Award Data

DESCRIPTION (provided by applicant): Cancer is one of the major causes of death in the U.S. and many developed countries with an estimated economic burden of over 100 billion dollars in direct and indirect costs in the U.S. alone. Although surgery, chemotherapy, and radiotherapy are commonly used treatment modalities, these therapies not only fail to effectively manage cancer, but also are associ ...

75336S A broad category of experiments in astro-particle and high energy physics requires the construction of ultra-high-purity and ultra-low-radioactive-background, cubic-meter-scale vessels to be used as containers for ionization and scintillation media. Double-beta decay experiments, solar neutrino experiments, and dark matter searches would all benefit from this technology. Plastics are amo ...

Applied Radar Inc. proposes the development of active MMIC-based circulators in order to achieve high isolation between transmit and receive paths for simultaneous transmit and receive (STAR) phased-array radar system architectures. This technology will enable increased persistence in intelligence, surveillance and reconnaissance (ISR) systems and allow multiple simultaneous radar modes including ...

Applied Radar proposes to investigate a new method of incorporating microwave antenna and feed components directly into airframe structural members. This method is based on the 3-D weaving of a resin transfer molded (RTM) fiber reinforcement preform that meets both RF and structural requirements. The result will be lighter weight, higher performance radar and communications antenna arrays for both ...

The Defense Threat Reduction Agency has expressed the need for waterborne transport and dispersion capability to compliment its existing models for Chemical, Biological, Radiological and Nuclear (CBRN) releases. DTRA's current capability is limited to the atmospheric transport of CBRN agents using the HPAC system. The objective of this proposed Phase I study is to couple Applied Science Associat ...

DESCRIPTION (provided by applicant): Individuals with epilepsy, their families and the professionals that treat them have long felt the need for reliable warning of an impending epileptic seizure. In Phase I, we developed a unique, multi-parameter, individualized, trainable seizure predetection system which extracts spectral, wavelet and time domain features and uses recurrent neural networks to ...

This project is the development of a single crystal underwater acoustic modem transducer for Unmanned Underwater Vehicles (UUV) which is compact in size, operates at low to moderately low center frequencies, in a broad band frequency range to accommodate state-of-the-art binary, FSK and spread spectrum signaling schemes that promote covertness. The device exploits the high coupling coefficient an ...

DESCRIPTION (provided by applicant): This project proposes to develop a device that will improve the quality and availability of motor retraining for individuals with neuromotor disorders due to stroke or incomplete spinal cord injury. Biofeedback of postural control variables such as ground reaction force and center of pressure sway has been used effectively, however, existing devices are not sui ...

DESCRIPTION (provided by applicant): The purpose of this proposal is to provide proof-of-concept that a novel therapy that prevents complement activation could be effective in reducing ischemia reperfusion injury (IRI) in transplanted organs. Complement activation after IRI in transplanted organs is a well-known phenomenon that may be responsible for delayed graft function and the hastening of ...

DESCRIPTION (provided by applicant): EpiVax discovers and develops epitqpe-driven vaccines by screening microbial genomes for protective epitopes. In this application, we describe a genome-based approach for the development of a therapeutic vaccine against Helicobacter pylori disease. First, the H. pylori genome will be scanned for immunodominant Th epitopes by computer-driven (EpiMatrix) analysi ...