Award Data

The broader impact/commercial potential of this Small Business Innovation Technology Transfer Research Phase I project is to facilitate the manufacturing and commercialization of natural and semi-synthetic products namely core lupane triterpenoids (betulin, betulinic acid, lupeol, betulinic aldehyde) as precursors for drug development and other industrial applications. Research shows that these tr ...

The broader impact/commercial potential of this Small Business Technology Transfer (STTR) Phase I project promotes a promising new approach to improve employee wellness with the potential for wider application beyond the workplace. This improved approach combines both innovative clinical diagnostics with computer assisted learning to guide recommendations. It offers the potential to curb epidemic ...

DESCRIPTION provided by applicant Therapeutics based on nucleic acids NA promise to revolutionize treatment of multiple diseases but their widespread use is currently limited by the lack of efficient delivery methods We have recently developed a new NA delivery platform based on polymeric CXCR inhibitors PCX suitable as dual function systems for simultaneous NA delivery and inhibition of ...

DESCRIPTION provided by applicant Insomnia of sufficient clinical severity to meet diagnostic criteria is present in approximately of older adults nearly million individuals n the US alone If left untreated it can lead to increased rates of depression cognitive impairment and cardiovascular disease Treatment relies on pharmacotherapy such as sedative hypnotic therapy which is ass ...

DESCRIPTION provided by applicant Low level tumor associated somatic DNA mutations can have profound implications for development of metastasis prognosis choice of treatment follow up or early cancer detection Unless they are effectively detected these low level mutations can misinform patient management decisions or become missed opportunities for personalized medicine Widely used tech ...

DESCRIPTION provided by applicant Koronis Biomedical Technologies KBT proposes to develop a novel omnidirectional low power miniaturized hearing aid telecoil replacement module TCRM based on tunneling magnetoresistance TMR technology It has been reported that million Americans have hearing loss Hearing loss affects in Americans and in households Modern telecoils assist ...

The broader impact/commercial potential of this Small Business Technology Transfer (STTR) Phase I project is to improve people's lives by creating the first wrist-based device that can reliably assess sleep quality. A large pool of undiagnosed patients and the growing population of the elderly point to a massive end-user market for sleep disorder diagnostics devices. The market is steadily increas ...

The broader impact/commercial potential of this Small Business Technology Transfer (STTR) project will be to develop an intracellular delivery technology for positively charged peptides for use in cell experiments in basic laboratory science and for delivery of peptide therapeutics for treatment of human disease. Peptides hold many advantages over the small molecule drugs that dominate the current ...

The broader impact/commercial potential of this project is to establish a precedence for remote, real time assessment of the safety and serviceability of infrastructural assets through the development of a self-powered structural health monitoring system. This piezoelectric fatigue fuse (PFF) will enable the establishment of quantifiable metrics to discern the current state of life as well as proj ...

ABSTRACT Perinatal hypoxic ischemic encephalopathy HIE affects to infants per every born Mortality from HIE can be up to and approximately of survivors suffer significant long term disability including cerebral palsy epilepsy and developmental disorders Damage during the acute phase of HIE is caused by a deficit in oxygen and glucose in the brain However increasing evide ...