Award Data

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We will develop a computer-assisted system to improve the ability of breast sonography to distinguifrom benign lesions. These are lesions originally detected by mammography and sent to ultrasound forThe lesions are biopsied when they are classified by ultrasound as solid or indeterminate, even thoubenign at biopsy. Because of the large numbers of breast biopsies being performed, even a small impro ...

Reuse in software engineering is an exciting concept that has yet to be reliably implemented. The number of program subroutines that are truly generic (and therefore applicable across all applications) is limited. However, there are specific applications that are required by many organizations, albeit with a set of constraints specific to each organization. This project proposes to design a too ...

The requirements of complex sample monitoring present a growing need for a new generation of highlyenzyme electrodes that operate in non-processed or raw samples and have multi-analyte capability. This to establish the feasibility of novel colloidal gold/immobilized enzyme based raw sample/multi-anspecific objective is to develop a biosensor that can measure high density lipoproteins in whole bloe ...

In this grant, we seek to fully implement one aspect of our overall long term goal of developingadvanced instrumentation and reagents for ion and second messenger imaging and analysis. Ourinstrumentation development efforts have-proceeded quite well in the area of hardware and softwareto support any combination of dual excitation and or dual emission fluorescent ratio imaging. We willapply our uni ...

This project identifies the state and local child welfare agencies that are doing the best job in securing access to SSI on behalf of children in substitute care, 2) documents the Best Practices of those jurisdictions, 3) pretests a screening tool, 4) develops a Training and Technical Assistance Package, and 5) develops a marketing strategy for making the screening tool available to state and loca ...

Dysfunctional genes and aberrant expression of regulatory genes are speculated to be key events intumorigenesis. In prostate cancer, unlike many other types of cancer, few consiSuitent genetic alterFrequently, genetic alterations including deletions and amplifications of certain chromosomal regionundefined oncogenes and tumor suppressor genes may also play a role in prostate cancer development.det ...

We will develop a ligase chain reaction (LCR) method to detect mutations in the dihydrofolate reducgene of Plasmodium falciparum. Mutations at codon 108 of this gene have been shown to correlate withresistance. The specific aims of the project are to develop an LCR method for detection of DHFR mutamethod against both known drug sensitive and resistant isolates and assay uncharacterized isolates fT ...

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