Award Data

The broader impact/commercial potential of this Small Business Technology Transfer (STTR) Phase I project is to enable rapid blood clotting in order to treat bleeding after a traumatic injury The majority of deaths that occur within the first 24 hours following a traumatic injury are the result of hemorrhage. The scientific merits of the project stem from the biochemical advantages of using the ph ...

DESCRIPTION provided by applicant Trichomonas vaginalis is the causative agent of the most common non viral sexually transmitted infection with million new cases reported annually in the world and million cases in the U S In addition to infections of the urogenital tract trichomoniasis increases the risk of adverse pregnancy outcomes and HIV transmission and increases the incidence ...

DESCRIPTION provided by applicant Our laboratory discovered and is developing partial p MHC class II constructs pMHC as a possible immunotherapy for multiple sclerosis MS pMHC containing the extracellular domains of the MS risk factor HLA DR linked covalently to the encephalitogenic peptide of myelin oligodendrocyte glycoprotein pDR MOG can reverse CNS inflammation and ...

The broader impact/commercial potential of this Small Business Technology Transfer (STTR) Phase I project is to improve people's lives by creating the first wrist-based device that can reliably assess sleep quality. A large pool of undiagnosed patients and the growing population of the elderly point to a massive end-user market for sleep disorder diagnostics devices. The market is steadily increas ...

The broader impact/commercial potential of this project is to establish a precedence for remote, real time assessment of the safety and serviceability of infrastructural assets through the development of a self-powered structural health monitoring system. This piezoelectric fatigue fuse (PFF) will enable the establishment of quantifiable metrics to discern the current state of life as well as proj ...

The goal of this Phase I STTR grant proposal is to stabilize live attenuated influenza vaccine LAIV using a temporary silica coating that is removed in vivo In so doing we will establish a broader technology to eliminate the cold chain required for transport of heat and cold labile vaccines Many vaccines are unstable under ambient environmental conditions Currently vaccines are either stabil ...

ABSTRACT Detecting change in neuropsychological functioning over time is critical for proper diagnosis and management of many neurological psychiatric and psychological conditions It is well documented that most commonly used cognitive assessments produce significant retest effects such as practice and regression to the mean effects Retest effects can cause substantial changes in test score ...

DESCRIPTION provided by applicant Peptide conjugated phosphorodiamidate morpholino oligomers PPMO are single stranded nucleic acid analogs able to modulate gene expression through steric blocking of complementary RNA PPMO are composed of two components an antisense morpholino oligomer cargo covalently conjugated to a cell penetrating delivery peptide PPMO are completely nuclease resistant ...

Abstract Stroke is a leading cause of morbidity and mortality in the United States However less than of patients are eligible for the current approved interventions of tissue plasminogen activator or thrombectomy We seek to develop new therapeutics to reduce the extent of damage and functional impairment resulting from ischemic injury to the brain an area of significant unmet medical need ...