Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. Development of a Non adjuvanted VLP Vaccine against Stealth H N Influenza

    SBC: EPIVAX, INC.            Topic: NIAID

    DESCRIPTION provided by applicant The avian origin H N influenza virus that emerged in humans in China in presents a unique challenge to vaccine development because it is poorly immunogenic Neutralizing antibodies are not detected in acute phase infection Anti H antibody responses are significantly delayed and exhibit low avidity in comparison with antibodies generated following seas ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  2. Enhancing protective antibody responses for a DNA MVA HIV vaccine

    SBC: GEOVAX, INC.            Topic: NIAID

    DESCRIPTION provided by applicant The proposed work addresses a pivotal study for decisions on the form of the GeoVax Clade B HIV vaccine GOVX B to be taken into efficacy trials GOVX B is a DNA MVA vaccine that expresses virus like particles VLPs displaying trimeric membrane bound Env It has been under development for more than years during which time it has demonstrated unique pr ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  3. I Live Inspired Individually Tailored and Integrated Social Support Network for Tobacco Cessation

    SBC: Live Inspired, LLC            Topic: NIDA

    DESCRIPTION provided by applicant Smoking kills Americans annually exacerbates myriad diseases and costs billions in healthcare and productivity losses Numerous barriers exist to accessing traditional treatment e g costs traveling to and scheduling appointments other logistics Text messaging is an extremely popular communication method Over of all Americans use text m ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  4. In Situ Autovaccination against Solid Cancers with Intratumoral Hiltonol Poly ICLC A phase II Adaptive Multicenter Clinical Study

    SBC: Oncovir            Topic: 102

    DESCRIPTION provided by applicant Hiltonol poly ICLC is a stabilized dsRNA therapeutic viral mimic or andapos danger signalandapos that activates multiple elements of innate and adaptive immunity It is a standalone immunomodulator but when properly combined with antigen it generates a comprehensive Th weighted immune response best suited for antiviral and antitumor action This project ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  5. Microhook nerve tape A nerve repair coaptation aid

    SBC: Axion Biosystems, Inc.            Topic: 105

    DESCRIPTION provided by applicant This proposed project will develop and validate a microhook based nerve tape device for quick and effective repair of nerve injuries The microhook wrap consists of an array of microscale hooks distributed across a fine flexible meshwork and embedded in a biocompatible backing material This nerve tape will be used during nerve repair surgeries in place of mi ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  6. Multi Source E Beam kV X Ray Tube for Image Guided Radiotheraphy

    SBC: Telesecurity Sciences, Inc.            Topic: 102

    DESCRIPTION provided by applicant This project will develop a commercial product that will enable for the first time realtime tumor tracking during radiotherapy at an attractive price point and with minimal interference with standard clinical practice The key novel technology is an optimized multi source X ray tube with focal spots that is placed below the multi leaf collimator MLC of a r ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  7. Mutation Enriched Targeted Re Sequencing

    SBC: TRANSGENOMIC, INC.            Topic: 103

    DESCRIPTION provided by applicant Low level tumor associated somatic DNA mutations can have profound implications for development of metastasis prognosis choice of treatment follow up or early cancer detection Unless they are effectively detected these low level mutations can misinform patient management decisions or become missed opportunities for personalized medicine Widely used tech ...

    STTR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  8. Myocardial blood flow quantitation with the novel PET F Fluripidaz imaging tracer

    SBC: SYNTERMED INCORPORATED            Topic: NHLBI

    DESCRIPTION provided by applicant Myocardial blood flow quantitation with the novel F Flurpiridaz PET imaging tracer PROECT SUMMARY Coronary artery disease CAD is the single largest cause of death in the United States Prevention early diagnosis and treatment of CAD are essential to reduce the mortality Noninvasive assessments of regional myocardial blood flow at rest and during stress ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  9. Nanotechnology-Based Environmental Smart Sensors for Personal Health Exposure Monitoring

    SBC: Wi-Sense LLC            Topic: NIEHS

    DESCRIPTION provided by applicant A broad goal of the proposed research is to develop personal exposure monitors comprising wearable wireless sensor arrays to detect harmful air pollutants within the breathing zone and improve the assessment of causative exposure dose response relationships in epidemiological studies Heterogeneous orthogonal detectors comprising functionalized carbon nanotub ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  10. Novel Therapeutic Approach to Hypercholesterolemia Using Anti PCSK Selected Immune Repertoires

    SBC: ABEOME CORPORATION            Topic: NHLBI

    DESCRIPTION provided by applicant We have developed and completed a proof of principle on a new transgenic mouse model for comprehensive characterization of the antibody repertoire made in response to PCSK injection and have identified a set of high affinity neutralizing antibodies which will be tested in animals for efficacy and potency PUBLIC HEALTH RELEVANCE Therapeutic and diagnostic app ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
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