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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Biocatalytic production of precursors to lutein and zeaxanthin to address age related macular degeneration

    SBC: EscaZyme Biochemicals, LLC            Topic: N

    Project Summary Atrophic dry age related macular degeneration AMD is the leading cause of severe loss of vision for those over age Dietary supplements containing lutein and zeaxanthin are recommended by the NEI for those at risk of late AMD There has been a corresponding growth in demand for these two xanthophylls Lutein and zeaxanthin are currently sourced from marigolds grown mostl ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Improved detection of bladder cancer recurrence using a biophysical biomarker

    SBC: SynderBio Inc.            Topic: 102

    Bladder cancer is the fifth most commonly diagnosed cancer in the United States Three quarters of the nearly men and women diagnosed with bladder cancer just this year will have a less aggressive form of the disease which after treatment will require frequent visits to the urologist for invasive painful cystoscopy procedures for the remainder of their lifetimes to determine if the cance ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Developing Testing and Validating a Wearable Alcohol Biosensor

    SBC: Clinitech, LLC            Topic: 450

    PROJECT SUMMARY This application for a Phase I SBIR award represents a collaboration between Clinitech LLC and McLean Hospital Harvard Medical School to develop a wearable biosensor for detecting alcohol in the interstitial fluid of humans who have consumed alcohol Excessive use of alcohol accounts for much of the public health burden related to alcohol use disorders including fetal ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. The use of Organizer Software for secure team based clinician to clinician communication to improve recipient outcomes for solid organ donation cases

    SBC: Healthtech Solutions, Inc.            Topic: NLM

    Organ transplantation is a complex process requiring effective coordination and communication amongst a highly distributed network of providers within a short window of time in order for a successful transplantation to occur However Fewer than of authorized donated organs are transplanted successfully and over patients in the US are waiting for a transplant with patients dying ev ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Improved preparation of cell suspensions for single cell genomics

    SBC: SynderBio Inc.            Topic: 172

    Summary Single cell sequencing SCS is a disruptive new technology that offers an unprecedented ability to interrogate the genomics DNA RNA of single cells to understand the complex biologies of normal and diseased tissues SCS is not only important for basic research but also represents a next generation of diagnostic approaches particularly for cancer While multiple SCS platforms have bee ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Mol An interactive learning platform to address difficult concepts in organic chemistry

    SBC: Substrate Games, LLC            Topic: 500

    In this NIH Phase I SBIR project we propose to develop and evaluate a proof of concept for Mol a mobile STEM game to address difficult to learn topics in organic chemistry Our first module will focus on stereochemistry a notoriously challenging concept facing nearly million undergraduate students each year who are pursuing a healthcare career and another million biology and chemistry stude ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. HLS Potent novel inhibitor of fibrinolytic hemorrhage

    SBC: Translational Sciences Inc.            Topic: NHLBI

    This SBIR Application is responsive to NHLBI Small Business Topics of Special Interest therapeutics that are of high programmatic interest HL Hemorrhage or bleeding is a serious or fatal complication of surgery Antifibrinolytic agents that inhibit plasmin mediated fibrinolysis can significantly reduce blood loss emergency reoperation morbidity and death in patients with severe hemor ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Enabling point of care molecular diagnostics by developing an adaptive PCR instrument and on demand kit reagents

    SBC: BIOVENTURES, INC            Topic: 172

    Because of its high sensitivity polymerase chain reaction PCR is the gold standard for the diagnosis of many infectious diseases but generally only implemented in well equipped laboratories One of the major roadblocks for expanding PCR to point of care markets is the lack of simple robust single tube PCR designs which preserve its laboratory based high sensitivity and specificity In this F ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Long non coding RNA signatures to distinguish fibromyalgia syndrome from rheumatic diseases

    SBC: IQUITY LABS, INC.            Topic: NIAID

    No other group of diseases encompasses a greater pathophysiology than do the rheumatic diseases Spanning multiple organ systems clinical decisions often rely on coordinated efforts from primary care providers and rheumatologists to rule in or rule out differential diagnoses when treating inflammatory conditions such as rheumatoid arthritis RA and systemic lupus erythematosus SLE RA is a sym ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Point of care immunoassay for rapid diagnosis of tinea capitis

    SBC: DxDiscovery Incorporated            Topic: NIBIB

    Tinea capitis scalp ringworm is a fungal dermatophyte infection of scalp hair follicles that afflicts of the U S pediatric population Tinea capitis is a major health care disparity because it occurs predominantly among individuals with a disadvantaged socioeconomic background and sub Saharan African descent Diagnosis of tinea capitis is currently dependent on culture and microscopy Both ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health

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