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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. UNIQUE IMMUNOASSAYS FOR DETECTION OF CIGUATOXIN AND RELATED MARINE TOXINS USING MONOCLONAL ANTIBODIES

    SBC: Moana Bioproducts Inc            Topic: N/A

    THIS PROPOSAL DESCRIBES A UNIQUE AND HIGHLY SIMPLIFIED IMMUNOLOGICAL PROCEDURE USING A MONOCLONAL ANTIBODY TO CIGUATOXIN IN A TWO-STEP PROCEDURE. THE MONOCLONAL ANTIBODY(MAB) IS PREPARED BY THE MOUSE HYBRIDOMA TECHNIQUE, USING HIGHLY PURIFIED CIGUATOXIN CONJUGATED TO PROTEIN CARRIERS. THE MAB-CTX THUS OBTAINED IS CONJUGATED TO COLLOIDAL GOLD (< 0.45 UM DIAMETER) OR COLORED LATEX PARTICLES. THIS WI ...

    SBIR Phase I 1989 Department of Commerce
  2. ORGANIC PHASE IMMUNOCHEMISTRY

    SBC: Hawaii Biotech, Inc.            Topic: N/A

    IMMUNOCHEMICAL TECHNIQUES HAVE MANY DIVERSE APPLICATIONS. HOWEVER, THEY ARE RESTRICTED TO USE ONLY IN AQUEOUS MEDIA. ECONOMICAL TECHNIQUES FOR DIRECT ORGANIC PHASE ANALYSIS AND IMMUNOAFFINITY ISOLATION WOULD SIGNIFICANTLY BROADEN THE USEFULNESS OF ANTIBODY-BASED TECHNOLOGY. THE PURPOSE OF THIS PROJECT IS TO DETERMINE THE FEASIBILITY OF EXPLOITING ANTIGEN-ANTIBODY BINDING IN THE ORGANIC PHASE. A SE ...

    SBIR Phase I 1989 National Science Foundation
  3. HETEROLOGOUS PROTEIN EXPRESSION IN NEUROSPORA

    SBC: Hawaii Biotech, Inc.            Topic: N/A

    THE PROPOSED RESEARCH WILL INVESTIGATE THE ABILITY OF NEUROSPORA CRASSA TO EXPRESS AND SECRETE BIOLOGICALLY-ACTIVEMAMMALIAN PROTEINS. THE ABILITY TO GENETICALLY ENGINEER BACTERIA AND YEASTS FOR THESE TASKS IS WELL DOCUMENTED. HOWEVER, RECOMBINANT PRODUCTS FROM THESE ORGANISMS OFTEN REQUIRE COSTLY DOWNSTREAM PURIFICATION AND PROCESSING. THE PHYSIOLOGY OF THE FILAMENTOUS FUNGI INDICATE THAT THEY ARE ...

    SBIR Phase I 1989 National Science Foundation

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