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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. AUTOMATED USER FEEDBACK AND INFORMATION REQUEST DATABASE DEVELOPED FOR A PC

    SBC: Dvp, Inc.            Topic: N/A

    HISTORICALLY, DATABASE MANAGEMENT HAS BEEN A TASK FOR EXPERTS, AND DATABASE MANAGEMENT SYSTEMS (DBMS) HAVE RESIDEDLARGELY ON MAINFRAME COMPUTERS. TODAY, HOWEVER, WITH THE TREMENDOUS VARIETY OF USER-FRIENDLY SOFTWARE, THE POWER OF MICROCOMPUTER HARDWARE, AND THE STORAGE CAPACITY OF PERIPHERALS, MANY DATABASES INITIALLY ESTABLISHED ON MAINFRAME MAY NOW PRACTICALLY BE INSTALLED ON PERSONAL COMPUTERS. ...

    SBIR Phase I 1987 Department of Commerce
  2. ADVANCED SCANNING TUNNELING MICROSCOPE

    SBC: R D Young Consultants Inc            Topic: N/A

    THE SCANNING TUNNELING MICROSCOPE IS AN EVOLVING INSTRUMENT FOR MICROTOPOGRAPHIC MAPPING AND CHEMICAL ANALYSIS OF REFINED SURFACES WITH RESOLUTION ON THE ATOMIC SCALE. THE GOAL OF THIS CONTRACT IS TO PROVIDE A NEW AND INNOVATIVE DESIGN FOR THE STM, EXTENDING ITS FLEXIBILITY AND ACCURACY. MORE SPECIFICALLY, THE DESIGN GOALS ARE: 1) TO PROVIDE A COMPACT INSTRUMENT SUITABLE FOR VACUUM FLANGE MOUNTING ...

    SBIR Phase I 1987 Department of Commerce
  3. EFFECTS OF A HEALTH AND WELL-BEING PROGRAM ON THE ELDERLY

    SBC: Adults Health & Dev Programs            Topic: N/A

    THE HYPOTHESIS TO BE TESTED IS THAT A 7-DAY, HEALTH AND WELL-BEING CAMP (ADULTS HEALTH & DEVELOPMENT PROGRAMS, INC.'S CAMP AHDP) FOR THE "WELL" ELDERLY WILL SIGNIFICANTLY IMPROVE OBJECTIVE AND SUBJECTIVE HEALTH, SYMPTOMATOLOGY, SUBJECTIVE WELL-BEING, AND ASPECTS OF PHYSICAL FITNESS. THE APPROXIMATELY 80 PARTICIPANTS WILL BE INDEPENDENTLY LIVING, RELATIVELY HEALTHY ADULTS BETWEEN AGES 50 TO 90 YEAR ...

    SBIR Phase I 1987 Department of Health and Human Services
  4. PRECISION SHOCK-WAVE GENERATOR FOR MEDICAL TREATMENT AND RESEARCH

    SBC: Advanced Technology & Research            Topic: N/A

    THIS INVESTIGATION INTENDS TO EVALUATE THE CAPABILITY OF AN ESTABLISHED SECTOR SHOCK-TUBE METHOD FOR APPLICATION TO LITHOTRIPSY. IT COULD PROVIDE A QUANTITATIVELY DEFINED SHOCK WAVE IN TERMS OF WAVE PRESSURE, DURATION, ENERGY, AND SPATIAL EXTENT FOR IMPROVED PATIENT TREATMENT AND USE OF SHOCK WAVES IN BIOLOGICAL RESEARCH. THE ONLY AUTHORIZED SHOCK-WAVE LITHOTRIPSY TREATMENT SYSTEM (DORNIER)EMPLOYS ...

    SBIR Phase I 1987 Department of Health and Human Services
  5. SOLUTE-SOLVENT INTERACTIONS IN CHEMISTRY AND BIOLOGY

    SBC: Advanced Technology & Research            Topic: N/A

    THE "SOLVATOCHROMIC PARAMETER" DATABASE WILL BE EXPANDED ANDSOLUBILITY, DISTRIBUTION, AND TOXICOLOGY PROPERTIES (XYZ) OF ORGANIC NONELECTROLYTES WILL BE CORRELATED, RATIONALIZED,AND PREDICTED THROUGH LINEAR SOLVATION ENERGY RELATIONSHIPS OF THE FORM: XYZ = XYZ + MV/100 + S PI* + A ALPHA + B BETA, WHERE V IS A MEASURE OF SOLUTE (TOXICANT) MOLAR VOLUME, AND PI*, ALPHA, AND BETA ARE THE SOLVATOCHROMI ...

