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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

Displaying 1 - 10 of 3340 results
  1. A Circulating Biomarker for use in Monitoring Metastatic Breast Cancer

    SBC: A&G PHARMACEUTICAL, INC.            Topic: NCI

    Cost effective and minimally invasive monitoring of metastatic breast cancerMBCpatients for disease progression or response to therapy is an unmet need in the clinical management of the diseaseImaging technologies are currently the gold standard of such monitoringHoweverthere is controversy regarding the type andampfrequency of imaging requiredImaging is expensivetime consumingslow to detect disea ...

    SBIR Phase II 2018 Department of Health and Human Services
  2. Pharmacology & human Phase 1 safety & dose escalation studies using anti-GP88 in aggressive breast cancer

    SBC: A&G PHARMACEUTICAL, INC.            Topic: 102

    Innew cases of breast cancerBCandrelated deaths are expected in the USof these are patients with aggressive triple negative BCTNBCor anti estrogen aromatase inhibitor resistantAE AIBC that do not have targeted therapy and rely on radiotherapy and aggressive chemotherapyA new approach that benefits these patients and provides increased life expectancy needs to be developedWe have identified GPa gly ...

    SBIR Phase I 2018 Department of Health and Human Services
  3. TheSieve

    SBC: Cyber Point International, LLC            Topic: None

    CyberPoint International presents the design of a cross platform product for the autonomous execution of live forensic investigations of Personal Computers, Laptops and Servers leveraging the NIST NSRL corpus and a combination of at least 3 forms of machine learning/artificial intelligent algorithms for the processing of preliminary digital evidence titled TheSieve. We build upon work from our pha ...

    SBIR Phase II 2019 Department of CommerceNational Institute of Standards and Technology
  4. TB Diagnostics at the Point of Care

    SBC: AKONNI BIOSYSTEMS INC.            Topic: NIAID

    ABSTRACT Tuberculosis ranks in the top ten worldwide cause of death and now ranks ahead of HIVmaking it the number one infectious disease killerPerhapsmost alarming is the global prevalence of multidrug resistant TBMDRTBand extensively drug resistant TBXDR TBmore thanof new TB cases are MDR TB andof these have XDR TBAndthe number of enrolled XDR TB cases has grown fromcountries intoinThe concern t ...

    SBIR Phase II 2018 Department of Health and Human Services
  5. Commercialization of an Ultrasound-guided Vascular Access Device

    SBC: PERCEPTIVE NAVIGATION LLC            Topic: NHLBI

    PROJECT SUMMARY Safe and reliable access to major blood vessels and internal organs will be beneficial to patients with cardiovascular and cardiothoracic diseasesAn interventional catheter with forward viewing ultrasound imaging capability will be developed to enable image guided access to blood vessels and internal organsPhaseandexperiments demonstrate feasibility of building a high resolutionfor ...

    SBIR Phase II 2018 Department of Health and Human Services
  6. AVGN7, a Novel Gene Therapeutic for Treating Cancer Cachexia

    SBC: Aavogen, Inc.            Topic: 102

    PROJECT SUMMARYThe skeletal muscle wasting that occurs with cancer cachexia compromises quality of life and is both directly and indirectly responsible for cancer mortalitiesTumor derived and tumor responsive factors as well as many therapeutics themselves contribute to the cachectic statealthough nutritional support has little if any positive effect on restoring striated muscle mass or functionTh ...

    SBIR Phase II 2017 Department of Health and Human Services
  7. A clinical process support system for primary care to address family stress

    SBC: Total Child Health, Inc.            Topic: NICHD

    This proposal addresses the NICHD focus of specific interest for the prevention of child abuse and neglect in at risk populationsChild abuse and neglect often confers shortand long term impairment of the physicalemotionaland cognitive development of childrenThe proposed project builds on promising data from previous randomized control trialsbased on application of a screening tool in primary care ...

    SBIR Phase II 2017 Department of Health and Human Services
  8. Optimization of an innate immune stimulating adjuvant for an HIV DNA vaccine

    SBC: PROFECTUS BIOSCIENCES, INC.            Topic: NIAID

    Abstract There is a growing consensus that protection against HIV infection will require BOTH antiviral antibody responses as well as polyfunctional CDand CDT cells with potent lytic activityTo stimulate the breadthpotencyand rate of response requiredProfectus Biosciences intends to utilize its platform technologies based on DNA vaccines combined with genetic adjuvantsAs a step in that directiona ...

    SBIR Phase II 2018 Department of Health and Human Services
  9. Pivotal trial of vamorolone in Duchenne muscular dystrophy

    SBC: ReveraGen BioPharma, Inc.            Topic: NINDS

    Abstract ReveraGen BioPharma is a clinical stage drug development company that is developing vamoroloneVBPa first in class dissociative steroidal drugThe initial indication being tested is Duchenne muscular dystrophyDMDwhere vamorolone holds promise for retaining or increasing efficacy of glucocorticoidswhile reducing adverse effectsbone fragilitystunting of growthweight gaininsulin resistanceReve ...

    SBIR Phase II 2018 Department of Health and Human Services
  10. Development of Reagents for Sequencing Proteins and Protein Fragments on a Next-Generation DNA Sequencer

    SBC: Encodia, Inc            Topic: 100

    ABSTRACT Next generation sequencingNGShas transformed the field of genomics and enabled broad adoption of the technology in biologicaltranslationaland most recently clinical researchThe proteomics equivalent to NGS has not yet been realizedAs suchthe goal of this proposal is to develop a highly scalable digital protein analysis technologyThe approach is broadly applicable and greatly improves upon ...

    SBIR Phase II 2018 Department of Health and Human Services

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