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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Biocatalytic production of precursors to lutein and zeaxanthin to address age related macular degeneration

    SBC: EscaZyme Biochemicals, LLC            Topic: N

    Project Summary Atrophic dry age related macular degeneration AMD is the leading cause of severe loss of vision for those over age Dietary supplements containing lutein and zeaxanthin are recommended by the NEI for those at risk of late AMD There has been a corresponding growth in demand for these two xanthophylls Lutein and zeaxanthin are currently sourced from marigolds grown mostl ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Telehealth Intervention for Improved Blood Pressure Control with Targeted Incentives Using New Technologies and Insights From Behavioral Economics to Increase the Effectiveness of Behavioral Change

    SBC: Wellth Inc.            Topic: NIA

    PROJECT SUMMARY ABSTRACT Hypertension or sustained systolic and diastolic blood pressure BP of and mm Hg or higher is among the most frequently encountered conditions in primary care in the U S The estimated prevalence is among all U S adults and increases with age to affect of seniors Hypertension is also the leading risk factor for cardiovascular disease global mortality ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Isolation and characterization of a primary breast epithelium transforming agent

    SBC: SkinAxis LLC            Topic: 102

    Abstract Breast cancer BC is the most common cancer among women Viruses have long been suspected as a cause of breast cancer However despite the identification of virions in human BC cells and human milk and numerous studies that suggest possible connection between breast cancer and Epstein Barr virus EBV mouse mammary tumor virus MMTV and human papilloma virus HPV the tumorigenic po ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. A practical and versatile high resolution D dosimetry system for clinical use

    SBC: HEURIS INC.            Topic: 102

    Quality assurance QA is a critical component of radiation oncology that ensures both effective treatment delivery and patient safety Over the last decade dQA is now particularly important asramatic innovations in treatment delivery technologiesy have led to increasingly sophisticated and complex treatments that are difficult to adequately verify with conventional dosimetric verification system ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. An Improved Method of Delivering a Sclerosing Agent for the Treatment of a Malignant Pleural Effusion

    SBC: TDL Innovations, LLC            Topic: 102

    Project Summary We are developing an improved clinical method to treat patients with malignant pleural effusions A pleural effusion is an abnormal build up of fluid in the pleural cavity the fluid space that surrounds the lungs These malignant pleural effusions MPE occur in patients in the US each year affecting between to of all cancer patients Management of a MPE is p ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Method for High Throughput Assembly of Long DNA Fragments in vitro

    SBC: PHARMASEQ, INC            Topic: 200

    SUMMARY The main project goal is to develop principles and demonstrate the feasibility of a fast in vitro method that will increase the length of synthetic double stranded DNA from its current limit of about kb to kb This in turn will facilitate the ability to more rapidly create artificial genes and chromosomes and thus become an important tool in synthetic biology The proposed approac ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Small Molecule Therapy for the Treatment of Heart Failure

    SBC: SUMOCOR LLC            Topic: NHLBI

    ABSTRACT The incidence of heart failure HF continues to increase in the United States despite significant advances in pharmacological therapies and novel devices There is an acute need for novel treatment strategies for heart failure A key abnormality in HF is defective handling of calcium that has been partially related to abnormal sarcoplasmic reticulum SR function in cardiac myocytes Red ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Development of a novel combination of anti septic taurolidine encased in a digestible nanoparticle system for use as topical treatment at burn sites

    SBC: CorMedix Inc.            Topic: 300

    ABSTRACT Burn injury care has improved in the past decades but complications still occur and lead to prolonged hospital stays and potentially to death The risk of infection rises as a result of burns since the skin layers which function as a barrier and prevent pathogens from accessing the susceptible body tissues are no longer intact Importantly infections involving gram negative or gram po ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Vaginal Tactile Imager for Pelvic Floor Biomechanical Assessment

    SBC: ARTANN LABORATORIES, INC.            Topic: N

    Pelvic organ prolapse POP is a highly prevalent condition affecting over of women in the US during their lifetimes Urinary incontinence UI affects an estimated of women Both POP and UI are more common in women than in men and their prevalence is increased with age Some loss of utero vaginal support occurs in most adult women however the true etiology of prolapse and differences se ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  10. EVVS Endoscopic Venous Valve System

    SBC: VENARUM MEDICAL, LLC            Topic: NHLBI

    Project Summary Abstract Venarum Medical LLC Venarum proposes to validate the Endoscopic Venous Valve System EVVS a novel patent pending valve replacement solution for serious complications of chronic venous disease CVD such as chronic venous insufficiency CVI and specifically dysfunctional venous valves This device is based on the principle that a nitinol stent like scaffold embe ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health

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