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DESCRIPTION provided by applicant Dysregulation of apoptosis pathways and loss of Human Beta Defensin hBD are the common tactics adapted by cancer cells to circumvent the effects of chemotherapy Consequently high dose of chemotherapy is required to obtain a clinically relevant therapeutic index which in turn compromises safety and develops resistance to therapy The problem is acute p ...

A BATTERY OF 29 RELIABLE, VALID, AND REPEATABLE COGNITIVE AND PSYCHOMOTOR PAPER-AND-PENCIL TESTS, EACH PURPORTING TO MEASURE A SPECIFIC CONSTRUCT, WILL BE USED TO ASSESS PERFORMANCE OF 48 OLDER MALES AND FEMALES IN THREE SEPARATE AGE GROUPS (55-60, 65-70, 75-80 YEARS). A GROUP OF 16 MEN AND WOMEN AGED 25 TO 35 WILL SERVE AS THE CONTROL. THIS BATTERY WILL BE DIVIDED INTO THREE SUB-BATTERIES; THEY W ...

DESCRIPTION (provided by applicant): The low frequency cardiac rhythm (LFCR) is an innovative, but underutilized, biological marker. The PI's studies show that LFCR is strongly associated with the state of cognitive persistence in controls. Cognitive persistence refers to the ability to remain on-task and inhibit impulsive off-task behavior. Additional preliminary data also suggest that children w ...

DESCRIPTION (provided by applicant): The low frequency cardiac rhythm (LFCR) is a promising biological marker for psychological research. The primary goal of this project is to make the LFCR methodology more accessible to researchers by providing a both a product and extensive support services. In Phase I, a prototype system was built and used to collect simultaneous physiological and cognitive da ...

We propose to develop an innovative, compact ultrafast high brightness laser source, broadly tunable in the infrared for vibrationally-resolved infrared microscopy and other applications. By passive Kerr lens mode-locking of a novel diode-pumped tunable Cr:LiSAF laser, 100fs pulses will be generated at 100 MHZ repetition rate with an average power of 1W. An optical parametric oscillator (OPO) pump ...

PROJECT SUMMARY Klebsiella pneumoniae is an encapsulated human pathogen capable of causing a myriad of human infections. Recently, K. pneumoniae has also emerged as one the most common causes of secondary bacterial pneumonia in COVID-19 patients. Over the last 40 years, K. pneumoniae has evolved into two distinct pathotypes, known as classical K. pneumoniae (cKp) and hypervirulent K. pneumoniae (h ...

Project Summary Galactic Core LLC aims to develop a robust, scalable, and managed service for performing enterprise-grade biomedical data analysis. The service will be based on the popular open-source Galaxy application (​https://galaxyproject.org/​), offering unlimited data storage and compute capabilities with an extremely powerful, flexible, and collaborative environment for analyzing data. ...

This proposal will emphasize outfitting a virtual classroom and creating a skills (CNC) oriented training program. The virtual classroom will involve contextual learning using a realistic simulation of the manufacturing environment. The simulation will have all of the characteristics of a machine shop, but will allow the learner to explore and experiment ("discover") in ways that would not be pr ...

The Internet is an evolving web of interconnected computer networks offering information resourcesinfinite proportions. Unfortunately, the computer lay person experiences formidable barriers to accAwkward commands and clumsy menus are intimidating - attempting to navigate Internet can be likenedforeign country without a map and with no grasp of the language. Compounding this problem is the fainf ...

DESCRIPTION (provided by applicant): Phase I The primary objective of the SBR effort proposed herein is to investigate the feasibility of significantly enhancing the imaging capacity of diffuse optical tomography (DOT) technology by using a novel 3D image device to provide accurate three-dimensional (3D) geometric boundary conditions in non-contact-detection "3D DOT" systems. The 3D surface image ...