Award Data

The objective of the Phase II research is to utilize the lessons learned from the Phase I risk reduction work to develop a prototype CAD-programmable environment for the development of condition-based maintenance systems for rotorcraft. This developmentenvironment features a CAD scenario modeler for constructing, via click n' drag modeling, fault-to-failure damage models which can account for the ...

The objective of the Phase II research is to utilize the lessons learned from the Phase I risk reduction work to develop a prototype CAD-programmable environment for the development of condition-based maintenance systems for rotorcraft. This developmentenvironment features a CAD scenario modeler for constructing, via click n' drag modeling, fault-to-failure damage models which can account for the ...

DESCRIPTION (provided by applicant): EIderly falls constitute one of the most costly health problems in the U.S., both in terms of expense to the healthcare system and in individual suffering. Fully one-third of people over age 65 fall each year, many incurring significant injuries that strongly impact their long-term health prospects and productivity. Although many factors contribute to the prop ...

DESCRIPTION (provided by applicant): EIderly falls constitute one of the most costly health problems in the U.S., both in terms of expense to the healthcare system and in individual suffering. Fully one-third of people over age 65 fall each year, many incurring significant injuries that strongly impact their long-term health prospects and productivity. Although many factors contribute to the prop ...

DESCRIPTION (provided by applicant): The goal of this project is to use an infection-independent cell-based assay to identify compounds that inhibit respiratory syncytial virus (RSV). The basis of this bioassay is expression of a reporter gene from an artificial viral genome present within the cytoplasm of transfected cells. Significant advances have been made in identifying the cis-acting elem ...

DESCRIPTION (provided by applicant): The goal of this project is to use an infection-independent cell-based assay to identify compounds that inhibit respiratory syncytial virus (RSV). The basis of this bioassay is expression of a reporter gene from an artificial viral genome present within the cytoplasm of transfected cells. Significant advances have been made in identifying the cis-acting elem ...

DESCRIPTION (provided by applicant): Respiratory syncytial virus (RSV) is the most important respiratory pathogen in infants, especially those born prematurely. It is also an important cause of disease in the elderly and immunosuppressed. There is no vaccine available to protect against RSV and "at risk" infants are presently treated by passive immunization. An effective small molecule drug that ...

DESCRIPTION (provided by applicant): The drug discovery industry is under increasing pressure to rapidly prioritize compound candidates based on their efficacy and specificity. Although traditional chip based gene expression microarrays can provide significant insights, sample format and throughput considerations preclude more widespread use. Microtiter plate based microarray (MPMA) systems can be ...

DESCRIPTION (provided by applicant): A computer controlled switching stimulator/amplifier is proposed which is capable of delivering electrical stimuli between pairs of intracranial electrodes, while simultaneously monitoring the EEG potentials on all implanted electrodes immediately before and after stimulus application In phase 1, a key feasibility issue will be to study the electro-chemical ef ...

DESCRIPTION (provided by applicant): Bacterial contamination of blood products is currently a major problem in transfusion medicine and a leading cause of transfusion-related deaths. Platelets are particularly susceptible to contamination because they are stored at room temperature. BCR Diagnostics, Inc. (BCR) has developed a novel biosensor platform for detecting low levels of bacteria in r ...