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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Biocatalytic production of precursors to lutein and zeaxanthin to address age related macular degeneration

    SBC: EscaZyme Biochemicals, LLC            Topic: N

    Project Summary Atrophic dry age related macular degeneration AMD is the leading cause of severe loss of vision for those over age Dietary supplements containing lutein and zeaxanthin are recommended by the NEI for those at risk of late AMD There has been a corresponding growth in demand for these two xanthophylls Lutein and zeaxanthin are currently sourced from marigolds grown mostl ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Early Feasibility Clinical Study of the VitalFlow Stimulator an Emergency Treatment for Ischemic Stroke

    SBC: NERVIVE, INC.            Topic: 105

    PROJECT SUMMARY Stroke is the world s greatest healthcare burden for which few treatment options are available The long term objective of the applicant Nervive Inc is to bring to market a non invasive medical device the VitalFlow stimulator as an emergency treatment for ischemic stroke The VitalFlow is a novel technology that activates the autonomic components of the facial nerve using pul ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Evolution of an Adaptable Prosthetic Foot Design for Normalization of Biomechanics During Community Participation

    SBC: OHIO WILLOW WOOD COMPANY, THE            Topic: NICHD

    Evolution of an Adaptable Prosthetic Foot Design for Normalization of Biomechanics During Community Participation Summary Abstract The vision of this project is to improve the functional physical mobility of people with lower extremity amputations so that they can more fully and confidently participate in a wider range of activities This will enhance their personal satisfaction thereby improving ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. High Resolution Ultrasonic Micro Transducer for In Utero Procedures

    SBC: H-CUBED            Topic: NICHD

    PROJECT SUMMARY The s heralded the advent of fetal surgery bringing forth a new paradigm of treatment for fetuses with significant congenital defects including spina bifida congenital diaphragmatic hernia and complications such as twin twin transfusion syndrome Earlier treatment in the womb allows for natural and continued development within the safety of the uterus improving outcomes for ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Software for OCT Analysis of Vascular Stents

    SBC: Dyad Medical, Inc.            Topic: NHLBI

    Software for OCT Analysis of Vascular Stents PI Ronny Shalev PhD Dyad Medical Summary Dyad Medical Inc will create intravascular OCT IVOCT software for clinical live time determination of stent apposition OCTivat live the live time OCT image visualization and analysis tool and for offline analysis of stent implantation OCTivat stent Every year s of thousands of patients in the US ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Developing Testing and Validating a Wearable Alcohol Biosensor

    SBC: Clinitech, LLC            Topic: 450

    PROJECT SUMMARY This application for a Phase I SBIR award represents a collaboration between Clinitech LLC and McLean Hospital Harvard Medical School to develop a wearable biosensor for detecting alcohol in the interstitial fluid of humans who have consumed alcohol Excessive use of alcohol accounts for much of the public health burden related to alcohol use disorders including fetal ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Phage accelerated test system for ID AST of urinary tract infections

    SBC: GUILD ASSOCIATES, INC.            Topic: R

    Urinary tract infections UTIs are one of the most common types of bacterial infection encountered by humans throughout their lifespan and are a major health problem afflicting millions of people each year Gram negative bacteria cause the majority of infections of which Escherichia coli is the primary pathogen and prone to antibiotic resistance The standard methods for species diagnosis and sus ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. A Novel Non Cytotoxic Epigenetic Therapeutic for Sickle Cell Disease

    SBC: DeNovoTherapies LLC            Topic: NHLBI

    ABSTRACT The goal of this Fast Track proposal is to develop a novel non cytotoxic epigenetic therapeutic for life long disease modification of sickle cell disease SCD SCD is a morbid life shortening condition caused by mutated hemoglobin sickle hemoglobin HbS The pathophysiology triggered by sickle hemoglobin is interrupted by another hemoglobin that the body usually produces in utero fe ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Localized Statin Delivery for Prevention of Primary AV Fistula Failure

    SBC: AFFINITY THERAPEUTICS, LLC            Topic: NHLBI

    Abstract Summary Arteriovenous fistulas AVFs are the preferred vascular access mode for hemodialysis patients but of AVFs fail to mature and only of mature AVFs are patent after year Vascular access failure including AVFs results from neointimal hyperplasia and contributes to andgt $ billion USD annual costs from vascular access failure including of hemodialysis patient hosp ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. HLS Durable Implantable Non Obstructive Venous Assist Device NOVAD for Support of Cavopulmonary Fontan Circulation

    SBC: Perfusion Solutions, Inc.            Topic: NHLBI

    Project Summary Abstract The proposal addresses NHLBI Topic of Special Interest HLS Development of mechanical circulatory support devices for individuals with congenital heart disease and single ventricle physiology after Fontan surgical palliation The design was specifically stimulated by the requirements outlined to Perfusion Solutions Inc PSI by pediatric and congenital surgeon Dr P ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health

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