    SBIR Phase I 1987 Department of Health and Human Services
  6. NEW TARGET-DIRECTED PT-PORPHYRIN ANTICANCER DRUGS

    SBC: AMT, INC.            Topic: N/A

    THE OBJECTIVE OF THIS PROJECT IS TO IMPROVE THE SELECTIVITY OF ACTION OF PLATINUM ANTITUMOR AGENTS. PLATINUM COMPOUNDS HAVE SHOWN ACTIVITY IN MANY TYPES OF TUMORS, BUT SEVERE DOSE-LIMITING SIDE EFFECTS HAVE AFFECTED THEIR CLINICAL UTILITY. BY DIRECTING THESE AGENTS MORE SPECIFICALLY TO TUMOR SITES, THEIR EFFECTIVENESS SHOULD BE IMPROVED. THE APPROACH USED TO ACHIEVE THIS IMPROVED SPECIFICITY WILL ...

    SBIR Phase I 1987 Department of Health and Human Services
  7. MECHANISM-BASED ELASTASE INHIBITORS

    SBC: AMT, INC.            Topic: N/A

    SYNTHETIC ELASTASE INHIBITORS FOR USE IN THE TREATMENT OF EMPHYSEMA WILL BE DEVELOPED. IN PHASE I, NEW MECHANISM-BASED ELASTASE INHIBITORS WILL BE SYNTHESIZED, CHARACTERIZED, AND STUDIED AS INHIBITORS OF ELASTASE IN VITRO. THESE INHIBITION STUDIES WILL ANALYZE BOTH THE REVERSIBLE BEHAVIOR OF THE INHIBITORS AND THE TIME-DEPENDENT, IRREVERSIBLE ELASTASE INACTIVATION. AFTER THE CHEMISTRY OF THE ELAST ...

    SBIR Phase I 1987 Department of Health and Human Services
  8. RETINOPATHY TREATMENT: HEPARIN-TARGETED ANTIANGIOGENESIS

    SBC: Angiogen, Inc.            Topic: N/A

    PROLIFERATIVE RETINOPATHY, OR OCULAR DISORDERS CHARACTERIZED BY ABNORMAL RETINAL NEOVASCULARIZATION, PRESENTS A SERIOUS CHALLENGE IN OPHTHALMOLOGY. CONVENTIONALTREATMENTS-LASER PHOTOCOAGULATION AND VITRECTOMY-RETARD BUT DO NOT NECESSARILY ABOLISH NEOVASCULARIZATION AND, IN THE PROCESS, PRODUCE SIGNIFICANT SIDE EFFECTS THAT LIMIT THEIR USEFULNESS. IN THE PROPOSED STUDIES, THE CONCEPT OF HEPARIN-TAR ...

    SBIR Phase I 1987 Department of Health and Human Services
  9. MONOCLONAL ANTIBODIES AGAINST THE MHC OF INBRED RATS

    SBC: Analex Space Systems, Inc.            Topic: N/A

    THE OBJECTIVES OF THIS PROPOSAL ARE TO: (1) PRODUCE ALLOTYPIC MONOCLONAL ANTIBODIES THAT DISTINGUISH CLASS I ANDCLASS II ANTIGENS CODED BY THE RTI LOCI MAJOR HISTOCOMPATIBILITY COMPLEX (MHC) IN THE LABORATORY RAT, AND (2) CHARACTERIZE THE ANTI-MHC MONOCLONAL ANTIBODIES BY BIOCHEMICAL AND GENETIC METHODS TO DETERMINE THEIR ANTIGENIC SPECIFICITY FOR CLASS I AND CLASS II ANTIGENS OF DIFFERENT MHC HAP ...

    SBIR Phase I 1987 Department of Health and Human Services
  10. FEASIBILITY DEMONSTRATION OF AN AUTOMATIC SOLUBILITY-MONITORING SYSTEM

    SBC: AUTOMATED PRECISION INC.            Topic: N/A

    A PROGRAM TO DEMONSTRATE THE FEASIBILITY OF AN AUTOMATIC, LASER-SCANNING SOLUBILITY-MONITORING SYSTEM IS PROPOSED. THE SYSTEM IS DESIGNED TO REPLACE CURRENT MANUAL SOLUBILITY-TESTING PROCEDURES PERFORMED IN GOVERNMENT LABORATORIES, PHARMACEUTICAL COMPANIES, AND FOOD INDUSTRIES WITH A MORE ECONOMICAL AND EFFICIENT PROCEDURE. PHASE I EFFORTS WILL BE DIRECTED TO THE DESIGNING, CONSTRUCTION, AND DEMON ...

    SBIR Phase I 1987 Department of Health and Human Services

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