Award Data

DESCRIPTION provided by applicant Between and the Center for Social Innovation LLC C developed and evaluated a prototype of the Motivational Interviewing Simulator An Experiential Online Training Tool The interactive case based multiplayer web based game allows service providers to deepen their skills in Motivational Interviewing MI a widely recognized evidence based prac ...

DESCRIPTION provided by applicant The goal of this Phase IIB SBIR application is to test the Sentien cellular bioreactor product the Sentinelandquot in a first in man study to assess safety and preliminary efficacy Fifteen post cardiac surgery patients that are diagnosed with acute kidney injury and indicated for dialysis will be enrolled and connected to the Sentinel containing one of thre ...

DESCRIPTION provided by applicant The ideal most effective tool for eliminating Plasmodium falciparum Pf the causative agent of of all malaria deaths is a highly effective vaccine that prevents blood stage infection and thereby prevents both disease and transmission Sanariaandapos s goal is to develop and commercialize a Pf sporozoite SPZ vaccine that prevents Pf blood stage infect ...

DESCRIPTION Based on the prevailing evidence we believe that a highly effective vaccine for HIV prophylaxis must induce long lasting broadly cross reactive antibody responses to envelope that exhibit antiviral activity as well as multi antigen polyfunctional CD and CD T cell responses that produce antiviral chemokines and cytokines and are possibly biased towards an effector memory phenot ...

DESCRIPTION provided by applicant Dysregulation of apoptosis pathways and loss of Human Beta Defensin hBD are the common tactics adapted by cancer cells to circumvent the effects of chemotherapy Consequently high dose of chemotherapy is required to obtain a clinically relevant therapeutic index which in turn compromises safety and develops resistance to therapy The problem is acute p ...

DESCRIPTION provided by applicant The proposed project will further develop marketable ELISA and lateral flow immunoassay diagnostics LFI in both monoplexed and multiplexed formats for the NIAID category A BSL filoviruses and will drive pre clinical development and validation for these diagnostics These assays will be used for diagnosis of Ebola virus EBOV Sudan virus SUDV and Marbu ...

DESCRIPTION provided by applicant Monitoring the HIV epidemic to understand rates and patterns of growth as well as targeting intervention efforts to populations exhibiting high rates f HIV transmission are wholly dependent on determining the frequency of new infections using an assay that discriminates recent from long term HIV infection However very few HIV assays have been developed spec ...

DESCRIPTION provided by applicant Electrochemical Home Monitoring System for Lithium Blood Level Over the past years pharmaceutical lithium has been one of the most widely used and prescribed drugs for the effective treatment of bipolar disorder and other manic disorders Despite the long history of use and efficacy controlling patient blood levels in the narrow therapeutic range ...

DESCRIPTION provided by applicant Mental health disorders exact very high personal social and economic costs in our country and around the world presenting a significant public health challenge Clinicians and researchers are currently faced with the difficult task of inferrig patient behavior and treatment adherence between clinic visits through self report and historical behavior Cogitoan ...

DESCRIPTION provided by applicant Lyme disease is the most prevalent vector borne disease in the U S with about cases per year reported by CDC and a range now covering states Early diagnosis and treatment of Lyme disease is important to prevent the disease from progressing to a systemic infection characterized by chronic arthritis carditis or neurological disorders Where a patien ...