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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Knowledge and Usage of Lactation using Education and Advice from Support Network KULEA NET

    SBC: Benten Technologies, Inc.            Topic: NIMHD

    PROJECT SUMMARY ABSTRACT Breastfeeding has the potential to reduce health disparities associated with infant mortality and morbidity Breastfeeding rates by ethnicity in the United States show a marked disparity in African American AA women as compared to other groups Barriers to breastfeeding are complex with literature citing a lack of knowledge poor family and social support inhibiting soc ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Biocatalytic production of precursors to lutein and zeaxanthin to address age related macular degeneration

    SBC: EscaZyme Biochemicals, LLC            Topic: N

    Project Summary Atrophic dry age related macular degeneration AMD is the leading cause of severe loss of vision for those over age Dietary supplements containing lutein and zeaxanthin are recommended by the NEI for those at risk of late AMD There has been a corresponding growth in demand for these two xanthophylls Lutein and zeaxanthin are currently sourced from marigolds grown mostl ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. ZeroG TRIP Training Responses in Postural Rehabilitation

    SBC: ARETECH, LLC            Topic: NIA

    Project Summary The goal of this project is to significantly enhance our understanding and treatment of inadequate balance responses in the elderly and in patients with neurological impairments following external perturbations such as a slip or trip Our laboratory studies have shown that balance responses can be improved with practice in the elderly and in patients with Parkinsonandapos s disease ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Poly Metallo Liothyronine Complexes for Hypothyroidism Treatment

    SBC: Synthonics, Inc.            Topic: 200

    The work described in this proposal addresses the clinical deficiency of the currently available oral treatments for hypothyroidism Approximately of persons suffering from hypothyroidism report insufficient symptomatic improvement from levothyroxine T Synthroid alone This is thought to be related to a genetic variation in the enzyme that converts T to T the active form of thyroid hor ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. A highly specific NIRF PET probe for the detection of cancer and metastases

    SBC: Imol Radiopharmaceuticals, LLC            Topic: 393

    This project will explore the translational potential of a new PET molecular imaging probe Ga PC for detecting very small cancers and distinguishing between localized and metastasized cancers in bone and soft tissue mouse models Ga PC will be evaluated for metastatic prostate PC and pancreatic PaCa cancers Early detection of the most lethal PaCa with andlt survival for y ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Self expanding hydrogel for pelvic brachytherapy a novel method for vaginal packing and customized radiation therapy

    SBC: BrachyFoam, LLC            Topic: 102

    This proposal aims to develop a polymer hydrogel strategy that can be used to improve the clinical care of patients receiving brachytherapy for gynecological cancers The biocompatible hydrogel will form in situ after being injected into the vaginal space and later removed by instillation of water to soften the hydrogel for easy extraction This Phase I proposal focuses on optimizing the polymer ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Therapeutic disruption of Connexin mediated microtubule regulation to target glioblastoma cancer stem cells

    SBC: Acomhal Research, Inc.            Topic: 100

    Project Summary Glioblastoma GBM is one of the most lethal incurable human diseases Even with aggressive therapies including surgical resection followed by radiotherapy and chemotherapy using temozolomide TMZ the median survival for GBM patients is only months In fact GBM cancer cells are highly infiltrative and comprise a sub population of glioma stem cells GSCs with tumorigenic pro ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. GRIM for head and neck cancer therapy

    SBC: GLYCOMANTRA INC.            Topic: 102

    Project Summary Many clinical and preclinical studies demonstrated that interferons IFNs exert a superior anti tumor effect when combined with retinoids a class of vitamin A metabolites We identified a novel tumor suppressor Gene associated with Retinoid IFN induced Mortality GRIM by a genome wide knockdown strategy In our recent publication in the PNAS we have shown that GRIM g ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. A cloud based WGS platform for routine surveillance of plasmid borne carbapenem resistance

    SBC: ICBiome            Topic: NIAID

    Plasmid borne carbapenem resistance has become a serious global threat in hospital settings As hospitals face a dwindling number of treatment options there is a great urgency to track the movement of carbapenem resistant plasmids and the associated resistant genes While whole genome sequencing has great diagnostic potential plasmids pose a unique set of challenges as they lack a clear well de ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Small molecule inhibitors for influenza treatment

    SBC: ALEXANDER BIODISCOVERIES            Topic: NIAID

    Influenza is a continuing worldwide public health problem associated with significant morbidity and mortality Seasonal influenza epidemics affect about of the worldandapos s population and annual estimates of mortality range from deaths Due to constant antigenic drift the approved seasonal influenza vaccine is variably effective from year to year and a universal vaccine ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health

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