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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Feasibility and proof of concept of a dense, low cost, network of sensors driving Intelligent building Agents for air quality and energy control.

    SBC: XMARK LABS, LLC            Topic: 6

    Commercial buildings use 35% of the entire US energy output, and up to a third of that energy is wasted. Rapidly rising fuel costs, increasing concern about climate change, and policy directives from the Biden Administration are all driving the need for increased energy efficiency and the elimination of waste. At the same time, the COVID-19 pandemic has dramatically increased public awareness of t ...

    SBIR Phase I 2023 Department of CommerceNational Institute of Standards and Technology
  2. Optimizing Small Molecule Mechanomimetics to Treat Age-related Osteoporosis.

    SBC: OAK RIDGE THERAPEUTIC DISCOVERY LLC            Topic: NIA

    Abstract There is an unmet need to develop treatments for senile osteoporosis, a disorder characterized by an age-related reciprocal decrease in osteogenesis and increase in bone marrow fat. Senile osteoporosis resembles disuse osteopenia, suggesting its pathogenesis involves impaired bone mechanosensing. We discovered that the polycystin heterotrimeric complex (1PC1+3PC2) functions as a mechanose ...

    STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  3. Inter-alpha Inhibitors in Experimental Necrotizing Enterocolitis

    SBC: PROTHERA BIOLOGICS, INC.            Topic: NICHD

    Necrotizing enterocolitis (NEC) is a devastating acute inflammatory condition of the gastrointestinal tract resulting in intestinal necrosis, systemic sepsis and multi-system organ failure found mostly in infants born prematurely. Despite modern medical advances in the past decade, the etiology remains elusive and morbidity and mortality are still unacceptably high. It has been concluded that the ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  4. Developing a selective TRPC3 ion channel inhibitor for epilepsy treatment

    SBC: SEAK Therapeutics, LLC            Topic: 106

    Project SummaryEpilepsy is one of the most common brain disorders. Current drugs have limited efficacy. Identifying new targeted drugs that can be used as safer, more effective therapies is in urgent unmet need. Selective inhibition of the transient receptor potential canonical 3 (TRPC3) emerges as a novel strategy to impede epilepsy. However, the currently best selective TRPC3 inhibitor, Pyr3, ha ...

    STTR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  5. Real-time Multimodal Diffuse Reflectance and Polarization Imaging Based Nerve Identification in Surgical Field of View

    SBC: YAYA SCIENTIFIC LLC            Topic: NIBIB

    PROJECT SUMMARY We propose to develop a novel non-contact, label-free multimodality imager that provides real-time intraoperative identification of nerves within the surgical field-of-view to facilitate the prevention of unintended nerve damage (termed iatrogenic nerve injury) during surgical procedures, as they are a major source of postsurgical complications, e.g., chronic pain. In the United St ...

    STTR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  6. Optimization of an integrin enhancing molecule for the treatment of Duchenne muscular dystrophy

    SBC: STRYKAGEN CORPORATION            Topic: 100

    Abstract Duchenne Muscular Dystrophy (DMD) is a fatal muscle disease with an incidence of 1 in 5000 males. DMD results from mutations in the gene encoding dystrophin, a 427 kDa scaffolding protein responsible for providing a mechanical link between the muscle fiber actin cytoskeleton and laminin in the extracellular matrix. The α7β1 integrin is a transmembrane linkage system in skeletal and card ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  7. A Robotic System to Remove Bladder Tumors Intact: The Key to Making Lifesaving Treatment Decisions

    SBC: VIRTUOSO SURGICAL, INC.            Topic: NIBIB

    Project Summary/Abstract: The objective of this proposal is to create a new robotic system that enables bladder tumors to be removed completely and intact. Currently they are removed piecemeal, which spreads cancer cells, and results in incon- clusive diagnosis and staging, which dramatically increases morbidity and mortality for patients. Our system will deliver two needle-sized, tentacle-like ar ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  8. Cognitive Behavioral Immersion: A Randomized Control Trial of Peer-Based Coaching in the Metaverse

    SBC: Very Real Help, LLC            Topic: 104

    PROJECT SUMMARY/ABSTRACT Depression and anxiety rank among the largest public health burdens worldwide. While effective first-line treatments like cognitive behavioral therapy have been shown to be effective, there are numerous barriers to accessing this kind of clinician delivered care (e.g., cost, provider availability, stigma). There is a critical need for effective and affordable interventions ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  9. Inter-alpha Inhibitors in Hypoxic-Ischemic Brain Injury

    SBC: PROTHERA BIOLOGICS, INC.            Topic: 105

    Perinatal brain injury resulting in mental retardation and cerebral palsy is the most severe disability in children and affects 40-148 in preterm and 1–2/1000 in full term infants. This places a huge burden on society, emphasizing the critical need for improved prevention/treatment strategies to decrease perinatal brain injury. Hypothermia (HT) is the only FDA approved therapy to attenuate brain ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  10. Precision Guidance of Resuscitation and Deresuscitation in Sepsis

    SBC: DAXOR CORPORATION            Topic: 300

    ABSTRACT Sepsis impacts 1.7 million Americans annually, leading to 270,000 deaths and $62 billion in costs. Most of the sepsis treatment follows the Surviving Sepsis Campaign (SSC) guidelines, consisting of early antibiotics, liberal fluid resuscitation, and vasopressor use in persistent hypotension. However, the fundamental assumption that sepsis universally results in high capillary leak leading ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
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