Award Data

DESCRIPTION provided by applicant Acute ischemic stroke AIS is the result of a blood clot in a cerebral artery It remains a leading killer and the leading cause of long term disabilit annually impacting over Americans Because brain tissue rapidly dies time to reperfusion is critical in both preventing death and improving neurological outcomes While current annual costs relat ...

DESCRIPTION provided by applicant RNA interference RNAi is a small RNA guided gene silencing process within living cells The RNAi technique is widely used in both biological research and clinical applications because it has the ability to knockdown essentially any gene of interest However one major unresolved issue in RNAi studies is non specific gene silencing It is well known that in ...

DESCRIPTION provided by applicant Cells secrete hormones and neurotransmitter via exocytosis Understanding how exocytosis is regulated and how pharmaceuticals and toxins inhibit exocytosis is of broad medical significance because it aids in developing approaches to treat medical conditions where release of transmitter needs to be enhanced e g Parkinsonandapos s disease or inhibited e g ...

DESCRIPTION provided by applicant Type diabetes is an immune mediated disease in which insulin producing beta cells are destroyed resulting in life long dependence on exogenous insulin The number of patients being diagnosed is increasing each year particularly in the very young Despite advances in glucose monitoring and insulin delivery there is a compelling need to identify therapies th ...

DESCRIPTION provided by applicant Wound healing is an intricately regulated process broadly characterized by phases of inflammation proliferation and remodeling Imbalances in any one of these phases can result in inadequate healing scar formation or in the development of chronic wounds such as diabetic ulcers Diabetic ulcers are responsible for the majority of lower extremity amputations ...

DESCRIPTION provided by applicant Despite evidence that inflammatory mechanisms initiate and complicate pathophysiology in pulmonary arterial hypertension PAH no strategies have been developed to target the inflammatory cells involved Moreover it has been known for years that autoimmune diseases are associated with certain forms of PAH Hence novel therapy is urgently needed to attenuate ...

DESCRIPTION provided by applicant Racial and ethnic minorities older adults and those from rural communities continue to be underrepresented in cancer and other clinical trials research despite annual spending on patient recruitment in excess of $ billion While many individual studies have demonstrated that targeted outreach and education to underrepresented patients and engagement of fro ...

DESCRIPTION provided by applicant Neuropathic pain such as diabetic neuropathic pain DNP can be difficult to treat with only of patients achieving meaningful andgt pain relief Current therapies e g duloxeline mainly address symptoms by focusing on blocking neurotransmission in the pain pathway with limited efficacy potentially severe side effects and narrow therapeutic in ...

DESCRIPTION provided by applicant Storage and maintenance of valuable genotypes of animal model species as live animal lines would be wholly impractical However traditional cryopreservation techniques will be soon found to be inefficient for providing economic approach for cryopreservation of cells and tissues from millions of new animal models being developed Efficient cryopreservation of c ...

DESCRIPTION provided by applicant The goal of this project is to provide a synthetic biomaterial capable of giving long term repair of full thickness chondral lesions with the aim of helping to reduce the joint replacements carried out each year in the USA Our company has developed a synthetic biomaterial technology with proven biocompatibility in treating over patients for bon ...