Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. NUCLEASE A IN BACILLUS SUBTILIS INTERACTIVE EXPERT EDITING SUBSYSTEM LOW-COST HRPT DIRECT READOUT STATION

    SBC: Genex Corpon            Topic: N/A

    BOVINE PANCREATIC RIBONUCLEASE A (RNASE A) IS A MODEL SYSTEMFOR ESTABLISHING RULES THAT GOVERN PROTEIN STABILITY AND FOLDING. BY LEARNING AND APPLYING THESE RULES, MORE ROBUST ENZYMES OF VARIOUS TYPES COULD BE DESIGNED FOR COMMERCIAL APPLICATIONS. SYNTHESIS, CLONING AND EXPRESSION IN BACILLUSSUBTILIS OF A GENE ENCODING RNASE A WILL ALLOW FOR THE ECONOMICAL PRODUCTION OF VARIANT PROTEINS WHICH ARE ...

    SBIR Phase I 1986 Department of Commerce
  2. INTERFACE

    SBC: American Biotechnology Co            Topic: N/A

    A MAJOR OBJECTIVE OF THIS STUDY IS TO INVESTIGATE THE UTILITY OF A NEW AND INNOVATIVE LIQUID MICROCARRIER (MC) SYSTEM FOR CLONING AND PROPAGATING HUMAN TUMOR CELLS IN VITRO. THIS NEW PATENTED TECHNOLOGY IS AN OIL EMULSION OF DEFINED DROPLET SIZE (100 TO 200 MM) HAVING A SMOOTH, PLIABLE, AND TRANSPARENT SURFACE. THE PROTEIN AT THE OIL EMULSION INTERFACE CAN DIRECTLY SUPPORT THE GROWTH OF TRANSFORME ...

    SBIR Phase I 1986 Department of Health and Human Services
  3. THE COMPLEX 4-CARBOXYPHTHALATO (1, 2-DIAMINOCYCLOHEXANE) PLATINUM (NSC 271674; DACH-PT) HAS UNDERGONE LIMITED CLINICAL TRIALS.

    SBC: AMT, INC.            Topic: N/A

    THE COMPLEX 4-CARBOXYPHTHALATO (1, 2-DIAMINOCYCLOHEXANE) PLATINUM (NSC 271674; DACH-PT) HAS UNDERGONE LIMITED CLINICAL TRIALS. DESIGNED AS AN ALTERNATIVE THERAPY TO CISPLATIN, IT HAS DEMONSTRATED SUBSTANTIALLY REDUCED TOXICITY AND ENHANCED ACTIVITY IN TUMORS RESISTANT TO CISPLATIN IN ANIMALS STUDIES, RESULTS CONFIRMED IN THE CLINIC. HEAVILY PRETREATED PHASE I AND PHASE II PATIENTS RESPONDING TO DA ...

    SBIR Phase I 1986 Department of Health and Human Services
  4. VASCULARIZATION OF MANY SOLID TUMORS OCCURS IN VIVO AS A CONSEQUENCE OF THE VECTORIAL GROWTH OF HOST CAPILLARY ENDOTHELIAL CELLS ALONG A CONCENTRATION GRADIENT OF TUMOR- PRODUCED, DIFFUSIBLE ANGIOGENESIS FACTOR(S).

    SBC: Angiogen, Inc.            Topic: N/A

    VASCULARIZATION OF MANY SOLID TUMORS OCCURS IN VIVO AS A CONSEQUENCE OF THE VECTORIAL GROWTH OF HOST CAPILLARY ENDOTHELIAL CELLS ALONG A CONCENTRATION GRADIENT OF TUMOR- PRODUCED, DIFFUSIBLE ANGIOGENESIS FACTOR(S). THE IDENTIFICATION OF ONE OF THESE FACTORS AS "ANGIOGENIC COPPER" RAISES THE POSSIBILITY THAT COPPER CHELATORS CAN FUNCTION AS ANTIANGIOGENIC AGENTS. THE SPECIFIC AIMS OF THIS PHASE I S ...

