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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Universal Attenuated Sporozoite Vaccine and Challenge System

    SBC: SANARIA INC.            Topic: NIAID

    ABSTRACT Sanaria s Plasmodium falciparumPfsporozoiteSPZvaccines development program is receiving global supportTrials of PfSPZ Vaccineradiation attenuated PfSPZor PfSPZ CVacPfSPZ Chemoprophylaxis Vaccineadministered by direct venous inoculationDVIincludingadults to infants were initiated in DecemberTanzaniaU Sor will be initiated in earlyin MaliKenyainfantsGhanaEquatorial GuineaGermany andaddition ...

    SBIR Phase II 2016 Department of Health and Human Services
  2. Advancing a Glioma Immunotherapy

    SBC: IN CYTU, INC.            Topic: 102

    DESCRIPTION provided by applicant A Phase II SBIR program of preclinical development is proposed for the development of an active specific immunotherapeutic called Cellariumandquot for treatment of glial cell based cancers Successful completion of this project will confirm therapeutic effect and pre clinical safety of the vaccine in preparation for first in human studies Upon demonstration of ...

    SBIR Phase II 2016 Department of Health and Human Services
  3. Protease chain reactions for molecular analysis of cancer markers

    SBC: POTOMAC AFFINITY PROTEIN, LLC            Topic: 102

    DESCRIPTION provided by applicant Our objective is to develop a Protease Chain Reaction technology ProCR that will enable ultra sensitive and highly quantitative detection of cancer markers The basic element of a protease chain reaction is a protease inhibitor complex The protease is inactive when bound to the inhibitor but once freed is capable of cleaving the inhibitor and releasing ad ...

    SBIR Phase II 2016 Department of Health and Human Services
  4. Software for improved accuracy and rapid tracking of kinematics from dynamic Xray

    SBC: C-MOTION, INC.            Topic: NIAMS

    DESCRIPTION provided by applicant Orthopaedic disorders are a leading cause of disability in the U S with arthritis and or spine problems adversely affecting quality of life fo more than of adults While advances in diagnostic imaging have greatly improved our ability to detect structural changes in musculoskeletal tissues they typically reveal little about joint function There is evid ...

    SBIR Phase II 2016 Department of Health and Human Services
  5. Computerizing NIAAA's Best Practices for Youth Screening and Brief Intervention

    SBC: COG ANALYTICS, LLC            Topic: 400

    DESCRIPTION provided by applicant The early onset of alcohol misuse during adolescence is a widespread problem in the U S Studies have consistently documented both the short and long term adverse neurophysiological impacts and health risk behaviors associated with alcohol misuse during adolescence Given the magnitude of this problem and its myriad consequences preventing early initiation of ...

    STTR Phase I 2016 Department of Health and Human Services
  6. A High Resolution Radiation Therapy Dosimetry system

    SBC: DOSEIMAGING, LLC            Topic: 399

    DESCRIPTION provided by applicant Modern radiation therapy treatment modalities such as intensity modulated radiation therapy are associated with complex dose distributions and sharp dose gradients Experimental dose validation using multidimensional high spatial resolution dosimeters is mandatory The product to be developed is a novel high resolution dosimetry system that combines reusabil ...

    STTR Phase I 2016 Department of Health and Human Services

    SBC: Medical Guidance Systems LLC            Topic: 102

    DESCRIPTION provided by applicant The proposed research is the study of new paradigms in both the treatment of cancer and cancer drug development This platform technology will markedly expand the number of cancer specific surface receptors and antigens that can be targeted for drug delivery using peptide ligands The general principle of this new technology is that cancer cells respond to ioni ...

    STTR Phase I 2016 Department of Health and Human Services
  8. Carbon Fiber Off-Loading Orthosis

    SBC: Orthotic & Prosthetic Design, Inc.            Topic: 200

    DESCRIPTION provided by applicant This proposed project will further develop a CFC off loading AFO designed to offload plantar pressures and optimize patient function through maximizing plantarflexor power production During Phase I we will determine the effects of varying design characteristics of CFC off loading AFOs We will refine and create new FEA models and algorithms that predict the ...

    STTR Phase I 2016 Department of Health and Human Services
  9. Preclinical Testing of Tetrandrine against Noise-Induce Hearing Loss

    SBC: GATEWAY BIOTECHNOLOGY, INC.            Topic: R

    DESCRIPTION provided by applicant Noise is the most common occupational and environmental hazard thus it is not surprising that noise induced hearing loss NIHL is the second most common form of sensorineural hearing deficit second only to age related hearing loss Although therapeutics that target the free radical pathway have shown promise for reducing NIHL there are no medications approv ...

    STTR Phase I 2016 Department of Health and Human Services
  10. Effectiveness of VBP15, a dissociative steroidal analogue, on chronic inflammation in a mouse model of multiple sclerosis

    SBC: ReveraGen BioPharma, Inc.            Topic: NIAID

    DESCRIPTION provided by applicant Glucocorticoids GCandapos s such as prednisolone are used frequently to induce remission and treat multiple sclerosis MS Despite effectiveness many GC mediated detrimental side effects including osteoporosis and muscle atrophy limit long term chronic treatment of MS patients These side effects are believed to be mediated by well described glucocorticoi ...

    STTR Phase I 2016 Department of Health and Human Services

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