Award Data

Abstract Non viral gene delivery is used in most biomedical laboratories for basic research and for many commercial and medical applications These include basic investigations into gene function modification of cells for the production of recombinant proteins and generation of genetically modified human cells for cancer therapy e g chimeric antigen receptor transgenic T cells However the d ...

There is an urgent need for more effective mechanisms that leverage current technologies and best practices to both identify capacity and refer patients to drug treatment facilitiesThe applicant organizationOpenBeds Incis partnering with the non profit MESH Coalitionthree of the largest health care systems offering drug treatment in Indiana and the Indiana Division of Mental Health and AddictionDM ...

Abstract The identification and quantification of specific proteins in complex samples are critical processes in discoveringunderstandingand ultimately addressingthe underlying nature of human health and diseaseThe western blot is a fundamental method used for these processes due to the sensitivity and specificity enabled by combining protein sizing with immuno detectionDespite being widelyusedthe ...

Project Summary Abstract Advanced Medical ElectronicsAMEproposes the development of a novel portable wireless hearing aid accessory that utilizes head pose and eye tracking of the hearing aid user to steer a microphone array in the direction of interestA common problem for hearing aid users is the difficulty of participating in conversations in a noisy environment such as at a workplace or restaur ...

Validation of a Novel Therapeutic Approach for Cryptococcal Meningitis PILadShivanand and McCabeAaron Project Summary When Cryptococcus is manifested as cryptococcal meningitisCMit creates a large burden of mortality and morbidity to the patient and is very difficult for the clinician to treatThere are now an estimatedUS cases andcases of CM worldwide annuallywith estimated mortality ofper yearCM ...

Abstract Chronic kidney disease CKD is a progressive disorder affecting almost of the general population and this disease has shown a relentless growth over the past decades Patients with CKD have higher rates of hospitalization greater mortality shorter life expectancy and their healthcare costs are up to times more expensive than non CKD patients Thus treatments to slow halt ...

ABSTRACT Poor sleep and memory problems are common in older adults and have considerable consequences including decreased productivitydeclines in cognitive abilitiesincreased rate of accidents and traffic fatalitiesand increased health care costsThese sleep and memory problems often occur in midlife and in older adultswhen aging is associated with insomniafragmentation of sleepand impairment of at ...

Abstract In this Phase I SBIR Koronis Biomedical Technologies proposes to develop and evaluate a fully implantable wireless device that monitors left ventricular pressure and volume P V in rodent studies Transgenic models of heart disease have been created through hypothesis driven research on rodents that seeks to both identify mechanistic pathways in academic research and support the develop ...

PROJECT SUMMARY ABSTRACTThis SBIR grant will drive a promising form of T cell therapycalled ATTACKtoward mainstream societyATTACK s promise as a cancer therapy is supported by clinical data that suggest it has the capacity to effectively treat solid and liquid tumorsexpose cancer cells not recognized by ATTACK to the patient s own immune system for destructioncircumvent the need for patient immuno ...

In this fast track SBIR projectKoronis Biomedical TechnologiesKBTwill develop a low cost neuro cognitive assessment tool for infants and pre school childrenNon invasive neuro cognitive assessments continue to be a very importance tool for monitoring infants and children to track normal developing milestonesuncovering cognitive deficits and evaluate treatment effectivenessLow costand easy to use to ...