Award Data

DESCRIPTION (Scanned from the Applicant's Abstract): Blockade of A2B adenosine receptors (A2BARs) increases insulin sensitivity in insulin resistant obese Zucker rats by an effect on skeletal muscle. We have synthesized and characterized the first potent and selective antagonists of A2B receptors. The goal of this phase I SBIR proposal is to develop improved A2 ...

DESCRIPTION: (Adapted from the Investigator's Abstract): Adenosine administered as an aerosol to asthmatics causes bronchoconstriction, while in non-asthmatics adenosine causes bronchodilation. This occurs because the activation of A2B adenosine receptors on sensitized mast cells triggers degranulation, releasing histamine, leukotrienes, and other allergic mediators. A2B a ...

The purpose of this research is to develop and test the feasibility of a novel portable computerized system that will enable nursing assistants to provide improved patient care. The system will enable nursing assistants to work more efficiently, record data more accurately, and spend more time with each patient. The system is being designed for use in assisted living facilities and nursing home ...

The intelligence community is hampered in its ability to provide information to a gamut of users. The critical shortfalls are database access, timely data fusion, robust dissemination techniques, and communications bandwidth. This effort will create adynamic and responsive intelligence architecture to include; multiple database access, support dynamic user profiling through intelligent agents, p ...

The intelligence community is hampered in its ability to provide information to a gamut of users. The critical shortfalls are database access, timely data fusion, robust dissemination techniques, and communications bandwidth. This effort will create adynamic and responsive intelligence architecture to include; multiple database access, support dynamic user profiling through intelligent agents, p ...

The proposed Phase II program will optimize the design and manufacturing process of a compliant brush shroud casing. Recent tests at Wright Laboratories with staged brush seals have demonstrated significantly increased blade to shroud rub tolerance of acompliant casing. Phase I of the program is expected to demonstrate the feasibility of two innovative brush shroud designs with lower cost and we ...

The proposed Phase II program will optimize the design and manufacturing process of a compliant brush shroud casing. Recent tests at Wright Laboratories with staged brush seals have demonstrated significantly increased blade to shroud rub tolerance of acompliant casing. Phase I of the program is expected to demonstrate the feasibility of two innovative brush shroud designs with lower cost and we ...

Future satellite architectures must readily support the on-orbit maintenance and servicing that is vital for maintaining and dynamically reconfiguring both commercial and military satellites during orbital operation. A well-founded architectural designmust also address the need to reduce costs associated with satellite development, fabrication, and operation; improve flexibility in response to mis ...

The ability to maneuver, change orbits, and rapidly deploy spacecraft is a key requirement for the space user community. However, large and bulky propulsion systems with a significant mass of fuel on board often limit the maneuverability and capabilitiesof space vehicles. AeroAstro is developing aerobraking concepts and structures that use the Earth's atmosphere for braking and steering, signifi ...

Stochastic resonance (SR) is a counterintuitive phenomenon in which slight amounts of noise imparted to a system actually increase its sensitivity to weak stimuli. SR has been shown to produce a demonstrable effect in human sensory cells. In both healthy young and clinical subjects - elderly, diabetics, and stroke sufferers - a notable increase in tactile and proprioceptive sensitivity is seen whe ...