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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Affordable, quantitative, point-of-care microchip-electrophoresis for screening and treatment monitoring of sickle cell disease, thalassemias, and anemias

    SBC: HEMEX HEALTH INC            Topic: NHLBI

    PROJECT SUMMARY Anemia is characterized by low blood hemoglobin levels and has a high prevalence, affecting over one-third of the world's population of about 2.5 billion people. More than 7% of the world’s population carry hemoglobin gene mutations that result in hemoglobin variants, one of which is Sickle Cell Disease (SCD). SCD impacts about 100,000 Americans. The trait form of SCD is the Sick ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  2. Using epigenetic science to improve environmental health literacy

    SBC: NZUMBE INC            Topic: R

    Project Summary NIEHS defines environmental health as “the field of science that studies how the environment influences human health and disease”. The environment in this definition includes the natural environment, man-made chemicals and structures that often pollute the natural environment, and our social interactions and lifestyle choices. Because toxic environments are linked directly to h ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  3. High-throughput functional analysis and clinical relevance of all possible variants of a gene

    SBC: HELIGENICS, INC.            Topic: NHGRI

    Modern pharmaceuticals have greatly improved the quality of life for many patients suffering a variety of illnesses. Unfortunately, among the 17 most commonly prescribed drugs, only 6 are highly effective for most patients, 5 have a modest effect, and 6 show little clinical effect. Worse still, unwanted illness and death from treatment of patients with the incorrect drug or dosage causes over 275, ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  4. Development, feasibility, and acceptability of Aim to Play, a user-friendly digital application for teacher skills training and physical education activities for K-2 elementary students

    SBC: SAAVSUS INC            Topic: 102

    ABSTRACTFundamental movement skill (FMS) is an integral component to holistic child development and school readiness. Serious inequalities in physical activity participation and FMS development are associated with race/ethnicity, income, and school contexts, which further exacerbate health disparities and academic vulnerability among disadvantaged children. Children from low-income, minority, and ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  5. Validation and Improvement of ISPRI-HCP: An Innovative Platform for Immunogenicity Risk Assessment of Process-related Protein Impurities

    SBC: EPIVAX, INC.            Topic: NIAID

    ABSTRACT The identification and removal of process-related protein impurities (PRPI) from biologic products is a critical step in drug development. Despite recent improvements in the purification and processing of biologics, the presence of immunogenic PRPI continue to raise concerns about drug safety and efficacy. We propose an innovative approach for assessing immunogenicity risk of PRPI using o ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  6. Development of a rapid, scalable, and deployable point-of-care blood volume diagnostic for monitoring postpartum and trauma-related hemorrhage

    SBC: QUANTIPORT, INC.            Topic: NHLBI

    ABSTRACT Postpartum hemorrhage (PPH) is the leading cause of maternal mortality globally, accounting for 1/4th of all delivery-associated deaths. PPH is described as the cumulative blood loss of 1L or more with symptoms of hypovolemia within 24 hours after giving birth. Recently, reports have demonstrated that about 53-93% of PPH- related deaths could have been prevented by administering timely me ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  7. Two-Color Near-Infrared Fluorescence Guided Surgery Tools Enabling Simultaneous Cancer Margin and Nerve Visualization during Head and Neck Squamous Cell Carcinoma Resection

    SBC: TRACE BIOSCIENCES INC            Topic: 102

    PROJECT SUMMARYHead and neck squamous cell carcinoma (HNSCC) is the sixth highest incidence cancer worldwide, with rt650,000 cases annually. Surgery is a primary treatment option for HNSCC, during which surgeons face two main goals: 1) complete cancer resection and 2) preservation of normal tissue structures such as muscle, blood vessels, and nerves to ensure post-surgical quality of life. Unfortu ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  8. VisitBoost: A Home Visiting Enhancement to Reduce Harm for Families Affected by Substance Misuse

    SBC: OREGON RESEARCH BEHAVIORAL INTERVENTION STRATEGIES, INC.            Topic: NIDA

    Project Summary Stigmatization of people with substance use disorders (SUD) during perinatal results from the toxic belief that people who use substances are incapable of being good parents and do not care about their children. This belief perpetuates cyclical and systemic harm towards people with SUD and their children. Home visiting programs are less likely to sustain engagement with parents wit ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  9. A Digital Health Technology to Prevent Family Violence and Improve Child Mental Health

    SBC: Northwest Prevention Science Inc.            Topic: 104

    7. Project Summary/Abstract The COVID-19 pandemic has increased the need for eHealth interventions that target families and children at- risk of family violence and long-term mental health problems. Escalating rates of anxiety and depression during COVID-19 have impacted families adversely, and have led to impaired parent-child relationships and increased family conflict (Russell et al., 2020). Th ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  10. MomNet: Development of a Coach-Training Program for an Empirically Supported, Guided ehealth Intervention for Depressed Mothers

    SBC: OREGON RESEARCH BEHAVIORAL INTERVENTION STRATEGIES, INC.            Topic: 104

    Project Summary/Abstract Economically disadvantaged mothers of young children experience disproportionately high rates of depressive symptoms, yet often do not receive treatment due to instrumental and psychological barriers. Remission of maternal depression relates to improvements in both parenting behavior and child functioning, suggesting that treatment of maternal depression has the potential ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
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