, and are of affordable cost. ...

Geometrically constrained underwater environments abrogate the simplifying acoustic modeling assumption that energy can be modeled in a two-dimensional vertical plane. In these environments, current tools to perform navigation and passive and/or active sonar mission planning are inadequate. Furthermore, channel complexity makes it difficult to model acoustic communications. HRC proposes to upgrade ...

The goal of this program is to develop an autonomous, hover-capable, flying robot with an onboard chemical sensor chip for chemical surveillance and environmental monitoring. The key capabilities of this integrated system will be, in order of priority: 1. Real-time chemical sensing and data transfer to a base station. The final platform will detect and identify airborne chemicals using the Mole ...

Ice accretion is a significant problem for naval ship superstructures, decks, equipment and vehicles on board naval ships. In our work we show that by tailoring the crosslink density of different elastomeric coatings, and by allowing for interfacial slippage, it is possible to systematically design coatings with extremely low ice-adhesion (ice < 1 kPa). The use of interfacial slippage as opposed t ...