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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Diagnostics to enable Malaria and Neglected Tropical Diseases

    SBC: HDT Bio Corp.            Topic: NIAID

    The role of HDT Bio is to translate discovery into products for infectious diseasesIn this proposal we focus on producing a diagnostic test to aid in the elimination of leprosyWe will develop LepReactan improved and cost effective diagnostic intradermal skin test to permit screening for Mycobacterium leprae infectionLeprosy is a severe neurological disease caused by infection with Mlepraeand devel ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  2. A Novel Adjuvant-based Probiotic Platform for Generating Tolerance Therapeutics

    SBC: VIRTICI LLC            Topic: NIAID

    Autoimmune and allergic diseases affect overof the world population and are continuing to riseOur goal is to develop a novel adjuvant based probiotic platform to rapidly create tolerance inducing therapeutics for the treatment of allergy and autoimmune diseaseFor thiswe will leverage the reovirus protein sigmapwhich is a powerful tolerance adjuvantFusion proteins consisting of pwith an antigen of ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  3. Correlating TCR diversity to immune reconstitution after cord blood transplant

    SBC: ADAPTIVE BIOTECHNOLOGIES CORPORATION            Topic: NHLBI

    DESCRIPTION provided by applicant Many patients requiring stem cell transplantation for hematological malignancies are unable to find a suitable HLA matched sibling or unrelated donor Transplants using stem cells from umbilical cord blood provide an alternative for these patients allowing transplantation to proceed with less stringent HLA matching requirements Unfortunately in addition to t ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Development of an Innovative Effective RNA based Vaccine for Chikungunya Virus

    SBC: PAI Life Sciences, Inc.            Topic: NIAID

    PROJECT SUMMARY ABSTRACT Chikungunya virus CHIKV is an emerging disease of global public health importance Originally identified in sporadic CHIKV outbreaks occurred in Africa and Asia for several decades Beginning with an outbreak on the island of La Reunion in the virus has continued to spread to new regions around the globe CHIKV is now endemic in the Caribbean is present in t ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. " Channel Multimodal Ultrathin Flexible SFE for cancer diagnosis and therapy"

    SBC: VERAVANTI INC.            Topic: 102

    Summary channel multimodal ultrathin flexible SFE for cancer diagnosis and therapy Minimally invasive optical imaging is being advanced by molecular probes that enhance contrast using fluorescence The applications in cancer imaging are very broad ranging from early diagnosis of cancer to the guiding of interventions such as surgery The high sensitivity afforded by wide field fluorescence i ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Optical visualization to efficiently guide coronary intervention of chronic total occlusions

    SBC: VERAVANTI INC.            Topic: NHLBI

    Summary Optical visualization to efficiently guide coronary intervention of chronic total occlusions We propose to investigate the use of the Scanning Fiber Endoscope SFE during coronary intervention for chronic total occlusions of the coronary arteries CTO CTOs represent the most challenging angioplasties and often have much higher failure rates compared with standard angioplasty Improved ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. A Phase Clinical Trial Evaluating the Novel Small Molecule Immuno Oncology Antagonist SX Alone and With Pembrolizumab in Metastatic Melanoma

    SBC: Syntrix Biosystems, Inc.            Topic: 102

    The chemokine receptors CXCR and CXCR CXCR are validated as having essential roles in the growth survival motility invasion and angiogenesis of human melanoma which secretes abundant amounts of the corresponding chemokine ligands including CXCL Additionally abnormal cancer induced immunosuppressive myeloid derived suppressor cells MDSCs in the circulation and tumor correlate with ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. CruziScreen a recombinant antigen based screening test for Chagas disease

    SBC: PAI Life Sciences, Inc.            Topic: NIAID

    Project Summary Chagas disease is a severe inflammatory syndrome caused by infection with a protozoan parasite Trypanosoma cruzi Although transmission occurs mostly through an intermediate insect host the infection is silent and chronic carriers pose a significant risk through the transfer of infected products made from donated blood of these individuals to blood recipients Up to new c ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Biocatalytic production of precursors to lutein and zeaxanthin to address age related macular degeneration

    SBC: EscaZyme Biochemicals, LLC            Topic: N

    Project Summary Atrophic dry age related macular degeneration AMD is the leading cause of severe loss of vision for those over age Dietary supplements containing lutein and zeaxanthin are recommended by the NEI for those at risk of late AMD There has been a corresponding growth in demand for these two xanthophylls Lutein and zeaxanthin are currently sourced from marigolds grown mostl ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. TRANSCRANIAL DOPPLER SIMULATOR FOR TRAINING AND ASSESSMENT

    SBC: Sheehan Medical LLC            Topic: 101

    We aim to develop a transcranial Doppler TCD ultrasound simulator on a physical mannequin for realistic medical training and professional competence testing The Specific Aims of the project are Develop a prototype TCD simulator The anatomy of the cerebrovascular system CVS will be reconstructed in three dimensional D from a patient s computed tomography angiogram CTA The blood flow ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health

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