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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Biocatalytic production of precursors to lutein and zeaxanthin to address age related macular degeneration

    SBC: EscaZyme Biochemicals, LLC            Topic: N

    Project Summary Atrophic dry age related macular degeneration AMD is the leading cause of severe loss of vision for those over age Dietary supplements containing lutein and zeaxanthin are recommended by the NEI for those at risk of late AMD There has been a corresponding growth in demand for these two xanthophylls Lutein and zeaxanthin are currently sourced from marigolds grown mostl ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Immunomodulatory Therapy for Diabetic Nephropathy

    SBC: APT THERAPEUTICS, INC.            Topic: 400

    Diabetic nephropathy DN is one of the most common microvascular complications of diabetes and the leading cause of end stage renal disease in Western and Asian countries The current medical management of diabetes to prevent its complications include tight glycemic control and strict management of blood pressure these established treatments delay the onset and the progression of DN however th ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Developing a Nutraceutical Product against Noise Induce Hearing Loss

    SBC: GATEWAY BIOTECHNOLOGY, INC.            Topic: NIDCD

    PROJECT SUMMARY The most common occupational and environmental hazard in this country is noise Itandapos s not surprising then that noise induced hearing loss NIHL is the second most common form of sensorineural hearing deficit behind only age related hearing loss presbycusis Although therapeutics that target the free radical pathway have shown promise for reducing NIHL there are no effe ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Theranostics of Reduction of Cardiotoxicity Using Targeted Apoptosis Activation Technology

    SBC: Sci-Engi-Medco Solutions, Inc            Topic: 102

    Project Summary Abstract Chronic cardiotoxicity is a clinically unresolved issue for cancer patients who are treated particularly with anthracycline based drugs Currently triple negative breast cancer TNBC patients have no option but to rely on these nonspecific chemotherapeutics New technologies are needed to reduce the off target toxicity including anthracycline related cardiotoxicity A ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Development of Fibrin Specific Nuclear Probe to Reduce LVAD Adverse Events

    SBC: CAPELLA IMAGING, LLC            Topic: NHLBI

    Despite the myriad major advances in cardiology the prognosis for patients with severe medically refractive heart failure HF is exceedingly poor Approximately deaths occur annually in patients with HF who have endured an impaired quality of life often accompanied by significant economic and personal losses due to recurrent hospitalizations At least of these deaths were directl ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Human Apyrase Therapy for Acute Ischemic Stroke

    SBC: APT THERAPEUTICS, INC.            Topic: 105

    Principal Investigator Program Director Last First Middle Chen Ridong Abstract There remains a crucial unmet medical need in acute ischemic stroke AIS treatment Approximately of patients die within one year and are permanently disabled making AIS the fourth leading cause of death and the leading cause of adult disability in the USA with an estimated cost range of $ ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  7. Developing Testing and Validating a Wearable Alcohol Biosensor

    SBC: Clinitech, LLC            Topic: 450

    PROJECT SUMMARY This application for a Phase I SBIR award represents a collaboration between Clinitech LLC and McLean Hospital Harvard Medical School to develop a wearable biosensor for detecting alcohol in the interstitial fluid of humans who have consumed alcohol Excessive use of alcohol accounts for much of the public health burden related to alcohol use disorders including fetal ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Develop a new cisplatin based drug combination with reduced ototoxicity

    SBC: GATEWAY BIOTECHNOLOGY, INC.            Topic: NIDCD

    PROJECT SUMMARY In spite of recent new drug developments platinum based drugs such as cisplatin are still widely used to treat solid organ malignancies Besides its limited efficacy serious side effects have been associated with the use of cisplatin such as bilateral and irreversible hearing loss In the cochlea cisplatin can trigger the production of reactive oxygen species and activate sev ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Developing novel immunoassays specific for thyroid stimulating and TSH blocking autoantibodies

    SBC: MEDIOMICS, LLC            Topic: 200

    Graves disease GD is the most common cause of hyperthyroidism accounting for to percent of more than million cases of hyperthyroidism globally It is an autoimmune disorder caused by thyroid stimulating antibodies TSAbs which bind to the thyrotropin or thyroid stimulating hormone TSH receptor on the surface of a thyroid cell This leads to stimulation of the thyroid gland and ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. ITK TXK Inhibitors as Oral Immunotherapeutic Drugs for Psoriasis

    SBC: CONFLUENCE LIFE SCIENCES, INC.            Topic: NIAMS

    Psoriasis is a devastating autoimmune disease that manifests itself in the form of patchy inflammatory skin lesions that can appear anywhere throughout the body resulting in tremendous physical pain and discomfort This chronic disease can also cause arthritic joints and have a profound impact on a patient s psychological well being In psoriatic lesions the detection of increased numbers of T c ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health

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