Award Data

The broader impact of this Small Business Innovation Research (SBIR) Phase I project is the potential reduction of toxic nitrogen oxides (NOx) and harmful carbon dioxide (CO2) emissions from marine diesel engines. There are approximately 4 million diesel-powered craft in use globally, emitting approximately one billion tons of CO2 and 100 million tons of NOx annually. This project seeks to remove ...

The SolarSurveillance project addresses security and reliability issues of string inverters in solar photovoltaic systems. Existing intrusion detection systems have limitations, hindering their effectiveness in detecting potential cyber threats and system failures. The project aims to develop an effective and adaptive intrusion detection system for string inverters, contributing to the development ...

Subsurface resources present a tremendous opportunity not only for extraction of oil and gas, but also geothermal resources as well as a reservoir for sequestration of carbon and other wastes. When last studied, experts concluded that as much as 200,000 exojoules of untapped energy is available in enhanced geothermal system (EGS) resources: 2,000 times the annual consumption of primary energy cons ...

Annular extruded plastics are in everything from fuel lines, hoses, pipes, and wires to catheters, medical tubing, and stents and makes up about ? of the $200B extruded plastics market. Extrusion manufacturing is a major processor of the $600B raw plastics industry, which produces 380 million metric tons of material each year. The production of these materials accounts for 4% of oil consumption an ...

Perfluoroalkyl and Polyfluoroalkyl Substances (PFAS) the toxic "forever chemicals" that do notbreak down naturally can be found in sewage sludge and biosolids commonly used as fertilizers.PFAS is an umbrella term for any of the 9000 PFAS compounds known to date currently there areno federal regulations on PFAS compounds. The PFAS contaminants concentrate in feed crops andwater supply which is then ...

An excellent process to generate a biobased product with little environmental impact is to breakdown a single-use product like plastics into its monomers and reuse those monomers to recreatethe original product. If non-biodegradable plastics could be reused as high-quality plastics positiveimpacts on the environment could be realized. Polyethylene terephthalate (PET) is accumulating inthe environm ...

Project Summary/Abstract Bone marrow aspirates are critical to the diagnosis, staging, and monitoring of hematologic conditions and cancers (e.g., leukemia, aplastic anemia, sickle cell disease, and metastasis of solid tumors), but 8-50% of aspirations are unsuccessful due to operator technique, hemodilution, or underlying pathology. Because this process is manual and error-prone, there is an oppo ...

ABSTRACT The identification and removal of process-related protein impurities (PRPI) from biologic products is a critical step in drug development. Despite recent improvements in the purification and processing of biologics, the presence of immunogenic PRPI continue to raise concerns about drug safety and efficacy. We propose an innovative approach for assessing immunogenicity risk of PRPI using o ...

Project SummaryThe overall goal of this SBIR project is to establish the technical feasibility for commercialization of a patent-pending sample preparation technology that concentrates and recovers microbial contaminants from appropriately scaled water samples. The proposed product is affordable, versatile, reusable, portable, and automated device with no moving parts, suitable for on-site or in-f ...

Project Summary/Abstract Evaluation for neutropenia and/or thrombocytopenia requires a 5-part white blood cell (WBC) differential with platelet count. Currently, instruments capable of these measurements must be operated in a CLIA-certified laboratory and rely on complex workflows involving multiple reagents, extensive calibration and maintenance, and operation by highly trained personnel. Turnaro ...