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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. CSAT: A User-friendly Efficient NIST-spec Information System Development Guideline Tool

    SBC: INFOBEYOND TECHNOLOGY, LLC            Topic: None

    NIST developed risk management framework and guidelines that assist agencies to implement integrated, organization‐wide programs to manage information security risk, and further developed Cloud Security Architecture Tool (CSAT) to facilitate in this matter. However, NIST’s CSAT needs further improvement and implementation of new functions such that it can be commercialized as an Enterprise‐g ...

    SBIR Phase II 2019 Department of CommerceNational Institute of Standards and Technology
  2. Commercialization of a Rapid Blood Test for Traumatic Brain Injury

    SBC: Fawkes Biotechnology, LLC            Topic: 100

    Traumatic brain injuryTBIis a substantial health care issue affecting both civilian and military populationsAlthough extremes of head injury are recognizablemild to moderate TBImmTBIis more difficult to diagnose leading to a need for the identification of circulating biomarkers of brain injury that may facilitate early identificationUsing a rat model of TBI we identified a novel marker of neuronal ...

    STTR Phase I 2018 Department of Health and Human Services
  3. Rapid automated polarizable multipole-based force field parameterization for accurate drug-receptor binding affinity calculations.

    SBC: DRUG DESIGN METHODOLOGIES, L.L.C.            Topic: 500

    PROJECT SUMMARY ABSTRACTDrug Design MethodologiesChris HoM DPh DThis SBIR will develop automated software to accurately estimate drug target binding affinity and selectivityThis capability is crucial to drug discoveryyet remains elusive in all current design toolsOur technology identifies favorable candidates and distinguishes problematic ones that could exhibit side effects due to weak or non sel ...

    SBIR Phase I 2018 Department of Health and Human Services
  4. Glycoengineering a bioconjugate vaccine against Klebsiella pneumoniae

    SBC: VaxNewMO            Topic: NIAID

    PROJECT SUMMARY Klebsiella pneumoniae is an increasingly prevalent drug resistant nosocomial pathogenCommonlyKpneumoniae isolates are carbapenem resistantwhich are referred to as carbapenem resistant EnterobacteriaceaeCREand present significantly less therapeutic intervention optionsFurthermorecommunity acquired infections associated with hypervirulent isolates of Kpneumoniae have emerged that are ...

    STTR Phase I 2018 Department of Health and Human Services
  5. PLGA encapsulated polyphenols to ameliorate IBD.

    SBC: THERAPYX, INC.            Topic: R

    Abstract Green tea has received increased attention recentlydue to several epidemiological and clinical studies showing a positive relationship between consumption and disease preventionBenefits include reduced risk of cardiovascular diseasese gmyocardial infarctionhypertensionatherosclerosisneurodegenerative diseasese gParkinson s and Alzheimer s diseaseand certain cancerse ggastricbreast and cer ...

    SBIR Phase I 2018 Department of Health and Human Services
  6. Exploiting activation-induced cell death as a means of inducing tolerance to kidney allografts

    SBC: FasCure Therapeutics LLC            Topic: NIAID

    PROJECT SUMMARY Kidney transplantation is the preferred treatment for patients with end stage renal diseaseHoweverstandard immunosuppression to control rejection is the major limitationAlthough standard immunosuppression has gradually been improved for better efficacy and safetyit still carries a great risk for adverse effects ranging from malignancies and infections to cardiovascular complication ...

    SBIR Phase I 2018 Department of Health and Human Services
  7. A Novel Inhibitor of the Classical Pathway of Complement

    SBC: AnthroBio, Inc.            Topic: NHLBI

    A novel inhibitor of the classical pathway of the complement system Abstract The classical pathway of the complement system is implicated in the pathogenesis of a number of human autoimmune diseasesincluding systemic lupus erythematosusrheumatoid arthritisalloantibody mediated transplant rejection and autoimmune hemolytic anemiaDespite a large body of literature documenting the role of the complem ...

    SBIR Phase I 2018 Department of Health and Human Services
  8. Minimizing bloodstream infection detection time using laser light-scattering

    SBC: BacterioScan            Topic: NIAID

    PROJECT SUMMARY Bloodstream infectionsBSIsrepresent a very serious clinical manifestation that can be caused by a variety of bacterial and fungal pathogensmany of which have been associated with high rates of mortalityPhysicians caring for patients with BSIs are challenged with having very limited time to make an effective diagnosisincluding identification of the causative agent and determination ...

    SBIR Phase I 2018 Department of Health and Human Services
  9. mHealth for Patient Self-Management of Opioid Use Disorder

    SBC: Biomedical Development Corporation            Topic: 104

    Opioid abuse has become an epidemic with devastating healthsocialand economic consequences for the United StatesDrug overdose deaths have nearly tripled fromDuringdrug overdoses accounted forU Sdeathsincludingthat involved an opioidopioid pain relievers and heroinOpioid analgesic overdose is now the leading cause of injury death in the U Sinthere were approximately one and a half times more drug o ...

    SBIR Phase I 2018 Department of Health and Human Services
  10. Using Augmented Reality To Make Cardiac Ablation Procedures Simpler and Safer

    SBC: SENTIAR, INC.            Topic: NHLBI

    Abstract The goal of this SBIR FastTrack application is to deliver an augmented realityARplatform technology that displays an interactiveD cardiac hologram to make ablation procedures simpler and saferWorld widecardiac ablations are used as therapy formillion arrhythmia patients every yearThere ishoweversignificant skill required to perform these procedures and only a handful of cases can be perfo ...

    SBIR Phase I 2018 Department of Health and Human Services

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