Award Data

ABSTRACT Sanaria s Plasmodium falciparumPfsporozoiteSPZvaccines development program is receiving global supportTrials of PfSPZ Vaccineradiation attenuated PfSPZor PfSPZ CVacPfSPZ Chemoprophylaxis Vaccineadministered by direct venous inoculationDVIincludingadults to infants were initiated in DecemberTanzaniaU Sor will be initiated in earlyin MaliKenyainfantsGhanaEquatorial GuineaGermany andaddition ...

DESCRIPTIONprovided by applicantThe world needs a highly effective malaria vaccineSanaria rPfSPZ Vaccinecomposed of asepticpurifiedcryopreserved radiation attenuated PfSPZprotectedof volunteers in an NIH clinical trialThe vaccine has been administered by direct venous inoculationDVItosubjects in MaliTanzaniaEquatorial GuineaEGand USASafetytolerabilityhigh grade protectionheterologous protection af ...

A NEW HOLOGRAPHIC D CAMERA FOR FUNDUS IMAGING Abstract In the United States retinal disease is the most common cause of visual impairment with age related macular degeneration AMD and diabetic retinopathy DR being the most common retinal diseases For each of the above conditions high resolution and three dimensional D imaging of the retina retinal vasculature choroid and or retinal ...

DESCRIPTION provided by applicant In this Fast Track application a path to commercialization will be pursued for a breakthrough andquot genetic cytologyandquot test capable of detecting both ovarian and endometrial cancer from routinely collected Pap specimens In deference to the notable success of the Pap test in reducing deaths due to cervical cancer and in reference to the core enabling ...

Project Summary Abstract Radiofrequency ablation RFA is a minimally invasive method used to treat solid tumors commonly primary liver cancers and metastases which are accessible percutaneously via a sharp needle Imaging guidance typically by ultrasound or CT is required for probe placement but these methods are incapable of monitoring the progress of the procedure Additional imaging sessi ...

Summary The long term objective of the project is to implement new motion robust magnetic resonance imagingMRItechnology into wide clinical and research useMagnetic resonance imaging is a powerful tool that aids in the diagnosis of individual subjectsguides their clinical careand provides insights into the mechanisms of normal and atypical developmentThe characterization of mental health disorders ...

Summary Breast cancer is the second most common and the major cause of cancer related death of women in the USA The last decade has witnessed major advancement of therapeutic drugs and tools while noninvasive diagnostic imaging tools to measure interventions received much less attention Currently the mainstay of noninvasive imaging in breast cancer relies primarily on anatomic imaging Metabol ...

DESCRIPTION provided by applicant Venezuelan Equine Encephalitis virus VEEV is a life threatening NIH NIAID category B human pathogen and a potential bioterrorism threat Outbreaks of VEEV occur in Central America and have previously spread into the United States The potentially devastating effects of the virus reemergence in the U S demand an effective vaccine to protect population Curr ...

` The goal of this project is the development of a scalable n x m electrochemical detector array platform with on chip amplifiers for massively parallel recordings of quantal transmitter release events The neurobiological process that this assay analyzes is the process of exocytosis and transmitter release Neurotransmitters and hormones are stored at high concentration in membrane bound organel ...

DESCRIPTIONprovided by applicantNational surveillance data confirm thatof Abaumannii isolates from US intensive care units are extreme drug resistanceXDRfar higher than other pathogensAt leastandcases of XDR Abaumannii infections occur annually in the US and globallyin developed countriesrespectivelyThese infections result inanddeaths and excess healthcare costs of $million and $million in the US ...