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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Novel anti-viral agents to treat influenza

    SBC: ALEXANDER BIODISCOVERIES            Topic: NIAID

    DESCRIPTION provided by applicant Yearly influenza epidemics affect about of the worldandapos s population and estimates of annual mortality range from including approximately deaths and hospitalizations in the United States In addition the likelihood of a severe pandemic caused by a newly emergent strain of influenza virus is very high given that three such pandemics were recorded in the th centu ...

    SBIR Phase II 2013 Department of Health and Human ServicesNational Institutes of Health
  2. Distributed REMD Simulation for Probing Alzheimer Molecular Mechanisms

    SBC: PARABON COMPUTATION, INC.            Topic: NIA

    DESCRIPTION (provided by applicant): PUBLIC HEALTH RELEVANCE PUBLIC HEALTH RELEVANCE:

    STTR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health
  3. Biomarker discovery for immunodiagnosis of invasive candidiasis

    SBC: DxDiscovery Incorporated            Topic: NIAID

    DESCRIPTION (provided by applicant): Invasive candidiasis (IC) is one of the most serious threats to patients in a critical setting. With as many as 60,000 cases per year in the U.S., the total cost associated with IC in the U.S. may be as high as 2-4 billion/year. One of the most critical factors influencing patient outcome is early diagnosis. The goal of this project is a rapi and inexpensive i ...

    STTR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health
  4. Development of Novel LANCL2-based Anti-diabetic Compounds

    SBC: Biotherapeutics, Inc.            Topic: NIDDK

    DESCRIPTION (provided by applicant): About 28.3 million Americans have type II diabetes (T2D) and over 40.1% of middle-aged adults have prediabetes, a condition characterized by impaired glucose tolerance and insulin resistance. Current antidiabetic medications are effective in improving insulin sensitivity, but their chronic administration has significant side effects suc as cardiovascular compli ...

    STTR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health
  5. A Thermo-responsive Biopharmaceutical to Enhance the Tear Production of Lacritin

    SBC: EYERX RESEARCH, INC.            Topic: NEI

    Project Summary/Abstract Ocular pharmaceuticals predominantly use the topical route of administration, which involves a number of benefits and limitations when compared to systemic drug routes. A major limitation of the ocular topical route is the rapid loss of drug via tearing and nasolacrimal drainage, requiring the use of frequent dosing and high drug concentrations that then create formulation ...

    STTR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health
  6. Application of CDX-MDM in Pre-Clinical Model of Murine Pulmonary Emphysema

    SBC: Covenant Therapeutics LLC            Topic: NHLBI

    DESCRIPTION (provided by applicant): The objective of this proposal is to exploit a newly discovered anti-inflammatory function involving the aminopeptidase activity of the leukotriene A4 hydrolase for the treatment of pulmonary emphysema. The leukotrieneA4 hydrolase is a dual-functioning enzyme with dichotomously opposing functions. As an epoxide hydrolase, it catalyzes the conversion of leukotri ...

    STTR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health
  7. Interactive Technology for Hearing Aid Education and Acceptance

    SBC: Healthcare Technologies and Methods            Topic: NIA

    ABSTRACT More than 20 million elderly people in the US have significant hearing loss but only 20% use hearing aids. Of these, 35 - 50% are dissatisfied with them, which often results in the hearing aids being returned within the trial period or left in-the-drawer . With untreated hearing loss resulting in a 200% - 300% increase in the risk of dementia, depression, and falls, and severe communicat ...

    SBIR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health
  8. Establishing BRM Polymorphisms as Predictive Biomarkers for Lung Cancer Risk

    SBC: Rivanna Medical, LLC            Topic: NIAMS

    DESCRIPTION (provided by applicant): Despite being correlated to poor health outcomes, emergency department (ED) overcrowding occurs several times per week in 90% of all EDs in the US. A primary contributor to ED overcrowding is high demand for radiology services (i.e. X-rays), which are relied upon for diagnosis of bone fractures in 7.2 million non-time- sensitive suspected bone fracture patients ...

    SBIR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health
  9. VICTORY-Virtual Video Game Therapy for Substance Cessation and Recovery

    SBC: BARRON ASSOCIATES, INC.            Topic: NIDA

    DESCRIPTION (provided by applicant): Nicotine addiction poses a serious public health problem in the United States. Cigarette smoking alone has been identified as the cause of numerous diseases, including cancers (e.g., lung, bladder, kidney, and oral cancers, among others), cardiovascular diseases (e.g., atherosclerosis and coronary heart disease, among others), and respiratory diseases (e.g., pn ...

    SBIR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health
  10. Development of new anti-inflammatory peptides for treatment of type I diabetes

    SBC: SERPIN PHARMA, LLC            Topic: NIDDK

    DESCRIPTION (provided by applicant): Type I diabetes is an autoimmune disease where auto-immunity leads to slow, progressive destruction of pancreatic -cells and development of overt diabetes. Currently, there is no cure for type I diabetes, which is treated with insulin replacement therapy by daily injections. Immune modulation has the potential to arrest -cell destruction and several therapeu ...

    SBIR Phase I 2013 Department of Health and Human ServicesNational Institutes of Health
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