    SBIR Phase I 1986 Department of Health and Human Services
  5. THE PROPOSED STUDY TARGETS THE WELL-VASCULARIZED AND REFRACTORY CLASS OF CENTRAL NERVOUS SYSTEM (CNS) TUMORS FOR THE DEVELOPMENT OF NOVEL METHODS FOR DETECTING THE PRESENCE AND QUANTITATING AMOUNTS OF SPECIFIC TUMOR-PRODUCED ANGIO- GENESIS FACTORS (AF).

    SBC: Angiogen, Inc.            Topic: N/A

    THE PROPOSED STUDY TARGETS THE WELL-VASCULARIZED AND REFRACTORY CLASS OF CENTRAL NERVOUS SYSTEM (CNS) TUMORS FOR THE DEVELOPMENT OF NOVEL METHODS FOR DETECTING THE PRESENCE AND QUANTITATING AMOUNTS OF SPECIFIC TUMOR-PRODUCED ANGIO- GENESIS FACTORS (AF). CELL HOMOGENATES AND CONDITION MEDIA FROM CELL CULTURES OF ANIMAL AND HUMAN CNS TUMORS WILL BE EMPLOYED IN THE PHASE I STUDIES. TWO KINDS OF AF MO ...

    SBIR Phase I 1986 Department of Health and Human Services
  6. A PILOT SERIES OF THREE COMPUTER-INTERACTIVE VIDEODISK (CIVD) MODULES WILL BE DEVELOPED FOR TEACHING TOPICS IN TRANSFUSION MEDICINE (TM).

    SBC: Art And Science Graphics            Topic: N/A

    A PILOT SERIES OF THREE COMPUTER-INTERACTIVE VIDEODISK (CIVD) MODULES WILL BE DEVELOPED FOR TEACHING TOPICS IN TRANSFUSION MEDICINE (TM). THE CONTENT OF THE CIVD MODULES IS DETERMINED FROM THE NHLBI NATIONAL TM CURRICULUM AND INCORPORATES BOTH THE ETHICAL AND PSYCHOSOCIAL ISSUES INVOLVED IN THE PRACTICE OF TM. THE AUDIOVISUAL ELEMENT OF THE CIVD PACKAGES WILL BE SUPPLEMENTED BY APPROPRIATE WRITTEN ...

    SBIR Phase I 1986 Department of Health and Human Services
  7. CREATION OF PDQ PROGRAM ON QUESTIONABLE CANCER THERAPIES

    SBC: Barnett Technical Services            Topic: N/A

    N/A

    SBIR Phase I 1986 Department of Health and Human Services
  8. THE LONG-TERM OBJECTIVE OF THIS PROJECT IS TO ESTABLISH NOVEL RECIPIENT EPITHELIAL CELL SYSTEMS THAT WILL DETECT A WIDE SPECTRUM OF ONCOGENES THROUGH DNA TRANSFECTION.

    SBC: Biological Research Faculty &            Topic: N/A

    THE LONG-TERM OBJECTIVE OF THIS PROJECT IS TO ESTABLISH NOVEL RECIPIENT EPITHELIAL CELL SYSTEMS THAT WILL DETECT A WIDE SPECTRUM OF ONCOGENES THROUGH DNA TRANSFECTION. THREE TYPES OF LIVER CELLS REPRESENTING DIFFERENT STAGES OF THE CARCINOGENIC PROCESS WILL BE USED: A NORMAL DIPLOID, AN IMMORTALIZED ANEUPLOID, AND A MUTANT CELL LINE THAT IS TEMPERATURE SENSITIVE FOR TRANSFORMED PHENOTYPE. SPECIFIC ...

    SBIR Phase I 1986 Department of Health and Human Services
  9. ANTIBODY-MEDIATED DETECTION SYSTEMS FOR ACROLEIN-DNA ADDUCTS

    SBC: Biological Research Faculty &            Topic: N/A

    N/A

    SBIR Phase I 1986 Department of Health and Human Services
  10. PRODUCTION OF MODULATORS OF CELL PROLIFERATION

    SBC: Biological Research Faculty &            Topic: N/A

    N/A

    SBIR Phase I 1986 Department of Health and Human Services
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