Award Data

DESCRIPTION provided by applicant A Phase II SBIR program of preclinical development is proposed for the development of an active specific immunotherapeutic called Cellariumandquot for treatment of glial cell based cancers Successful completion of this project will confirm therapeutic effect and pre clinical safety of the vaccine in preparation for first in human studies Upon demonstration of ...

DESCRIPTION provided by applicant Therapeutics based on nucleic acids NA promise to revolutionize treatment of multiple diseases but their widespread use is currently limited by the lack of efficient delivery methods We have recently developed a new NA delivery platform based on polymeric CXCR inhibitors PCX suitable as dual function systems for simultaneous NA delivery and inhibition of ...

DESCRIPTION provided by applicant Low level tumor associated somatic DNA mutations can have profound implications for development of metastasis prognosis choice of treatment follow up or early cancer detection Unless they are effectively detected these low level mutations can misinform patient management decisions or become missed opportunities for personalized medicine Widely used tech ...

DESCRIPTION provided by applicant A number of academic groups and life sciences companies are developing and testing approaches to delay aging the most significant risk factor for the vast majority of serious human diseases Critical for these efforts is the development and validation of minimally invasive cost effective biomarkers of aging DiamiR a molecular diagnostics company has deve ...

DESCRIPTION provided by applicant Urinary incontinence UI and overactive bladder OAB are highly prevalent in women and their prevalence is increased with the age In a representative United States survey UI was reported to affect from to of women The OAB prevalence estimates vary considerably among studies ranging from to These conditions are socially embarrassing causin ...

DESCRIPTION provided by applicant The avian origin H N influenza virus that emerged in humans in China in presents a unique challenge to vaccine development because it is poorly immunogenic Neutralizing antibodies are not detected in acute phase infection Anti H antibody responses are significantly delayed and exhibit low avidity in comparison with antibodies generated following seas ...

DESCRIPTION provided by applicant The emerging light based imaging technique of acoustic resolution photoacoustic endomicroscopy AR PAEM enables visualization of subsurface tissues with microscopic resolution at depths of many millimeters AR PAEM images provide crucial information regarding microvasculature morphology and tissue physiology blood oxygenation For cancers originating in ...

DESCRIPTION provided by applicant Periodontitis the inflammation of the periodontium affects of the U S population Untreated periodontitis leads to progressive loss of the periodontal ligament cementum and alveolar bone ultimately resulting in tooth loss Bone grafting procedures are performed for patients with severe bone loss Autologous bone is harvested from retro molar area ...

DESCRIPTION provided by applicant During laparoscopic surgery video camera becomes a surgeonandapos s eyes since the surgeon uses an image from the video camera positioned inside the patientandapos s body to perform the procedure The greatest limitation to these minimally invasive approaches is the impairment or complete lack of tactile sensation normally used to assist in surgical dissection ...

DESCRIPTION provided by applicant The Specific Aim of this SBIR Phase I proposal is to test the feasibility of using a technology platform to scale a newly validated method of telephonic delivery of the Diabetes Prevention Program DPP for African American and Hispanic patients who do not use the internet Pew About of the million people with pre diabetes will acquire dia ...