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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Modular antibody engineering to overcome the blood brain barrier

    SBC: Abzyme Therapeutics, LLC            Topic: 105

    Abstract Immunotherapy is one of the most promising approaches for treatment of various human diseases including cancers autoimmune and infectious diseases However systemic immunotherapies have been ineffective for central nervous system CNS disorders because the blood brain barrier BBB limits their delivery to the brain Development of new antibody agents able to overcome the BBB is a new ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Biocatalytic production of precursors to lutein and zeaxanthin to address age related macular degeneration

    SBC: EscaZyme Biochemicals, LLC            Topic: N

    Project Summary Atrophic dry age related macular degeneration AMD is the leading cause of severe loss of vision for those over age Dietary supplements containing lutein and zeaxanthin are recommended by the NEI for those at risk of late AMD There has been a corresponding growth in demand for these two xanthophylls Lutein and zeaxanthin are currently sourced from marigolds grown mostl ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Telehealth Intervention for Improved Blood Pressure Control with Targeted Incentives Using New Technologies and Insights From Behavioral Economics to Increase the Effectiveness of Behavioral Change

    SBC: Wellth Inc.            Topic: NIA

    PROJECT SUMMARY ABSTRACT Hypertension or sustained systolic and diastolic blood pressure BP of and mm Hg or higher is among the most frequently encountered conditions in primary care in the U S The estimated prevalence is among all U S adults and increases with age to affect of seniors Hypertension is also the leading risk factor for cardiovascular disease global mortality ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Isolation and characterization of a primary breast epithelium transforming agent

    SBC: SkinAxis LLC            Topic: 102

    Abstract Breast cancer BC is the most common cancer among women Viruses have long been suspected as a cause of breast cancer However despite the identification of virions in human BC cells and human milk and numerous studies that suggest possible connection between breast cancer and Epstein Barr virus EBV mouse mammary tumor virus MMTV and human papilloma virus HPV the tumorigenic po ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Ultra High Content Analysis UHCA of Single Cells in Tissue channel immunofluorescence labeling kits and companion imaging software for everyone

    SBC: Quantitative Imaging Systems, LLC            Topic: 102

    We propose to create a modular suite of products that will make highly multiplexed imaging of individual cells in intact tissue available to a wide range of laboratories through validated labeling kits and companion imaging software that promotes discovery through interactive image and data visualization Our goal is to create a suite of integrated labeling display and analysis products to elucid ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Advancing and calibrating anisotropic diffusion MR imaging brain connectome with Taxon brain network diffusion phantoms

    SBC: Psychology Software Tools, Inc.            Topic: 105

    This project will provide the first ground truth connection anisotropic diffusion phantom to reproduce human white matter using axon scale diffusion tubes and track micron scale fascicle bundles of axons with a common path The phantom will advance MR diffusion imaging providing accurate calibration quality assurance and research advancement It utilizes innovations in textile engineering ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Biodegradable gold nanoparticles as contrast agents for CT

    SBC: PolyAurum LLC            Topic: NIBIB

    PROJECT SUMMARY Computed tomography is used in about million imaging studies per year in the USA Iodinated contrast agents are used in roughly half of these studies Computed tomography is particularly important for the diagnosis of coronary artery disease where it depends on the use of iodinated contrast agents to visualize the arteries However these agents have a number of shortcomings s ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. A practical and versatile high resolution D dosimetry system for clinical use

    SBC: HEURIS INC.            Topic: 102

    Quality assurance QA is a critical component of radiation oncology that ensures both effective treatment delivery and patient safety Over the last decade dQA is now particularly important asramatic innovations in treatment delivery technologiesy have led to increasingly sophisticated and complex treatments that are difficult to adequately verify with conventional dosimetric verification system ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. An Improved Method of Delivering a Sclerosing Agent for the Treatment of a Malignant Pleural Effusion

    SBC: TDL Innovations, LLC            Topic: 102

    Project Summary We are developing an improved clinical method to treat patients with malignant pleural effusions A pleural effusion is an abnormal build up of fluid in the pleural cavity the fluid space that surrounds the lungs These malignant pleural effusions MPE occur in patients in the US each year affecting between to of all cancer patients Management of a MPE is p ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Small molecule ubiquitin ligase modulators for immunotherapy of cancer

    SBC: Progenra, Inc            Topic: 102

    Abstract An exciting and promising new avenue for cancer treatment is the inhibition of immune evasion the employment by tumors of various strategies to suppress the host immune system s ability to recognize and destroy cancer cells Immunotherapies including monoclonal antibodies transplanted stem cells and engineered T cells vaccines cytokines and T cell checkpoint blockers have shown ef ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health

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