Award Data

DESCRIPTION provided by applicant Alcoholic Liver Disease ALD remains a leading cause of death from liver disease in the U S and no FDA approved therapy exists Abnormal cytokine metabolism is a major feature of ALD Elevated serum concentrations of tumor necrosis factor TNF and TNF inducible proinflammatory cytokines chemokines such as IL and IL have been reported in patients w ...

DESCRIPTION provided by applicant The basic functions of sleep are still unknown Abnormal sleep patterns can manifest as a variety of disorders sleep apnea parasomnias REM rapid eye movement sleep behavioral disorder RBD narcolepsy many of which are influenced by heredity There is an increasing focus on characterizing mouse behaviors for genetic and drug studies However discovering ...

DESCRIPTION provided by applicant The objective of this proposal is to demonstrate the feasibility of an innovative injection device proposed product to improve upon intratumoral delivery of liver therapeutics as compared to standard injection needles currently used Hepatocelluar carcinoma HCC will become an increasing burden on economic resources in the coming years as the prevalence of c ...

DESCRIPTION provided by applicant The population of the United States as in most developed nations is aging and is doing so at an increasing rate This change in demographics is having a dramatic effect on the nationandapos s healthcare delivery system and the related public costs The Congressional Budget Office predicts that the cost of long term care for the elderly will reach $ billion ...

DESCRIPTION provided by applicant The Emergency Responder Health Monitoring and Surveillance ERHMS Technical Assistance Document TAD aimed at National Response Teams highlights the need for a technology platform for collecting data before during and after disasters to assess the effect training has on response related illness and injury for emergency responders This SBIR grant applicati ...

DESCRIPTION provided by applicant Vector control remains the only means to combat many important mosquito borne pathogens including the viruses responsible for West Nile Dengue and Chikungunya A key deficiency of existing vector control methods is the inability to affect cryptic breeding sites which provide refugia to immature mosquitoes and allow for the rapid recovery of mosquito populations fol ...

DESCRIPTION provided by applicant Bipolar disorder BD is a complex chronic illness characterized by recurrent often dramatic mood changes Self management of BD is an important component of treatment but is likewise complex and can be fraught with difficulties including misunderstanding of the condition and a lack of self awareness Combined with the nationwide shortage of mental healthcare ...

DESCRIPTION provided by applicant The baculovirus expression vector system BEVS has been successfully utilized to produce thousands of proteins for use as vaccines and therapeutics as well as for studies of protein structure and function One limitation of BEVS is the propensity of baculoviruses to accumulate transposon insertions into the fp k gene leading to the andquot few polyhedra FP ...

DESCRIPTION provided by applicant Our goal is to develop a new molecular entity with a novel mechanism of action for targeting and eliminating glioblastoma multiforme GBM high grade glioma a deadly and invasive brain tumor with no effective treatment Of the patients expected to be diagnosed with GBM this year most will succumb within a year There is an urgent demand for an efficac ...

DESCRIPTION provided by applicant This proposal is in response to the mission of the Office of Research Infrastructure Programs ORIP to andquot Develop and provide access to critical animal models that offer essential clues to a broad range of human disordersandquot Our goal is to develop a universal animal model that best recapitulates non healing human chronic wounds The burden of chroni ...