Award Data

Project Summary The broad goal of this project is the pharmacological validation of GIV a nonreceptor guanine nucleotide exchange factor GEF for liver fibrosis GIV sits at the hub of profibrogenic signaling in liver fibrosis and is required for the key physiological events that lead to this condition the migration proliferation and extracellular matrix deposition of hepatic stellate cells ...

Tinea capitis scalp ringworm is a fungal dermatophyte infection of scalp hair follicles that afflicts of the U S pediatric population Tinea capitis is a major health care disparity because it occurs predominantly among individuals with a disadvantaged socioeconomic background and sub Saharan African descent Diagnosis of tinea capitis is currently dependent on culture and microscopy Both ...

Abstract We will develop a fluorescence image guided surgery FIGS system that delivers optimum background free performance without the need to turn off or lower room lighting Fluorescence image guided surgery FIGS is a rapidly evolving field with broad clinical applications including more efficacious removal of tumors in real time however ambient room lighting contaminates the fluorescen ...

Project Summary Abstract Cardiovascular drugs are primarily prescribed to older peoplertyears of agesince the prevalence of chronic heart failure and fibrillation increases with ageThe incidence of other diseasesincluding cancer and neurological disordersincreases with agetooAny medications hold potential risks to cause adverse eventsThereforethe risks of medications in older people also increase ...

Project Summary Abstract Rush River Research RRR Corporation proposes to develop and commercialize a novel passive exoskeleton that helps young children with very little residual strength to use their arms The proposed orthosis could help the over children with many different neuromuscular disorders including muscular dystrophy spinal muscular atrophy cerebral palsy arthrogryposis mu ...

Project Summary Abstract Amyotrophic lateral sclerosis ALS also known as Lou Gehrig s disease is a devastating neurological disorder with patients typically surviving just three to five years after diagnosis Approximately Americans live with ALS and another are diagnosed each year ALS Association Despite identification of over candidate drugs from studies with model animal ...

Swallowing disorders known as dysphagia are associated with increased mortality and morbidity including malnutrition dehydration pulmonary complications and reduced quality of life More than M adults and millions more children suffer from dysphagia This disorder commonly causes liquids whether overly thin water coffee or overly thickened to be aspirated or misdirected into the air ...

Project Summary Abstract High throughput screening HTS is a powerful method for the discovery of new drug leads for target enzymes In HTS assays the activity of the target enzyme is often evaluated by quantifying a small molecule or cofactor that is produced or consumed by the enzyme While antibodies are a mainstay of small molecule detection as says they do have severe limitations which a ...

Abstract In humans and animals G protein coupled receptors GPCRs are embedded on cell surfaces and function as key regulators of physiological events by transmitting signals from extracellular stimulants across the cell membrane into the cell Impaired or abnormal GPCR function can result in disordered physiological processes causing a broad and diverse range of diseases For this reason GPCRs ...

Project Summary Abstract Neurological and psychiatric disorders including substance abuse and addiction exert a devastating personal and economic toll on patients families caregivers and society This is in part due to our failures in developing effective medications which in turn to the drug discovery platforms that are often not relevant to target diseases Recent development of induced p ...