Award Data

DESCRIPTION provided by applicant Alzheimerandapos s disease AD occurs in one out of eight Americans of age and affects of the elderly over Current FDA approved drugs provide short term symptomatic relief of AD There is a pressing need to discover new disease modifying medications AD is multifactorial in origin and progression A drug attenuating several underlying factors is a p ...

ABSTRACT In the US and other developed countries increased life expectancy has led to increases in aging related bladder dysfunction and associated lower urinary tract symptoms Aging and diabetes as well as many neurological conditions can result in underactive bladder UAB which can cause inefficient voiding discomfort and psychological distress as well as serious complications such as u ...

Glaucoma is a diverse group of chronic diseases that causes irreversible damage to the optic nerve and is a leading cause of blindness affecting million people worldwide It is estimated that in people who receive proper treatment for glaucoma still experience loss of vision The only proven method of treating glaucoma is to reduce the pressure in the eye Intraocular Pressure IOP Advanced glaucoma m ...

Abstract Neurological conditions such as multiple sclerosis Parkinson s disease dementia spina bifida diabetes stroke and spinal cord injury SCI can result in loss of voluntary voiding of urine and require intermittent bladder catheterization for voiding Catheter use is associated with increased incidence of health problems predominately repeated urinary tract infections sepsis ureth ...

Miya Model Simulator Phase II Abstract OB GYN Residents must develop numerous skills including pelvic exams child birth open surgery laparoscopic surgery and vaginal surgery Studies demonstrate that OB GYN Residents lack training in vaginal surgical techniques including Vaginal Hysterectomy VH Vaginal Hysterectomy is the desired technique recommended by The American College of Obstetric ...

Project Abstract The rates of HIV AIDS other STIs unplanned pregnancies and dating violence among adolescents indicate the need for evidence based medically accurate comprehensive sexual health education However both teachers and parents face challenges in effectively teaching about sexual health and relationships leading to students receiving incomplete or inaccurate information Young peo ...

SUMMARY ABSTRACT Preeclampsia is a complication of pregnancy characterized by elevated blood pressure proteinuria and endothelial dysfunction involving multiple organ systems Worldwide preeclampsia is the largest cause of fetal and maternal morbidity and mortality and accounts for nearly of maternal deaths in the United States alone each year Currently there is no approved diagnostic te ...

The goal of this Phase II effort is bring to market a unique antimicrobial catheter to reduce the instances of the most prevalent healthcare associated infection Catheter Associated Urinary Tract Infection CAUTI This research and development effort will be to develop a urinary catheter with inherent long lasting antiseptic properties to protect the patient and prevent infection We have begun ...

PROJECT SUMMARY Nucleosomes are the basic building blocks of chromatin and composed of bp DNA wrapped around a core histone octamer Chromatin function is controlled by the dynamic addition removal of histone post translational modifications PTMs Significantly alterations in specific PTMs are associated with changes in gene expression driving the emergence progression of many cancer ...

Abstract Liver fibrosis a hallmark of many liver diseases affects millions of people in America every year and annually kills tens of thousands of these patients Despite very active research efforts there still have been no specific antifibrotic drugs approved by the FDA The liver disease and drug development communities do not currently have well validated low cost easy to use noninvasiv ...