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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. SnapCap: a device to decontaminate central venous catheters (CVC) with 5 snaps

    SBC: Contech Medical, Inc.            Topic: NICHD

    Project Summary Abstract We propose a new approach to the decontamination of central venous catheters and the prevention of central line associated bloodstream infectionsCLABSIan important healthcare associated infectionCLABSIs cost the US healthcare system approximately $billion annuallyPronovostNEJMAdditionallyCLABSIs can be life threateningespecially in the very young and critically illEven whe ...

    STTR Phase I 2018 Department of Health and Human Services
  2. Caring for the Caregiver: A Theory-Driven Mobile Intervention to Promote Caregiver Well-Being

    SBC: Pro-Change Behavior Systems Inc            Topic: NIA

    Overmillion Americans are currently providing unpaid care to a family memberrelativeor friend with Alzheimer s disease or related dementiaWhile caregiving can be a positive experience that brings meaning and an increased sense of purposeit can also take a tollNearlyof Alzheimer s and dementia caregivers rate their emotional distress as high or very highand as many assuffer from depressionCaregiver ...

    SBIR Phase I 2018 Department of Health and Human Services
  3. Targeting DNA damage response pathways for the treatment of advanced lung cancer


    ABSTRACTThere is an urgentunmet need for novel therapeutic approaches that are efficacious against lung cancerRanking first among cancer deaths in the U Sthis disease hasyear relative survival rates of andltMost lung cancers are non small cellNSCLCof casesCurative surgery is not an option for theof NSCLC patients who present with advanced stage III cancerFor these patients chemo radiation therapy ...

    SBIR Phase II 2018 Department of Health and Human Services
  4. Rapid Test to Assist Therapy in Neonatal Sepsis and Necrotizing Enterocolitis

    SBC: PROTHERA BIOLOGICS, LLC            Topic: R

    The primary goal of this proposed research is to develop a rapid point of care test that assesses the risk of neonatal sepsisNSand or necrotizing enterocolitisNECin infants based on Inter alpha inhibitor proteinsIAIPlevels in bloodThe test is expected to be simpleuser friendlyportable and suitable for use in the NICUNS and NEC are associated with high mortality and morbidityincluding adverse neuro ...

    SBIR Phase I 2018 Department of Health and Human Services

    SBC: Synchro Motion LLC            Topic: NICHD

    PROJECT SUMMARY A conventional prosthetic ankle consists of a carbon fiber ankle foot complex that is nominally configured to a neutral positionThese prostheses generally work well for level walking and level ground standingbut lack the adaptability to explicitly accommodate other terrain or locomotion activitiessuch as slope walkingslope standingand stair ambulationAs suchcommon activities with a ...

    SBIR Phase I 2018 Department of Health and Human Services
  6. A Molecular Diagnostic Assay for Accurately Differentiating Melanoma from Benign Lesions

    SBC: Frontier Diagnostics, LLC            Topic: 102

    AbstractMelanoma is the third most common form of skin cancer with estimatednew cases diagnosed in the United States in the yearCurrent routine diagnostic approaches utilize microscopic evaluation of thinly sectioned patient biopsiesbut in certain cases diagnosis can be contentious even among expertsThe overall goal of this multi phase SBIR project is to developvalidateand commercialize MelanoMapT ...

    SBIR Phase I 2018 Department of Health and Human Services
  7. Non-Invasive Venous Waveform Analysis (NIVA) in patients with Heart Failure (HF)

    SBC: Volumetrix, LLC            Topic: NHLBI

    Volume overloadcongestionoccurs in patients with heart failureHFand is the leading cause of hospitalization in the elderly worldwideUnfortunatelyclinical signs and symptomslaboratory valuesand existing diagnostic tools are unreliable in providing accurate assessment of volume statusUsing a unique physiologic signalNon Invasive Venous waveform AnalysisNIVAVoluMetrix has developed a proprietary devi ...

    SBIR Phase I 2018 Department of Health and Human Services
  8. HLS Potent, novel inhibitor of fibrinolytic hemorrhage- Phase II

    SBC: Translational Sciences Inc.            Topic: NHLBI

    This SBIR Application is responsive to NHLBI Small Business Topics of Special Interesttherapeuticsthat are of high programmatic interestHLSHemorrhage or bleeding is a serious or fatal complication of surgeryAntifibrinolytic agents that inhibit plasmin mediated fibrinolysis can significantly reduce blood lossemergency reoperationmorbidity and death in patients with severe hemorrhageAntifibrinolytic ...

    SBIR Phase II 2018 Department of Health and Human Services
  9. Autonomously-activating bioluminescent reporters to enable continuous, real-time, non-invasive brain cell imaging

    SBC: 490 BIOTECH INC            Topic: 101

    Autonomously activating bioluminescent reporters to enable continuousreal timenoninvasive brain cell imaging Project Summary This Small Business Innovation ResearchSBIRPhase I project proposes to develop a set of genetically encodedself exciting bioluminescentautobioluminescentoptical imaging reporters that will enable continuous neuron and astrocyte specific imaging without perturbing endogenous ...

    SBIR Phase I 2018 Department of Health and Human Services
  10. Galectin-1 Protein Therapy for Congenital Muscular Dystrophy


    Abstract Lamininrelated congenital muscular dystrophyLAMACMDalso known as Merosin Deficient Congenital Muscular DystrophyMDC Ais a fatal muscle wasting disease that affects patients from birthLAMACMD results from mutations in the LAMAgene resulting in loss of lamininproteinLamininis required for the formation of the heterotrimers lamininand lamininwhich are major constituents of the skeletal and c ...

    STTR Phase I 2018 Department of Health and Human Services

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