Award Data

DESCRIPTION provided by applicant There is societal need for new therapeutic agents in our arsenal of defenses against bacterial and fungal pathogens many of which are increasingly resistant to existing antibiotics Filamentous fungi are considered promising resources for the development of novel bioactive compounds because of their great potential to produce various kinds of secondary metabol ...

DESCRIPTION provided by applicant Air quality affects the health and well being of each of us especially those with chronic respiratory diseases Acute exposure to fatal levels of hazard materials causes millions of accidents every year and unnoticed long term exposure to lower levels of chemicals affect far more people Various technologies have been developed to monitor air quality but no ...

DESCRIPTION provided by applicant Microarray technology has dramatically advanced the study of protein interactions leading to discovery and validation of new biomarkers and therapeutic drugs Typically protein microarrays are pre spotted with target molecules in one device and then tested with probe molecules using another device During each testing cycle the entire microarray becomes expos ...

DESCRIPTION provided by applicant Glioblastoma multiforme GBM or andquot glioblastoma andquot is the most common and aggressive malignant primary brain tumor in humans An effective treatment that increases patient survival would represent a significant advance in the field and provide a desperately needed new therapy for this deadly disease EnduRx is focused on the development of new tar ...

DESCRIPTION provided by applicant Storage and maintenance of valuable genotypes of animal model species as live animal lines would be wholly impractical However traditional cryopreservation techniques will be soon found to be inefficient for providing economic approach for cryopreservation of cells and tissues from millions of new animal models being developed Efficient cryopreservation of c ...

DESCRIPTION provided by applicant The goal of this project is to provide a synthetic biomaterial capable of giving long term repair of full thickness chondral lesions with the aim of helping to reduce the joint replacements carried out each year in the USA Our company has developed a synthetic biomaterial technology with proven biocompatibility in treating over patients for bon ...

DESCRIPTION provided by applicant Cell membrane capacitance is directly proportional to cell surface area This is true because membrane composition thickness and dielectric constant are invariant and not changed by differences in membrane protein density It is thus possible to monitor cellular capacitance fluctuations as a measure of cell surface area changes that occur with exo and endo c ...

DESCRIPTION provided by applicant Cells secrete hormones and neurotransmitter via exocytosis Understanding how exocytosis is regulated and how pharmaceuticals and toxins inhibit exocytosis is of broad medical significance because it aids in developing approaches to treat medical conditions where release of transmitter needs to be enhanced e g Parkinsonandapos s disease or inhibited e g ...

DESCRIPTION provided by applicant Long term objectives Modified ribonucleic acids RNA are important regulators of numerous cellular processes and are increasingly being associated with human diseases For example non coding microRNAs play significant roles in neuronal development and can serve as biomarkers for psychiatric disorders Another such modified RNA is circular RNA circRNA a ...

DESCRIPTION provided by applicant Colorectal cancer CRC is the second most common cause of cancer death in the US causing more than deaths each year Unfortunately African Americans AAs experience disproportionate incidence and mortality rates of CRC across all races in the US due to a complex interplay of economic social and cultural factors AAandapos s higher incidence lower r ...