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RECENT ADVANCES IN DIGITAL FLUOROSCOPY HAVE SHOWN THAT GOOD QUALITY PORTAL IMAGES CAN BE PRODUCED INSTANTANEOUSLY AND CONTINUOUSLY DURING HIGH VERSATILE IMAGER WHICH IS EASY TO USE AND IS READILY ACCEPTABLE BY THE RADIATION THERAPY COMMUNITY NEED TO BE DEVELOPED. SINCE THE MODERN RADIATION THERAPY MACHINES ARE ISOCENTRIC, THE FLUOROSCOPIC IMAGER HAS TO BE MULTI-DIRECTIONAL. BUILDING AN IMAGER WHIC ...

THE RESEARCH OBJECTIVE IS TO PROVE THE TECHNICAL FEASIBILITYAND MERIT OF USING VOICE-MESSAGING TECHNOLOGY, I.E., AUDIOTEX, TO DEVELOP AN AUDIO INFORMATION LIBRARY PROTOTYPE TO ASSIST INDIVIDUALS IN PLANNING FOR RETIREMENT AND FINANCIAL SECURITY TO ENSURE A HEALTHY STANDARD OF LIVING FOR OLDER AMERICANS. THE OPERATING HYPOTHESIS IS: A SIGNIFICANT NEED AND GROWING DEMAND FOR RETIREMENT AND FINANCIAL ...

WE WILL DEVELOP A LASER SYSTEM THAT IS SUITABLE FOR PERFORMING PHOTOTHERMAL INTRASTROMAL KERATOPLASTY TO CORRECT OCULAR REFRACTIVE ERRORS. LASER PARAMETERS (WAVELENGTH, IRRADIANCE, AND IRRADIATION TIME) AND DELIVERY/GEOMETRY PARAMETERS (BEAM PROFILE, SPOT SIZE, PATTERN, AND SLEW RATE) SHALL BE OPTIMIZED FOR TREATMENT OF MYOPIA, HYPEROPIA, AND ASTIGMATISM. IN THE PHASE I PROGRAM RESEARCH, A PROTOTY ...

NUMEROUS CLINICAL INVESTIGATIONS HAVE STRONGLY INDICATED THAT HIGH DIETARY INTAKE OF CAROTENOIDS AND RELATED COMPOUNDS CAN REDUCE THE INCIDENCE AND/OR REVERSE THE SYMPTOMS OF CERTAIN TYPES OF CANCER. IF THESE STUDIES CONTINUE TO BE CONFIRMED, CAROTENOIDS MAY INCREASINGLY BE CONSIDERED VALUABLE FOOD ADDITIVES, AS WELL AS CHEMOTHERAPEUTIC AGENTS IN THE PREVENTION AND TREATMENT OF CANCER. FURTHERMORE ...

CYTOTOXIC ACTIVATED MACROPHAGES SECRETE SOLUBLE FACTORS THAT HAVE A VARIETY OF EFFECTS ON TUMOR CELLS. INCLUDED IN THE TUMOR CELL RESPONSE ARE THE INHIBITION OF MITOCHONDRIAL RESPIRATION AND INHIBITION OF DNA SYNTHESIS. A MONOKINE CALLED RIF, WHICH WAS FOUND TO REPRODUCE THESE EFFECTS IN VITRO, HAS BEEN CHARACTERIZED. THE ISOLATION AND VERIFICATION OF THE CDNA FOR RIF IS THE PRIMARY FOCUS OF THIS ...

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THIS PROJECT WILL DEVELOP A SPECTROPHOTOMETRIC INSTRUMENT TO MEASURE THE TOTAL HEMOGLOBIN CONCENTRATION OF WHOLE BLOODAND THE RELATIVE CONCENTRATIONS OF OXY-, DEOXY-, CARBOXY-, MET-, AND SULFHEMOGLOBIN. THE CHIEF STRATEGY IS TO MAKE BEER'S LAW APPLY TO WHOLE BLOOD BY MINIMIZING THE EFFECTS OFLIGHT SCATTERING AND TO EMPLOY MATRIX MATH TECHNIQUES TO SOLVE FOR THE FIVE HEMOGLOBIN CONCENTRATIONS FROM ...

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UROKINASE-LIKE PLASMINOGEN ACTIVATOR (UPA) HAS BEEN IMPLICATED IN TISSUE REMODELING DURING SUCH PROCESSES AS TUMOR METASTASIS, WOUND HEALING AND EMBRYOLOGICAL DEVELOPMENT. SPECIFIC INHIBITORS OF UPA HAVE BEEN DEVELOPED WHICH WILL BE ASSAYED AS INHIBITORS OF EXPERIMENTAL METASTASIS IN A MOUSE MELANOMA MODEL SYSTEM. CONFIRMATION OF A CORRELATION BETWEEN THE UPA INHIBITORY AND ANTI-METASTATIC PROPERT ...