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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Rapid automated polarizable multipole-based force field parameterization for accurate drug-receptor binding affinity calculations.

    SBC: DRUG DESIGN METHODOLOGIES, L.L.C.            Topic: 500

    PROJECT SUMMARY ABSTRACTDrug Design MethodologiesChris HoM DPh DThis SBIR will develop automated software to accurately estimate drug target binding affinity and selectivityThis capability is crucial to drug discoveryyet remains elusive in all current design toolsOur technology identifies favorable candidates and distinguishes problematic ones that could exhibit side effects due to weak or non sel ...

    SBIR Phase I 2018 Department of Health and Human Services
  2. Glycoengineering a bioconjugate vaccine against Klebsiella pneumoniae

    SBC: VaxNewMO            Topic: NIAID

    PROJECT SUMMARY Klebsiella pneumoniae is an increasingly prevalent drug resistant nosocomial pathogenCommonlyKpneumoniae isolates are carbapenem resistantwhich are referred to as carbapenem resistant EnterobacteriaceaeCREand present significantly less therapeutic intervention optionsFurthermorecommunity acquired infections associated with hypervirulent isolates of Kpneumoniae have emerged that are ...

    STTR Phase I 2018 Department of Health and Human Services
  3. A Novel Inhibitor of the Classical Pathway of Complement

    SBC: AnthroBio, Inc.            Topic: NHLBI

    A novel inhibitor of the classical pathway of the complement system Abstract The classical pathway of the complement system is implicated in the pathogenesis of a number of human autoimmune diseasesincluding systemic lupus erythematosusrheumatoid arthritisalloantibody mediated transplant rejection and autoimmune hemolytic anemiaDespite a large body of literature documenting the role of the complem ...

    SBIR Phase I 2018 Department of Health and Human Services
  4. Minimizing bloodstream infection detection time using laser light-scattering

    SBC: BacterioScan            Topic: NIAID

    PROJECT SUMMARY Bloodstream infectionsBSIsrepresent a very serious clinical manifestation that can be caused by a variety of bacterial and fungal pathogensmany of which have been associated with high rates of mortalityPhysicians caring for patients with BSIs are challenged with having very limited time to make an effective diagnosisincluding identification of the causative agent and determination ...

    SBIR Phase I 2018 Department of Health and Human Services
  5. Using Augmented Reality To Make Cardiac Ablation Procedures Simpler and Safer

    SBC: SENTIAR, INC.            Topic: NHLBI

    Abstract The goal of this SBIR FastTrack application is to deliver an augmented realityARplatform technology that displays an interactiveD cardiac hologram to make ablation procedures simpler and saferWorld widecardiac ablations are used as therapy formillion arrhythmia patients every yearThere ishoweversignificant skill required to perform these procedures and only a handful of cases can be perfo ...

    SBIR Phase I 2018 Department of Health and Human Services
  6. Synergistic Anti-tumor Efficacy of an Interleukin 2 Analog and PD-1 blockade

    SBC: APT THERAPEUTICS, INC.            Topic: 102

    Principal Investigator Program DirectorLastFirstMiddleChenRidong Abstract The durable clinical efficacy of immune checkpoint inhibitors in a variety of cancers has demonstrated the tremendous potential of tumor immunotherapyHowevercurrent approaches are limited to immunogenic tumors that acquire adaptive resistanceInterleukinILimmunotherapy can result in remarkable long term responses in some canc ...

    SBIR Phase I 2018 Department of Health and Human Services
  7. Immunomodulatory Therapy for Neuropathic Pain

    SBC: APT THERAPEUTICS, INC.            Topic: 101

    Principal Investigator Program DirectorLastFirstMiddleRidong Chen Project SummaryNeuropathic pain can be difficult to treat with onlyof patients achieving meaningfulandgtpain reliefCurrent therapiese ggabapentinmainly address symptoms by focusing on blocking neurotransmission in the pain pathway with limited efficacypotentially severe side effects and narrow therapeutic indexThusnovel therapies ar ...

    SBIR Phase I 2018 Department of Health and Human Services
  8. Robust and Fast Taq Mutants Designed for Direct and Rapid Point of Care Tests

    SBC: DNA POLYMERASE TECHNOLOGY, INC.            Topic: 400

    Problems and limitations in PCR based clinical tests can be related to specificitysensitivityspeedand presence of inhibitorsOur purpose is to provide point of carePOCdevise makersdiagnostic companiesand researchers with novelspecially engineered DNA polymerases to meet the increasing need for reliablefastand highly specific PCRwhich in addition can tolerate various PCR inhibitorsSuch polymerases a ...

    SBIR Phase I 2018 Department of Health and Human Services
  9. Plasma Abeta isoform concentrations in cognitively impaired patients at risk for amyloidosis

    SBC: C2N DIAGNOSTICS, LLC            Topic: NIA

    PROJECT SUMMARY ABSTRACT For a long timethe study of Alzheimer s diseaseADin humans has been hampered by the fact that absolute AD diagnosis could only be ascertained by assessment of brain pathology upon autopsyMore recentlyimaging agents have become available that allow direct imaging of the two hallmarks of ADamyloid plaques and tau tanglesin living humansHoweverthese imaging agents are expensi ...

    SBIR Phase I 2018 Department of Health and Human Services
  10. Stage-Based Mobile Intervention for Substance Use Disorders in Primary Care: Implementation and Cluster-Randomized Trial

    SBC: Pro-Change Behavior Systems Inc            Topic: NIDA

    Nearlymillion Americans ageand olderneed treatment for a substance use disorderSUDWhile onlyof individuals requiring treatment for a SUD receive itan estimated two thirds see a primary care or urgent care provider everymonthsPrimary care providers are in a unique position to perform ScreeningBrief Interventionand Referral to TreatmentSBIRTWith Phase I contract fundingPro Change developed and pilot ...

    SBIR Phase I 2018 Department of Health and Human Services

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