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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. HLS Potent novel inhibitor of fibrinolytic hemorrhage

    SBC: Translational Sciences Inc.            Topic: NHLBI

    This SBIR Application is responsive to NHLBI Small Business Topics of Special Interest therapeutics that are of high programmatic interest HL Hemorrhage or bleeding is a serious or fatal complication of surgery Antifibrinolytic agents that inhibit plasmin mediated fibrinolysis can significantly reduce blood loss emergency reoperation morbidity and death in patients with severe hemor ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Enabling point of care molecular diagnostics by developing an adaptive PCR instrument and on demand kit reagents

    SBC: BIOVENTURES, INC            Topic: 172

    Because of its high sensitivity polymerase chain reaction PCR is the gold standard for the diagnosis of many infectious diseases but generally only implemented in well equipped laboratories One of the major roadblocks for expanding PCR to point of care markets is the lack of simple robust single tube PCR designs which preserve its laboratory based high sensitivity and specificity In this F ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Long non coding RNA signatures to distinguish fibromyalgia syndrome from rheumatic diseases

    SBC: IQUITY LABS, INC.            Topic: NIAID

    No other group of diseases encompasses a greater pathophysiology than do the rheumatic diseases Spanning multiple organ systems clinical decisions often rely on coordinated efforts from primary care providers and rheumatologists to rule in or rule out differential diagnoses when treating inflammatory conditions such as rheumatoid arthritis RA and systemic lupus erythematosus SLE RA is a sym ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Development of Tumor Proliferation PET Tracer FLT using a Low Cost Single Dose Automatic Production and Quality Control Biomarker Generator System

    SBC: ABT Molecular Imaging            Topic: 102

    DESCRIPTION provided by applicant Worldwide a person dies from cancer every seconds Positron emission tomography PET is an effective tool that is critical in diagnosing cancer and monitoring treatment efficacy PET imaging relies on use of short lived radioisotopes Commercial distribution of the most commonly used radio tracer F FDG has resulted in patient population coverage in ...

    SBIR Phase II 2016 Department of Health and Human ServicesNational Institutes of Health
  5. Development of a Non adjuvanted VLP Vaccine against Stealth H N Influenza

    SBC: EPIVAX, INC.            Topic: NIAID

    DESCRIPTION provided by applicant The avian origin H N influenza virus that emerged in humans in China in presents a unique challenge to vaccine development because it is poorly immunogenic Neutralizing antibodies are not detected in acute phase infection Anti H antibody responses are significantly delayed and exhibit low avidity in comparison with antibodies generated following seas ...

    SBIR Phase I 2016 Department of Health and Human ServicesNational Institutes of Health
  6. The anti-diarrheal potential of a LPA analog Rx100

    SBC: RxBio, Inc.            Topic: 300

    DESCRIPTION provided by applicant Secretory diarrhea is a leading cause of death worldwide among children under the age of five Its pathology involves cystic fibrosis transmembrane conductance regulator CFTR which provides a primary pathway for Cl secretion Targeting CFTR to prevent reduce losses of electrolytes and water is a therapeutic strategy Lysophosphatidic acid LPA a naturally o ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  7. Expanding the throughput of real-time toxicological screening of cardiac differentiation by expressing a synthetic luciferase/luciferin genetic pathway in iPSCs

    SBC: 490 BIOTECH INC            Topic: NIEHS

    DESCRIPTION provided by applicant Expanding the throughput of real time toxicological screening of cardiac differentiation by expressing a synthetic luciferase luciferin genetic pathway in iPSCs Project Summary This Small Business Innovation Research SBIR Phase I project proposes to develop autonomously bioluminescent induced pluripotent stem cells iPSCs for continuous reagent free and ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  8. Latinos Kick Buts: Mobile Engagement and Cessation Support for Latino Smokers

    SBC: AGILE HEALTH INC            Topic: NIMHD

    DESCRIPTION provided by applicant Latinos Kick Buts Mobile Engagement and Cessation Support for Latino Smokers Latinos are less likely than non Hispanic whites to have access to health to have knowledge of existing smoking cessation resources to receive advice to stop smoking and to participate in smoking cessation programs Mobile technologies can dramatically enhance the reach of effectiv ...

    STTR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health
  9. Novel Methods for Dissolving Blood Clots

    SBC: Translational Sciences Inc.            Topic: NHLBI

    DESCRIPTION provided by applicant Each year venous thromboembolism VTE affects up to million Americans and million people worldwide VTE patients have blood clots in the legs venous thrombosis that may travel to the lungs pulmonary embolism Up to of VTE patients die and the annual direct U S healthcare costs are $ billion For more than years anticoagulation has been ...

    SBIR Phase II 2015 Department of Health and Human ServicesNational Institutes of Health
  10. TransilienceHD: A Healthcare Professional Platform for the Elimination of Prostate Cancer Disparities

    SBC: Q-Leap Health Incorporated            Topic: NIMHD

    DESCRIPTION provided by applicant The goals of eliminating prostate cancer PCa disparities remain elusive PCa is the most common cancer in American men African American men have a higher incidence than Caucasian American men and their death rates are times that of Caucasian and American Indians and times that of Asian or Pacific Islanders Transformative technologies like social ...

    SBIR Phase I 2015 Department of Health and Human ServicesNational Institutes of Health

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