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DESCRIPTION provided by applicant B cell lymphoma is cancer of B lymphocytes and accounts for more than deaths in the U S each year While many patients respond to currently available therapy there is a high rate of cancer relapse and inability for the patients o tolerate chemotherapy Thus there is a significant need to make available to these patients newer therapies that are more e ...

DESCRIPTION provided by applicant Nearly half of all college students have a diagnosable mental health problem Blanco et al College counseling centers CCCs are faced with increasing demands for services from Universities students and parents to meet the treatment needs of their students Kay and Schwartz in the context of increasingly severe cases and declining resources ...

DESCRIPTION provided by applicant The specific aim of this Phase IIb Phase II competitive renewal SBIR proposal is to advance the prototype systems we developed under our Phase II grant into commercial production Our product will be used to automatically track samples in laboratory and biobank freezers Most of these samples are stored in vials Between and million such vials are ...

DESCRIPTION provided by applicant The identification and quantification of specific proteins in complex samples are critical processes in discovering understanding and ultimately addressing the underlying nature of human health and disease The western blot is a fundamental method used for these processes due to the sensitivity and specificity enabled by combining protein sizing with immuno ...

DESCRIPTION provided by applicant The product is a slide coated with silica colloidal crystals to combine protein electrophoresis with matrix assisted laser desorption ionization mass spectrometry MALDI MS detection giving superior performance in both The Phase II proposal will be to develop an instrument for facile application of the slide in proteomics of intat glycoproteins This propos ...

DESCRIPTION provided by applicant Duchenne Muscular Dystrophy DMD is a fatal muscle disease affecting in every male births DMD results from mutations in the gene encoding the dystrophin a kDa scaffolding protein responsible for providing a mechanical link between the muscle fiber actin cytoskeleton and a transmembrane protein complex called the dystrophin associated glycoprotein ...

DESCRIPTION provided by applicant The number of Lyme disease cases in the US has been recently estimated by the CDC at cases year This is major public health concern Currently available diagnostics rely on detection of the antibody response serology to Borrelia burgdorferi the causative agent of Lyme disease However serological tests are not accurate during the early stages of Ly ...

DESCRIPTION provided by applicant The Specific Aim of this proposal is to test the feasibility of developing utilizing and evaluating a web based diabetes self management support DSMS training program that is culturally tailored for the African American community Effective self management is the key to improving diabetes outcomes avoiding complications and reducing costs Ongoing mainte ...

DESCRIPTION Age Related Macular Degeneration ARMD afflicts andgt of the andgt population andgt of US visually impaired population is andgt within this ARMD is the largest cause of impairment A primary feature of ARMD is inability to adapt between light dark L D leading to loss in functional vision indoors outdoors There is currently no proven practical noninvasive m ...

DESCRIPTION provided by applicant Bleeding control during brain surgery is of utmost importance as uncontrolled bleeding inside the confined intracranial space can quickly degenerate into debilitating complications and death Ligature is usually not possible in the brain due both to the small size of the vessels and the delicacy of the tissue as the majority of bleedings during neurosurgery is ...