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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Development of a Coastal Long-Term Automated Self-Calibrating Profiler

    SBC: Green Eyes, LLC            Topic: 814

    Green Eyes, LLC will demonstrate the feasibility of a Coastal Long-term Automated Self-calibration Profiler (CLASP) system capable of operating autonomously for one year without servicing. CLASP will be configured to incorporate wireless two-way communications for automated data dissemination and remote control. Two major innovations are required to develop such a system. 1. Automated bio-fouli ...

    SBIR Phase I 2007 Department of Commerce
  2. Novel Targeted Therapy for Breast Cancer

    SBC: A&G PHARMACEUTICAL, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Breast cancer remains one of the top three cancers to affect and cause mortality in women. Major shortcomings with current treatment are the high level of side effects and insufficient efficacy, particularly for patients with metastatic disease. Targeted cancer therapy is designed to treat only the cancer cells and minimize damage to healthy cells. These target ...

    SBIR Phase I 2007 Department of Health and Human Services
  3. Diagnostic protein array for respiratory infections

    SBC: AKONNI BIOSYSTEMS INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The objective of this project is to transition Argonne-developed intellectual property into the commercial marketplace, and develop a protein array for clinical surveillance and diagnosis of common respiratory infections, including influenza A, influenza B, parainfluenza (types 1-3), human respiratory syncitial virus (RSV), adenovirus (types A-f), SARS coronavi ...

    SBIR Phase I 2007 Department of Health and Human Services
  4. Integrated, on-chip RT-MME-PCR for influenza diagnostics; Phase 1 = sample prepar

    SBC: AKONNI BIOSYSTEMS INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Influenza viruses are highly contagious, segmented negative-sense RNA viruses that belong to the family Orthomyxoviridae, causing approximately 114,000 hospitalizations and 20,000 deaths annually. Several drugs are approved by the US Food and Drug Administration (FDA) for treating influenza infections, but successful treatment depends on administering these dru ...

    SBIR Phase I 2007 Department of Health and Human Services
  5. Treatment of diabetic gastroparesis with nitric oxide

    SBC: AMULET PHARMACEUTICALS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): This proposal will establish proof of concept for the use of nitric oxide (NO) as an effective treatment for diabetic gastroparesis. The NO will be delivered using Amulet's NORTECH nitric oxide releasing technology. NORTECH delivers NO in a predictable and controllable manner, and without the possibility of forming carcinogenic nitrosamines. NORTECH is uniquely ...

    SBIR Phase I 2007 Department of Health and Human Services
  6. Gestural Interfaces and Robotics for Rehabilitation

    SBC: Anthrotronix, Inc.            Topic: N/A

    DESCRIPTION (provided by applicant): This Small Business Innovation Research Phase II project is to develop robot-based content to target upper extremity movement therapy goals and evaluate the clinical efficacy of the CosmoBot Robotics System as a therapy intervention for children diagnosed with cerebral palsy, brain injury, and stroke. Cerebral palsy is the most prevalent and one of the three mo ...

    SBIR Phase II 2007 Department of Health and Human Services
  7. The in vitro hepatitis C virus infection system as a drug discovery tool

    SBC: APATH, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Hepatitis C virus (HCV) infection is a major cause of liver disease throughout the world. Existing therapies are suboptimal and the search for alternative therapies is imperative. Recent years have seen a tremendous increase in efforts to identify more effective therapies against HCV. These efforts have been greatly facilitated by sub-genomic HCV replicon syste ...

    SBIR Phase I 2007 Department of Health and Human Services
  8. Development of Novel Bioprocess Platform for Rapid, Economical Production of Pept

    SBC: APC BIOTECHNOLOGY SERVICES, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): A novel bioprocess platform, involving synthesis of peptide and protein biopharmaceutical products as fusions with a synthetic "anchor" protein in bacteria, and subsequent proteolytic cleavage, will be developed. The unique features of the system allow for the economical production of large quantities of simple linear peptides, as well as complex, multi-compone ...

    SBIR Phase I 2007 Department of Health and Human Services
  9. Preclinical Validation of Human Apyrase in Stroke Models

    SBC: APT THERAPEUTICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Human apyrase represents a highly promising therapy for acute ischemic stroke which is a leading cause of death and disability with almost no effective therapy for most patients. This enzyme strongly inhibits platelet activation and aggregation with modest bleeding risk. Using a protein informatics approach, we have successfully engineered a human apyrase, APT1 ...

    SBIR Phase I 2007 Department of Health and Human Services
  10. Apyrase to Treat Ischemia/Reperfusion Injury during Lung Transplantation

    SBC: APT THERAPEUTICS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Human apyrase represents a highly promising therapy to reduce ischemia/reperfusion injury which occurs in10-20% of lung transplant recipients as the consequence of unavoidable processes of procurement, preservation and restoring blood flow. This clinical condition, recently termed primary graft dysfunction, remains an important problem after lung transplantatio ...

    SBIR Phase I 2007 Department of Health and Human Services

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