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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Biocatalytic production of precursors to lutein and zeaxanthin to address age related macular degeneration

    SBC: EscaZyme Biochemicals, LLC            Topic: N

    Project Summary Atrophic dry age related macular degeneration AMD is the leading cause of severe loss of vision for those over age Dietary supplements containing lutein and zeaxanthin are recommended by the NEI for those at risk of late AMD There has been a corresponding growth in demand for these two xanthophylls Lutein and zeaxanthin are currently sourced from marigolds grown mostl ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Low cost portable system for the rapid detection and drug resistance profiling of Tuberculosis in low resource environments

    SBC: Impedx Diagnostics Inc.            Topic: NICHD

    Tuberculosis TB is one of the major public health challenges in the world today with an estimated million deaths in More alarmingly the incidence of multi drug resistant MDR TB is rapidly increasing especially in low resource environments The goal of this project is to develop an inexpensive portable system and method using which it will be possible to both detect the presence of ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Developing Testing and Validating a Wearable Alcohol Biosensor

    SBC: Clinitech, LLC            Topic: 450

    PROJECT SUMMARY This application for a Phase I SBIR award represents a collaboration between Clinitech LLC and McLean Hospital Harvard Medical School to develop a wearable biosensor for detecting alcohol in the interstitial fluid of humans who have consumed alcohol Excessive use of alcohol accounts for much of the public health burden related to alcohol use disorders including fetal ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Precision Microspheres for Transtympanic Delivery of Ganciclovir for CMV Infection

    SBC: ORBIS BIOSCIENCES, INC.            Topic: Y

    PROJECT SUMMARY Current approaches to treat sensorineural hearing loss SNHL in newborns suffering from congenital cytomegalovirus CMV infection rely on off label systemic antiviral therapy requiring high dose long duration treatment with demonstrated hematologic toxicity carcinogenicity and teratogenicity Furthermore it is unknown whether systemic delivery of antivirals maintain inner e ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. HLS Potent novel inhibitor of fibrinolytic hemorrhage

    SBC: Translational Sciences Inc.            Topic: NHLBI

    This SBIR Application is responsive to NHLBI Small Business Topics of Special Interest therapeutics that are of high programmatic interest HL Hemorrhage or bleeding is a serious or fatal complication of surgery Antifibrinolytic agents that inhibit plasmin mediated fibrinolysis can significantly reduce blood loss emergency reoperation morbidity and death in patients with severe hemor ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Enabling point of care molecular diagnostics by developing an adaptive PCR instrument and on demand kit reagents

    SBC: BIOVENTURES, INC            Topic: 172

    Because of its high sensitivity polymerase chain reaction PCR is the gold standard for the diagnosis of many infectious diseases but generally only implemented in well equipped laboratories One of the major roadblocks for expanding PCR to point of care markets is the lack of simple robust single tube PCR designs which preserve its laboratory based high sensitivity and specificity In this F ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Aerosolized platinum nanoparticle chemotherapy for lung cancer

    SBC: HYLAPHARM LLC            Topic: 102

    Significance Lung cancer is the leading cause of cancer deaths with over new diagnoses annually Survival rate of lung cancer patients is correlated with the extent of lymph node metastasis Standard care includes chemotherapy radiation and or surgery Cisplatin is a first line chemotherapy for lung cancer but systemic intravenous IV delivery is confounded by various toxicities rena ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Long non coding RNA signatures to distinguish fibromyalgia syndrome from rheumatic diseases

    SBC: IQUITY LABS, INC.            Topic: NIAID

    No other group of diseases encompasses a greater pathophysiology than do the rheumatic diseases Spanning multiple organ systems clinical decisions often rely on coordinated efforts from primary care providers and rheumatologists to rule in or rule out differential diagnoses when treating inflammatory conditions such as rheumatoid arthritis RA and systemic lupus erythematosus SLE RA is a sym ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Point of care immunoassay for rapid diagnosis of tinea capitis

    SBC: DxDiscovery Incorporated            Topic: NIBIB

    Tinea capitis scalp ringworm is a fungal dermatophyte infection of scalp hair follicles that afflicts of the U S pediatric population Tinea capitis is a major health care disparity because it occurs predominantly among individuals with a disadvantaged socioeconomic background and sub Saharan African descent Diagnosis of tinea capitis is currently dependent on culture and microscopy Both ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  10. Development of Tumor Proliferation PET Tracer FLT using a Low Cost Single Dose Automatic Production and Quality Control Biomarker Generator System

    SBC: ABT Molecular Imaging            Topic: 102

    DESCRIPTION provided by applicant Worldwide a person dies from cancer every seconds Positron emission tomography PET is an effective tool that is critical in diagnosing cancer and monitoring treatment efficacy PET imaging relies on use of short lived radioisotopes Commercial distribution of the most commonly used radio tracer F FDG has resulted in patient population coverage in ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health

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