Award Data

A BATTERY OF 29 RELIABLE, VALID, AND REPEATABLE COGNITIVE AND PSYCHOMOTOR PAPER-AND-PENCIL TESTS, EACH PURPORTING TO MEASURE A SPECIFIC CONSTRUCT, WILL BE USED TO ASSESS PERFORMANCE OF 48 OLDER MALES AND FEMALES IN THREE SEPARATE AGE GROUPS (55-60, 65-70, 75-80 YEARS). A GROUP OF 16 MEN AND WOMEN AGED 25 TO 35 WILL SERVE AS THE CONTROL. THIS BATTERY WILL BE DIVIDED INTO THREE SUB-BATTERIES; THEY W ...

DESCRIPTION (provided by applicant): Radikal Therapeutics is developing a novel small molecule therapy (R-801) for neonatal prematurity that triggers an endogenous cytoprotective defense and thereby blocks pulmonary inflammation and acute lung injury (ALI). R-801 is formed from the covalent fusion of 2 moieties with demonstrated tissue protective properties: 1) a mito-K+-ATP channel activating do ...

DESCRIPTION (provided by applicant): Drug-induced hepatotoxicity is the most common cause of acute liver injury, a potentially fatal condition for which current therapies are limited o supportive care and liver transplantation. It is also the most common reason that potentially life-saving drugs are abandoned during development and never reach patients. Heprotech Inc. was formed to develop liver-s ...

DESCRIPTION (provided by applicant): Substance abuse treatment is often complicated by a client's family, employment, psychiatric, or legal problems. When these co-existing issues are addressed with evidence-based practices (EBPs), outcomes improve. The expansion of EBPs is especially important regarding Medication-Assisted Treatment (MAT), which is the subject of a number of federal and stat ...

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DESCRIPTION: Plant-derived secondary metabolites have proven to be a rich source of pharmaceuticals. From 1981 to 2010, over 65% of the 1355 new chemical entities introduced worldwide were natural products or natural product derivatives. The benzylisoquinoline alkaloids (BIAs) represent a diverse class of secondary metabolites (2500 known structures) with a broad range of pharmacological activiti ...

THE LONG TERM OBJECTIVES OF THIS RESEARCH ARE TO IMPLEMENT AAND EVALUATE NOVEL ADAPTIVE ELECTROCARDIOGRAPHIC DIGITAL S SIGNAL PROCESSING TECHNIQUES. THESE TECHNIQUES OFFER PO POTENTIAL DIAGNOSTIC AND MONITORING VALUE IN THE FIELD OF ELECTROCARDIOGRAPHY (ECG) AND FETAL HEART RATE (FHR) MONITORING. THE SPECIFIC AIMS OF THIS RESEARCH ARE TO ASSESS THE SPEED AND EFFECTIVENESS OF AN ADAPTIVE REAL-TIME ...

DESCRIPTION (provided by applicant): Treatment of Human papillomavirus (HPV) infections is a major unmet medical need. Importantly, the licensed HPV vaccines are not able to clear existing infections, and there are now multiple FDA-approved tests to detecthigh risk HPV DNA, and specifically HPV16. As these HPV DNA tests are widely implemented, large numbers of infected patients are being identifie ...

DESCRIPTION (provided by applicant): X-ray computed tomography (CT), which is widely used clinically, does not make full use of the spectral dependence of X-ray attenuation in tissues and contrast agents, and for that reason it delivers sub-optimal imagesat greater than necessary dose to the patient. CT alone contributes almost half the total radiation exposure for medical use in the US, and one q ...

DESCRIPTION (provided by applicant): Physical Sciences Inc. and its collaborators at Medical Modeling Inc. and the Brigham and Women's hospital propose to develop software for planning maxillofacial surgery. The software will complement the OsteoMark system under development at PSI and will be integrated with the current surgical planning process used by many surgeons. Current software for p ...