Award Data

This Small Business Innovation Research (SBIR) Phase I project focuses on the development of techniques that will facilitate the design and development of affordable, compact, and patient-friendly magnetic resonance imaging (MRI) systems. MRI systems are the preferred modality for a range of imaging types, notably pediatrics, due to their superior diagnostic capabilities, high resolution, and mini ...

The broader impact of this Small Business Innovation Research (SBIR) Phase II project is the development of a commercially-ready cell engineering platform that will enable a curative therapy for cancer in the veterinary market.An estimated 250,000 dogs get B cell lymphoma every year. Chimeric Antigen Receptor (CAR)-T cell therapy offers hope for a treatment for this disease. The project platform f ...

Commercial buildings use 35% of the entire US energy output, and up to a third of that energy is wasted. Rapidly rising fuel costs, increasing concern about climate change, and policy directives from the Biden Administration are all driving the need for increased energy efficiency and the elimination of waste. At the same time, the COVID-19 pandemic has dramatically increased public awareness of t ...

Project Summary/Abstract Alzheimer’s disease (AD) affects more than six million Americans currently and is projected to affect 14 million at a cost of $1.2 trillion in 2050. Despite its tremendous impacts and the limited influence of pharmacological therapies, attention has been brought to non-pharmacological interventions as promising therapeutic strategies for the prevention of cognitive decli ...

Project Summary / Abstract More than 2 million people in the United States have an Opioid Use Disorder (OUD). Overall, at least half of the treatment-seeking population relapse, contributing to over 75,000 overdose deaths annually. The purpose of this SBIR Fast-Track application is to create a regulated device to objectively monitor Cue-Induced Craving (CIC) in Opioid Use Disorder (OUD) patients. ...

Project Summary/Abstract The proposed project relates to the development of a novel passive automated screening approach for identifying fall risk in the elderly. Falls are the leading cause of both fatal and non-fatal injuries among adults age 65 and older and the risk of fall-related death among older adults is increasing. Annually, 28.7% of older adults fall in the United States, resulting in 3 ...

Project Summary/Abstract Older adults are disproportionately affected by falls. Older adults who have memory loss (mild to moderate cognitive impairment) can forget to wear wireless alert pendants or wristbands that are used in case they fall in their home. Falls among adults 65 and older caused over 34,000 deaths in 2019, making it the leading cause of injury death for that group. Older adult fal ...

PROJECT SUMMARY/ABSTRACT This proposal will improve the care of patients suffering from Acute Ischemic stroke (AIS). Catheter-based thrombectomy has been established as the standard treatment for AIS. Still, substantial limitations remain: lt50% of patients achieve first-pass clot clearance, the best predictor of good neurological outcome, largely due to shortcomings in the approach (transfemoral ...

PROJECT SUMMARY Duchenne muscular dystrophy (DMD) is the most common type of muscular dystrophy, caused due to mutations in the dystrophin gene. DMD is characterized by progressive muscle wasting and overall loss of muscle function. DMD patients become wheel chair dependant by 12 years of age and the associated cardiorespiratory complications result in their early death around 20 years of age. Dys ...

Necrotizing enterocolitis (NEC) is a devastating acute inflammatory condition of the gastrointestinal tract resulting in intestinal necrosis, systemic sepsis and multi-system organ failure found mostly in infants born prematurely. Despite modern medical advances in the past decade, the etiology remains elusive and morbidity and mortality are still unacceptably high. It has been concluded that the ...